The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents

Buyukınan, Muammer; Özen, Samim; Kokkun, Serap; Saz, Eylem Ulaş

doi:10.1515/jpem-2011-0426

Cited by 50 publications

(53 citation statements)

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“…The low average BMI and the low proportion of overweight participants are comparable to other studies in Shanghai [26] , and are representative of the general urban female population of Shanghai. Since previous studies [27][28][29][30] mainly focused on the relationship between vitamin D insufficiency and insulin resistance in obese populations, the results of our study provide evidence that abnormal vitamin D status may play a role in the pathogenesis of diabetes in a population with relatively low BMI.…”

Section: Discussionsupporting

confidence: 52%

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Tao

Zeng

et al. 2013

Acta Pharmacol Sin

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Aim: To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population. Methods: This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and β-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), respectively. Results: Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca 2+ and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001). Conclusion: Serum vitamin D level is significantly and independently associated with insulin resistance and β-cell function in a healthy Chinese female population.

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Section: Discussionsupporting

confidence: 52%

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Tao

Zeng

et al. 2013

Acta Pharmacol Sin

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“…In recent years, the relationship between vitamin D and glucose metabolism has been widely analyzed, although the results have been conflicting (4,6,8,25,26). In this study, we observed that vitamin D status and HOMA SDS differed between obese subjects during prepuberty and puberty.…”

Section: Discussionmentioning

confidence: 59%

“…The fact that vitamin D deficiency is more frequent in adolescents than in prepubertal children (5,6) suggests that puberty may be involved in the deficiency. However, there are few data in the literature regarding the influence of puberty on the vitamin D status of obese children and adolescents; moreover, the possible correlation between vitamin D status and insulin resistance requires further clarification (6).…”

Section: Introductionmentioning

confidence: 99%

The influence of puberty on vitamin D status in obese children and the possible relation between vitamin D deficiency and insulin resistance

Medina

Gavela-Pérez

Domínguez-Garrido

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Background: Puberty can affect vitamin D levels. Objectives: The goal of this study was to analyze the relation between vitamin D deficiency and puberty in obese Spanish children, along with the possible interrelation between vitamin D status and degree of insulin resistance. Methods: A cross-sectional study was carried out, in which clinical and biochemical data were gathered from 120 obese and 50 normal weight children between January 2011 and January 2013. Results: Mean vitamin D levels were 19.5 and 31.6 ng/mL in obese pubertal and obese prepubertal children, respectively. About 75% of the obese pubertal subjects and 46% of the obese prepubertal subjects had vitamin D deficiency. Vitamin D levels were significantly lower in pubescent subjects compared with pre-pubescent subjects in summer, fall, and winter. There was no apparent relation between vitamin D levels and homeostasis model assessment index for insulin resistence (expressed in standard deviation score for sex and Tanner stage) in either puberty or pre-puberty. Conclusion: Puberty may be a risk factor for the vitamin D deficiency commonly found in the obese child population. This deficiency is not associated with higher insulin resistance in obese pubertal children compared with obese prepubertal children.

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“…Also the findings from studies that examined only obese or overweight (BMI > 95th or BMI > 85th percentile) subjects (31)(32)(33)(34) were similar and did not differ from those with non-obese subjects (35)(36)(37)(38). Neither socioeconomic status nor physical activity where examined had any effect on the above findings (23,24,26,37).…”

Section: Vitamin D Deficiency and Its Relation To Mets Or Its Componentsmentioning

confidence: 71%

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Challa

Makariou

Siomou

2015

Journal of Pediatric Endocrinology and Metabolism

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Among children and adolescents, metabolic syndrome (MetS) is more common than previously believed. Hence, any information on the relation between vitamin D insufficiency/deficiency and insulin resistance (IR) in this population with risk of developing MetS is of great importance. This review analyzes and evaluates the existing evidence from cross-sectional, observational, and retrospective studies concerning the effect of vitamin D insufficiency/deficiency on MetS as a whole or on its various components. Most data show that insufficient vitamin D status is associated with increased prevalence of MetS or its individual components, mainly blood pressure and IR, often independent of overall obesity or abdominal adiposity. The implications of these findings could be associated with increased risk for developing cardiovascular disease and type 2 diabetes mellitus in later life. The very few randomized control trials examining any possible beneficial effects of vitamin D supplementation are also included.

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The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents

Cited by 50 publications

References 0 publications

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

The influence of puberty on vitamin D status in obese children and the possible relation between vitamin D deficiency and insulin resistance

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

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