The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States)

Dorgan, Joanne F.; Reichman, Marsha E.; Judd, Joseph T.; Brown, Charles; Longcope, Christopher; Schatzkin, Arthur; Campbell, William H.; Franz, Charlene; Kahle, Lisa; Taylor, Philip R.

doi:10.1007/bf01830726

Cited by 98 publications

(60 citation statements)

References 48 publications

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“…In addition, results from experimental and cross-sectional data suggest that acute and chronic alcohol consumption increase endogenous oestrogen levels of both premenopausal and postmenopausal women (Mendelson et al, 1981(Mendelson et al, , 1987(Mendelson et al, , 1989; Teoh et al, 1988; Katsouyanni et al, 1991;Gavaler et al, 1993;Reichman et al, 1993;Dorgan et al, 1994;Hankinson et al, 1995). Overall, this evidence combined with results of a prospective study of endogenous oestrogens and postmenopausal breast cancer indicate that the effect of alcohol on breast cancer risk may be mediated by oestrogen.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

et al. 1999

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We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged ≤ 40 years and first diagnosed from 1 July 1983 to 1 January 1989. Eligible postmenopausal patients were 1169 women aged 55–64 years and first diagnosed from 1 March 1987 to 31 December 89. Patients were identified by the University of Southern California Cancer Surveillance Program. Neighbourhood controls were individually matched to patients by parity (premenopausal patients) and birth date (± 3 years). ER and PR status were obtained from medical records for 424 premenopausal and 760 postmenopausal patients. The analyses included 714 premenopausal and 1091 postmenopausal control subjects. Alcohol use was generally not associated with premenopausal risk of breast cancer, regardless of hormone-receptor status. Among the postmenopausal women, those who consumed, on average, ≥ 27 g of alcohol/d experienced an odds ratio (OR) of 1.76 [95% confidence interval (CI) 1.14–2.71] for ER-positive/PR-positive breast cancer relative to women who reported no alcohol consumption. Alcohol use was less clearly associated with risk of other receptor types among postmenopausal women. These data suggest that alcohol may preferentially increase risk of ER-positive/PR-positive breast cancer in postmenopausal women. © 1999 Cancer Research Campaign

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Section: Discussionmentioning

confidence: 99%

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

et al. 1999

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“…Several studies have shown associations between alcohol intake and high levels of plasma or urinary E 2 (Katsouyami et al, 1991;Reichman et al, 1993;Hankinson et al, 1995), estrone, androstenedione, IGF-I and prolactin (Soyka et al, 1991;Singletary and Gapstur, 2001), as well as lower levels of FSH (Singletary and Gapstur, 2001), while others have shown no such associations (Cauley et al, 1989;London et al, 1991;Dorgan et al, 1994;Newcomb et al, 1995).…”

Section: Risk Factors For Uterine Leiomyomata In Black Womenmentioning

confidence: 99%

“…Smoking is associated with lower serum and urinary estrogen levels in some (MacMahon et al, 1982; Westhoff et al, 1996), but not all (Longcope and Johnston, 1988;Zumoff et al, 1990;Daniel et al, 1992), studies. Alcohol consumption is associated with higher endogenous levels of estradiol (E 2 ) and estrone (Katsouyami et al, 1991;Reichman et al, 1993;Hankinson et al, 1995), but other studies show no such associations (Cauley et al, 1989;London et al, 1991;Dorgan et al, 1994;Newcomb et al, 1995). Coffee and caffeine consumption are associated with increased levels of early follicular phase E 2 , independent of alcohol or tobacco use (Lucero et al, 2001), and may enhance sex steroid production (Leonard et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Wise

Palmer

Harlow³

et al. 2004

Human Reproduction

116

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BACKGROUND: Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism. METHODS: We prospectively assessed the relation of these exposures to risk of self-reported uterine leiomyomata in the Black Women's Health Study. From 1997 to 2001, we followed 21 885 premenopausal women with intact uteri and no prior myoma diagnosis. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs). RESULTS: During 73 426 person-years of follow-up, 2177 incident cases of uterine leiomyomata confirmed by ultrasound (n 5 1920) or hysterectomy (n 5 257) were reported. Cigarette smoking was not associated with risk of uterine leiomyomata. Risk was positively associated with years of alcohol consumption and current consumption of alcohol, particularly beer. Relative to non-drinkers, multivariate IRRs for beer consumption of <1, 1 -6 and 71 drinks/week were 1.11 (95% CI 0.98-1.27), 1.18 (95% CI 1.00-1.40) and 1.57 (95% CI 1.17-2.11), respectively. Heavy coffee and caffeine consumption were not associated with risk overall, but IRRs were increased among women aged <35 years. CON-CLUSIONS: In US black women, risk of uterine leiomyomata was positively associated with current consumption of alcohol, particularly beer. Cigarette smoking and caffeine consumption were unrelated to risk overall.

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“…Disruption of sex steroid homeostasis, including a reduction in serum estradiol, is also a reported feature of young female alcoholics (Dorgan et al, 1994). Sex steroids have been reported to protect against bone loss, and it is possible that impaired sex steroid signaling contributes to EtOHinduced bone loss (Turner and Sibonga, 2001).…”

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confidence: 99%

Estradiol Protects against Ethanol-Induced Bone Loss by Inhibiting Up-Regulation of Receptor Activator of Nuclear Factor-κB Ligand in Osteoblasts

Chen

Haley

Hidestrand

et al. 2006

J Pharmacol Exp Ther

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To investigate the effects of sex hormones on ethanol (EtOH)-induced bone loss, female Sprague-Dawley rats were fed control or EtOH-containing diets (12 g/kg/day) by intragastric infusion. After 3 weeks, rats receiving EtOH had significant decreases in tibial trabecular and total bone mineral density, induction of receptor activator of nuclear factor-〉 ligand (RANKL) mRNA expression, and enhanced bone resorption, all of which were prevented by treatment with 17␤-estradiol (E 2 ). The addition of progesterone did not enhance the beneficial effect of E 2 alone. Consistent with our in vivo findings, EtOH stimulated RANKL mRNA expression in cultured primary osteoblasts, and this expression was blocked by 4-methylpyrazole. Acetaldehyde also induced RANKL expression. Class 1 alcohol dehydrogenase was found to be expressed and EtOHinducible in cultured osteoblasts, whereas CYP2E1 was undetectable. We found that EtOH induced phosphorylation of extracellular signal-regulated kinase (ERK) and signal transducers and activators of transcription 3 (STAT3). E 2 and the mitogenactivated protein kinase kinase inhibitor 2Ј-amino-3Ј-methoxyflavone (PD98059) blocked ERK and STAT3 phosphorylation and blocked RANKL induction. Moreover, E 2 completely blocked EtOH-induced osteoclastogenesis in a primary osteoblast and osteoclast precursor coculture system. The E 2 effects were estrogen receptor-mediated. Therefore, E 2 prevents EtOH-induced bone loss by opposing the induction of RANKL mRNA in osteoblasts and ethanol-induced osteoclastogenesis, through opposing effects on sustained ERK signaling.

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The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States)

Cited by 98 publications

References 48 publications

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Estradiol Protects against Ethanol-Induced Bone Loss by Inhibiting Up-Regulation of Receptor Activator of Nuclear Factor-κB Ligand in Osteoblasts

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