The relation of susceptibility to and biologic behavior of thyroid epithelial cell cancer to HLA-DR1

Abstract

Fifty-two patients with thyroid epithelial cell cancer were studied for evidence of association with human leukocyte antigens (HLA). Twenty-eight patients (53.8%) and 19.4% of 160 controls were HLA-DRI-positive, conferring a relative risk of 4.85 (x2 = 21.3, P < 0.0001). HLA-DRl was increased in all histologic types of thyroid cancer. Interestingly 10 of 12 patients with metastatic disease were DR1-positive compared to 18 of 41 patients without metastases (relative risk = 6.1, xz = 4.7, P < 0.05). This study suggests that major histocompatibility complex-linked gene@) determine susceptibility to and the biologic behavior of thyroid cancer. Cancer 58:52-54, 1986. ECENT EVIDENCE suggests that the course of epithelial

Associations between HLA-C alleles and papillary thyroid carcinoma

“…HLA antigens have been associated with well differentiated thyroid carcinoma [7,9,11,13,16]. However no associations were found in some earlier studies [12,14,15].…”

“…The association of thyroid carcinoma with HLA alleles has been studied by several investigators [7][8][9][10][11][12][13][14][15][16][17]. HLA antigens have been associated with well differentiated thyroid carcinoma [7,9,11,13,16].…”

HLA-DR Association in Papillary Thyroid Carcinoma

“…Several reports support the association between different alleles of HLA and thyroid carcinoma in different populations [7][8][9][10][11][12][13][14][15][16][17]. However different results have also been reported [12,14,15].…”

“…However different results have also been reported [12,14,15]. Most studies on HLA Class II molecules antigens, have shown association with well differentiated thyroid carcinoma [7,9,11,13,16].…”

Towards Understanding the Molecular Basis of Thyroid Cancer

“…[87][88][89]80 In the absence of iodide deficiency, other HLA-linked influences were important for those exposed to other environmental hazards. At least in iodide deficient areas, HLA DR3 appeared to be permissive for nonmalignant transformation.…”