The relation of postsynaptic geometry to the number of presynaptic axons that innervate autonomic ganglion cells

Purves, Dale; Hume, Richard I.

doi:10.1523/jneurosci.01-05-00441.1981

Cited by 157 publications

(83 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many neurones possessed several primary dendrites that ramified throughout the ganglion. As in other autonomic ganglia, there was a marked tendency for the cells with the most extensive dendrites to receive detectable input from the largest number of preganglionic axons (Purves & Hume, 1981;Purves & Lichtman, 1985).…”

Section: Resultsmentioning

confidence: 79%

Innervation of the iris by individual parasympathetic axons in the adult mouse.

Jackson¹

1986

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Ciliary neurones were identified electrophysiologically in isolated ganglia and the projection of individual axons to the intrinsic muscles of the eye determined by labelling identified cells with horseradish peroxidase (HRP).2. The ciliary ganglion of the adult mouse contains 80-100 parasympathetic neurones clustered at the point where the oculomotor nerve branches to supply the medial and inferior rectus. 3. These nerve cells show varying degrees of dendritic complexity (zero to six primary dendrites) and differing degrees of innervation by preganglionic axons (one to seven inputs). Cells with more complex dendritic arborization generally receive synaptic input from commensurately larger numbers of preganglionic axons.4. The axons of individually labelled cells give rise to varicose terminals in the iris and ciliary body; in most cases a single parent axon branches only after entering the iris, producing a network of terminals in the region of both the sphincter and the antagonist dilator muscle. Cells with both simple and complex dendritic geometry show this pattern of axonal arborization.5. The usual net effect of stimulating a single ciliary ganglion neurone through an intracellular electrode is constriction of the pupil. Since the terminals of individual ciliary ganglion neurones are commonly distributed to both the sphincter and dilator regions of the iris, impulses invading the terminals of a single ciliary neurone cause a contraction of the sphincter muscle, perhaps accompanied by a simultaneous relaxation of the dilator.6. Direct examination of individually labelled neurones has revealed details of the pattern of parasympathetic axon distribution to the iris, thus accounting for the origin of cholinergic terminals in the dilator, classically considered to be primarily a target of adrenergic sympathetic neurones.

show abstract

Section: Resultsmentioning

confidence: 79%

Innervation of the iris by individual parasympathetic axons in the adult mouse.

Jackson¹

1986

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Although the functional differences in the variable size of neuronal soma is not well understood, it was reported that neurons with larger soma and more extensive dendritic arborization receive a greater number of neuronal inputs than those with smaller soma and poor dendritic arborization [40,41]. Furthermore, the number of presynaptic axons innervating each sympathetic neuron is proportional to the number of primary dendrites [39]. It was reported that axotomy of sympathetic neurons causes significant dendritic atrophy [57].…”

Section: Discussionmentioning

confidence: 99%

Differences in Morphology and Neuropeptide Immunoreactivity of Superior Cervical Ganglion Neurons that Innervate the Major Salivary Glands in Rats.

Miyauchi

Asamoto

Nojyo

et al. 2001

Acta Histochem. Cytochem

View full text Add to dashboard Cite

A neuronal tracer, WGA-HRP, was injected into the rat parotid gland (PG), submandibular gland (SMG), and sublingual gland (SLG) to label the superior cervical ganglion (SCG) neurons, and the number, size of soma, dendritic arborization and immunoreactivities (IR) of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were investigated. The number and size of neurons projecting into SMG were greater than those of neurons projecting into the PG or SLG. The PG and SLG projecting neurons did not show significant differences in their number and size of soma, even the weight of the SLG was much smaller than the other two glands. The total length of dendrites of the SMG projecting neurons was greater than those of the PG or SLG projecting neurons. PG and SLG projecting neurons showed no significant difference in the total length of their dendrites. PG and SLG projecting neurons with NPY-IR were larger in number than SMG projecting neurons. SLG projecting neurons with VIP-IR were greater in number than neurons projecting into the other two glands. Our results indicate the differences in morphology and neuropeptide immunoreactivities among the SCG neurons which may be due to the differences in the neuronal functions and the participation of neurotrophic factors.

show abstract

“…Only about 8% of frog intracardiac neurons receive more than two presynaptic inputs [2]. From previous studies on mammalian heart it is also known that neurons without dendrites are frequently innervated by a single axon, while those with dendrites are innervated by multiple axons proportionally to the structural complexity of dendrites [12]. Th us, fi nding more dendrite-like processes on the somata of non-ganglionic neurons may indicate the possibility that these neurons receive more synaptic inputs compared to ganglionic neurons.…”

Section: Discussionmentioning

confidence: 99%

“…Autonomic neurons that receive only one presynaptic input usually have no primary dendrites. Th e number of primary dendrites increases with the number of presynaptic inputs [12,13]. According to earlier studies, cranial and terminal autonomic ganglia of small vertebrates like the frog, the mouse or the hamster contain mostly non-dendritic neurons that are innervated by 1-2 preganglionic axons [2,13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ganglionic and non-ganglionic neurons in frog heart: do they differ?

Batulevičius

Skripkienė

Graužinytė

et al. 2017

PoA

View full text Add to dashboard Cite

This study was designed to compare the morphology of neurons in relation to their distance from the major nerve trunks in the heart of the frog Rana temporaria. Seventy-nine intracardiac neurons were labelled intracellularly with fluorescent markers Lucifer Yellow CH and Alexa Fluor 568. The neurons located on the extensions of the vagus nerve were considered as ganglionic, while neurons spread loosely at further distance from these extensions were considered as non-ganglionic. The mean area of the soma in ganglionic neurons was about 25% larger than in non-ganglionic neurons. Ganglionic neurons had a higher soma area/nucleus area ratio than non-ganglionic neurons. Although both the total number and the total length of dendrite-like processes was similar between the two groups, ganglionic neurons had significantly fewer dendrite-like processes from the soma (1.5±0.3 vs. 3.9±1.0; P<0.05) and shorter total length of these processes from the soma (63±18 μm vs. 178±51 μm; P<0.05). In conclusion, ganglionic and non-ganglionic frog intracardiac neurons exhibit substantial morphological differences. We hypothesize that these differences may indicate different projections or variations in the number of their preganglionic inputs.

show abstract

The relation of postsynaptic geometry to the number of presynaptic axons that innervate autonomic ganglion cells

Cited by 157 publications

References 12 publications

Innervation of the iris by individual parasympathetic axons in the adult mouse.

Innervation of the iris by individual parasympathetic axons in the adult mouse.

Differences in Morphology and Neuropeptide Immunoreactivity of Superior Cervical Ganglion Neurons that Innervate the Major Salivary Glands in Rats.

Ganglionic and non-ganglionic neurons in frog heart: do they differ?

Contact Info

Product

Resources

About