The relation of the portal blood to liver maintenance

Rous, Peyton; Larimore, Louise D.

doi:10.3181/00379727-17-38

Cited by 22 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This abrupt change in the path of the blood is well tolerated by the organism, as an abundant experience has shown (13); and in the course of the present work it has been observed to have no effect on the carotid pressure, lgeedless to say the necessary operation was performed with the least possible trauma and exposure of the viscera, only a short segment of the vein being dissected free for ligation. * The hepatic artery, in special, was not touched; and it was seen by direct inspection to continue to beat strongly.…”

Section: The Service Rendered By the Hepatic Arterysupporting

confidence: 56%

Studies of Tissue Maintenance

Gilding

1929

Journal of Experimental Medicine

View full text Add to dashboard Cite

The vascular readjustments in compensation for a greatly reduced blood bulk affect the service rendered by the blood to the gastrointestinal tract and liver far less than they do that to the skin and muscles. Into these latter tissues india ink is carried almost not at all, whereas it circulates in quantity through the capillaries of the bowel and liver. Evidently vaso-constriction is much less effective in these viscera. Nowhere in them does one find a patchy ischemia like that so wide-spread in the peripheral tissues. Blood service is maintained to the same extent everywhere throughout the liver even when one of its two sources (hepatic artery or portal vein) is obstructed, and the intrahepatic blood pressure brought very low. A pronounced patchy ischemia of the stomach and large bowel can be induced by intravenous injection into normal animals of sufficient epinephrin to cause the systemic blood pressure to mount to an abnormally high level. Pituitrin used in the same way has a greater effect; blood service to the organs mentioned may be completely abolished by means of it. In both instances, though, service to the small gut and liver is still excellently and evenly maintained.

show abstract

Section: The Service Rendered By the Hepatic Arterysupporting

confidence: 56%

Studies of Tissue Maintenance

Gilding

1929

Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…In rabbits, it has been demonstrated that ligation of one branch of the portal vein leads to atrophy of the ischemic portion and hypertrophy of the vascularized region of the liver [11]. In human livers obtained at explant, segmental resection, or autopsy, it has been shown that apoptosis, focal atrophy, and nodular hyperplasia of the liver are associated with acute and healed portal vein thrombosis [12].…”

Section: Pathogenesismentioning

confidence: 99%

Nodular regenerative hyperplasia of the liver: An under‐recognized cause of portal hypertension in hematological disorders

2004

View full text Add to dashboard Cite

Portal hypertension has been described in a wide variety of hematological disorders, especially myeloproliferative and lymphoproliferative disorders. Its clinical manifestations may include bleeding esophageal varices, ascites, or hepatic encephalopathy. In patients with hematological disorders, there are a number of potential causes of portal hypertension, including nodular regenerative hyperplasia of the liver (NRH). This lesion is characterized by diffuse replacement of normal hepatic parenchyma by multiple small nodules composed of regenerating hepatocytes with minimal or no fibrosis. This lack of fibrosis distinguishes NRH from cirrhosis. Unlike cirrhosis, NRH only rarely results in compromised hepatic synthetic function. The major manifestation is portal hypertension related to increased resistance to blood flow within hepatic sinusoids. NRH has been linked to a variety of systemic diseases including collagen vascular diseases, myeloproliferative and lymphoproliferative disorders, as well as various medications. Although NRH is commonly associated with blood dyscrasias, the diagnosis is overlooked because of the complexity and wide differential diagnosis of liver diseases in the setting of hematological malignancy. We review herein nodular regenerative hyperplasia of the liver, including aspects of epidemiology, pathogenesis, differential diagnosis, clinical course, and treatment. We highlight its association with different forms of hematological disease, aiming to increase the awareness of this entity to the internist and the treating hematologist/oncologist. Am. J. Hematol. 75:225–230, 2004. © 2004 Wiley‐Liss, Inc.

show abstract

“…As there pointed out, the parenchymal cells of the liver compete with one another for existence (12); and the lobular capillaries converge and progressively unite on the way to the venous center, the result being that the further a ceU is from the blood source the greater is the quantity of blood passing it. Thus opportunity is equalized.…”

Section: The Gradient In the Mammalian Diaphragmmentioning

confidence: 99%

The Gradient of Vascular Permeability

Smith

Rous

1931

Journal of Experimental Medicine

View full text Add to dashboard Cite

A mounting gradient of permeability exists along the capillaries of frog muscle. In chicken muscle on the other hand none has been demonstrated; but the close-knit vascularization is arranged in duplicate in such manner that the blood runs in opposite directions through the capillaries of nearly adjacent fibres. In a flight muscle of the pigeon there exists in addition to this artifice what appears to be a special collecting system of venous capillaries. In the mammalian diaphragm indications of such a system are also to be found, and a gradient of capillary permeability like that in the other skeletal muscles is probably present. These vascular conditions are briefly considered in terms of function.

show abstract

The relation of the portal blood to liver maintenance

Abstract: The relation of the portal blood to liver maintenance.

Cited by 22 publications

References 0 publications

Studies of Tissue Maintenance

Studies of Tissue Maintenance

Nodular regenerative hyperplasia of the liver: An under‐recognized cause of portal hypertension in hematological disorders

The Gradient of Vascular Permeability

Contact Info

Product

Resources

About