The relation of systemic lupus erythematosus activity and histopathology of renal biopsy

Abstract

Purpose: Detection of the relationship between the activity of SLE and the histopathology of renal biopsy. Patients and methods: This is a cross-sectional study. It included one hundred Egyptian patients with SLE according to the 2015 ACR/SLICC Revised criteria. SLE Disease Activity Index (SLEDAI) and renal biopsy were done on all patients in addition to the routine investigations.Results: Of the one hundred patients; Nine are males and 91 are females with a mean age ± standard deviation of 32.28 ± 9.59 years. The mean value of SLEDAI was 11.92 ± 3.92. Lupus nephritis (LN) was found in 85 patients (85%) included 5 patients (5%) having class 1, 73 patients (73%) having class 2, and 7 patients (7%) having class3 LN. SLEDAI mean value is directly proportional to the class of LN increasing from 10.6 ± 3.91 in normal cases to 16 ± 3.92 in class III LN. Conclusion:The relationship between the SLEDAI score and the histopathological study of renal biopsy in patients with SLE is strong and significant with a mean value of SLEDAI directly proportional to the class of LN.