The Relation of Tannic Acid to the Liver Necrosis Occurring in Burns

Wells, Donald B.; Humphrey, Henry D.; Coll, James J.

doi:10.1056/nejm194204162261601

Cited by 64 publications

(8 citation statements)

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“…Scientific references report evident correlation between dietary polyphenols rich diets and health enhancing properties: antioxidant properties [11][12][13], antibacterial activity on different bacterial strains in vitro and in vivo [7,[14][15][16][17][18][19][20], antiparasitic [21], antiulcerogenic [22][23][24] antidiarrhoic [25], antimutagenic [26][27][28][29][30][31][32][33], antitumor [34][35][36][37][38], and some neoplastic cell line apoptosis [39,40]. On the other hand, high tannins diets might also result in detrimental effects like hepatotoxicity [41,42], toxic nephrosis [43], oesphageal cancer [44], depression of feed intake and growth rate in many animal species [45][46][47][48][49][50][51].…”

Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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Proline contents of parotid glands (PG) in pigs constantly increase after the inclusion of different amounts of ripe hulled acorns in the diet providing high polyphenols levels. The dose-response relationship was estimated on natural hydrolizable tannins (expressed as tannic acid equivalent TAE) amounts of 25.8 to 36.1 g TAE/kg DM in experimental diets. Macroscopic and histological morphometry of parotid glands greatly varied according to feed intake and dosages of TAE ingested. The PG response (hypertrophy grade) on acorns' tannins content in the diet was positively correlated (R 2 = 0.748): the response to the protein precipitating activity (PPA) of tannins consisted of a functional parotidomegaly (hypertrophy), 1.34 up to 3.55 folds than control PGs, following an oral dosage 0.596 up 1.72 TAE g·kg -1 body weight·d -1 respectively, after one week exposure.

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Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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“…1938 b;Wolff et al, 1940;Thompson and Wilkinson, 1940;and Abbott and Holden, 1942], and also of histological liver damage [Bardeen, 1897;Pfeiffer, 1905;Olbrycht, 1924;and more recently Wilson et al, 1938;McClure, 1939;Belt, 1939;Brins and Hartmann, 1941;and Wells et al, 1942]. It was thought that changes in liver metabolism might prove a more sensitive test for liver damage than the microscopic appearance.…”

mentioning

confidence: 99%

“…It was thought that changes in liver metabolism might prove a more sensitive test for liver damage than the microscopic appearance. But it must be remembered that the histological damage and impaired liver function may be produced by tannic acid used in treatment [Wells et al, 1942;Cameron et al, 1943;Barnes and Rossiter, 1943;Clark and Rossiter, 1943;Erb et al, 1943;Robinson and Graessle, 1943;and Forbes and Evans, 1943]. Aneesthetics, too, may affect liver function tests [Boyce and McFetridge, 1938 a, and Thompson and Wilkinson, 1940] For experiments in phosphate buffer, 20 ml.…”

mentioning

confidence: 99%

Metabolism of Liver Slices After Burning

Clark¹,

Rossiter²

1944

Exp Physiol

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1. Anæsthetised rabbits burnt at 70°C. for ½ minute (area of burn ⅓ body surface) show a rise in red blood cell count within 2‐4 hours, which has fallen to normal by 24 hours. 2. There is no change in the ability of the liver to oxidise alanine or sodium butyrate either 4 or 24 hours after burning; there is also no change in the QGO2 and Qo2 measured in bicarbonate buffer. 3. After 4 hours there is a fall in the R. Q. (measured in phosphate buffer), rise in the QGN2, and fall in the ability of the liver to form glycogen from glucose; these have all returned to normal within 24 hours. 4. After 24 hours there is a slight rise in the Qo2 measured in phosphate buffer, which is not observed after 4 hours. 5. Implications of these results are discussed and it is concluded that they are in all probability secondary to the circulatory changes following the burn. Thanks are due to Dr. J. M. Barnes for advice and information on the method of burning the animals, and to Miss J. Jenkins for valuable technical assistance. One of us (E. J. C.) is indebted to the Medical Research Council for a personal grant and one (R. J. R.) to the Carnegie Trustees. The Medical Research Council has also contributed to the cost of this Research, which was carried out on behalf of the Burns Sub‐committee of the War Wounds Committee.

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“…Cephalin flocculation, and thymol turbidity were increased at first, but the thymol turbidity was not abnormal after the tenth post-burn day. In this instance repeated determination of the serum bilirubin was normal, and the urine urobilinogen excretion did not become abnormal at any time, but the urinary coproporphyrin 6 In three patients (Table I) who had greater than 10 per cent third degree burn, but less than 20 per cent burn, all showed B.S.P. retention, but in one of them it was only 7.9 per cent.…”

Section: Resultsmentioning

confidence: 60%