The relation of passive smoking with cervical cancer

Su, Benyu; Qin, Wen; Xue, Feng; Wei, Xiaomin; Guan, Qiangdong; Jiang, Wenchong; Wang, Shue; Xu, Mengmeng; Sung, Yunsick

doi:10.1097/md.0000000000013061

Cited by 51 publications

(52 citation statements)

References 29 publications

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“…Tobacco smoking has been established as an important risk factor in cervical carcinogenesis [1, 18–21] and oral HPV infection [22, 23]. However, even though there are several reports on the effects of SHS [2–9, 24], the association between SHS and cervical carcinogenesis has never been clearly evaluated. Persistent infection with HR-HPV genotypes (13 oncogenic) is the first in the following series of steps leading to cervical cancer: HPV infection of metaplastic epithelium, viral persistence, progression to a cervical precancerous lesion, and invasion [10].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, SHS has been associated with the risk of cervical neoplasia in several Asian countries such as Taiwan, Singapore, and Thailand [4, 5, 7, 9]. A recent meta-analysis provided evidence that passive smoking is associated with an increased risk of cervical cancer [24]. However, a pooled study including couples in seven case-control studies reported that SHS was not an independent risk factor of invasive cervical cancer in the absence of active smoking.…”

Section: Discussionmentioning

confidence: 99%

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Combined Effect of Secondhand Smoking and Alcohol Drinking on Risk of Persistent Human Papillomavirus Infection

Seo

Kim

et al. 2019

BioMed Research International

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Tobacco smoking is established as a cofactor of human papillomavirus (HPV) for cervical cancer risk. However, the role of secondhand smoking in cervical carcinogenesis is controversial. We aimed to assess the association between secondhand smoking and high risk- (HR-) HPV persistence, a pivotal event in development of cervical cancer. In total, 9,846 women who underwent health-screening examinations from 2002 to 2011 at the National Cancer Center, Korea, were included. Secondhand smoking was defined as being exposed to secondhand smoke at home or in the workplace. Multivariate logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (CIs) for risks of HR-HPV infection at baseline (N, 9,846, negative vs. positive), 1-year persistence (n, 1,237, 1-year negative vs. 1-year persistence), and 2-year persistence (n, 481, 2-year negative vs. 2-year persistence). Active smoking, secondhand smoking, and secondhand smoking in nonactive smokers had no association with these risks. Among alcohol drinkers, secondhand smoking in nonactive smokers had higher risks of HR-HPV infection at baseline (OR = 1.25, 95% CI = 1.05–1.48, p for multiplicative interaction = 0.003), 1-year persistence (1.75, 1.14–2.68, 0.004), and 2-year persistence (2.96, 1.42–6.15, 0.006), when compared to HR-HPV negative, 1-year negative, and 2-year negative categories, respectively. However, among nonalcohol drinkers, there was no association between smoking or secondhand smoking status and these risks. These findings suggest that women exposed to secondhand smoking at home or in the workplace might be at high risk of HR-HPV persistence when it is combined with alcohol drinking, even though neither active smoking nor secondhand smoking independently affects the risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combined Effect of Secondhand Smoking and Alcohol Drinking on Risk of Persistent Human Papillomavirus Infection

Seo

Kim

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

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“…In a case-control study with 177 cervical cancer cases and 177 controls, females with sexual partners who were smokers showed an increased risk of developing cervical cancer (OR 2.77, p < 0.001, and adjusted OR 3.15, p = 0.001) [40]. In a meta-analysis of 14 eligible studies, which included a total of 384,995 participants, the pooled OR of passive smoking for the risk of cervical cancer was 1.70 [41].…”

Section: Smoking and Cervical Carcinogenesismentioning

confidence: 99%

The Preventive Effect of Dietary Antioxidants against Cervical Cancer versus the Promotive Effect of Tobacco Smoking

2019

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Uterine cervical cancer is the fourth most common cancer in women, and its etiology has been recognized. High-risk human papilloma virus (HR-HPV) infection induces an opportunity for malignant transformation. This paper discusses the current issues based on a review of the literature and compares the impact of the dietary and nutrient intake to the impact of tobacco smoking on cervical cancer development. The important roles of diet/nutrition in cervical cancer are as prophylaxis against HR-HPV infection. Antioxidant vitamins can inhibit the proliferation of cancer cells, stabilize the p53 protein, prevent DNA damage, and reduce immunosuppression. In contrast, tobacco smoking not only causes DNA adducts and strand breaks, but it independently causes an increased viral load in HR-HPV-infected cells. Tobacco smoking induces the heightened expression of E6 and E7 and can inhibit the immune system response to HPV. What happens when two materials, which have opposite effects on cervical cells, are taken in at the same time? The negative effects of tobacco smoking may be stronger than the positive effects of vitamins, vegetables, and fruits on the regression of cervical disease such as cervical intraepithelial neoplasia (CIN). A relatively low intake of vitamins, vegetables, and fruits in combination with tobacco smoking was most associated with a high incidence of cervical neoplasia.

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“…Cervical cancer is one of the most prevalent malignant neoplasms and causes of cancer-related deaths worldwide [ 1 ]. It was reported that high-risk human papillomavirus (HR-HPV) infection [ 2 , 3 , 4 ] and tobacco exposure [ 3 , 5 , 6 ] are the predominant risk factors leading to cervical cancer. However, host immune responses play important roles in protecting against the development of cervical cancer [ 7 , 8 ] and strategies which protect women from cervical cancer risk are strongly needed.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity of ≥7.5 MET-h/Week Is Significantly Associated with a Decreased Risk of Cervical Neoplasia

et al. 2020

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Cervical cancer is one of the most prevalent malignant neoplasms worldwide. We investigated whether leisure-time physical activity is sufficient to decrease the cervical neoplasia risk and provide suggested guidance of metabolic equivalents of task–hours per week (MET-h/week) spent on leisure-time physical activity to prevent cervical neoplasia. Ultimately, 433 participants, including 126 participants with cervical intraepithelial neoplasia I or higher disease (≥CIN 1) and 307 healthy controls, were recruited. All participants completed a standardized questionnaire about leisure-time physical activity engagement (MET-h/week) and a general health questionnaire and had cervical specimens taken to detect human papillomavirus (HPV) infection. CIN 1 staging was identified from the specimens. Participants with physical activity of ≥3.75 MET-h/week had a significantly lower CIN risk compared to those with physical activity of <3.75 MET-h/week (p = 0.01). However, among participants with HPV infection or smokers, the minimal requirement of leisure-time physical actively to lessen the CIN risk was ≥7.5 MET-h/week. Lifetime leisure-time physical activity of ≥0.12 MET-h/week–year also significantly decreased the CIN risk, but women with HPV infection needed ≥13.2 MET-h/week–year to protect them from a CIN risk. We concluded that regular leisure-time physical activity of ≥7.5 MET-h/week and sustained lifetime leisure-time physical activity ≥13.2 MET-h/week–year are vital factors for protecting women against cervical neoplasia risk.

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The relation of passive smoking with cervical cancer

Cited by 51 publications

References 29 publications

Combined Effect of Secondhand Smoking and Alcohol Drinking on Risk of Persistent Human Papillomavirus Infection

Combined Effect of Secondhand Smoking and Alcohol Drinking on Risk of Persistent Human Papillomavirus Infection

The Preventive Effect of Dietary Antioxidants against Cervical Cancer versus the Promotive Effect of Tobacco Smoking

Physical Activity of ≥7.5 MET-h/Week Is Significantly Associated with a Decreased Risk of Cervical Neoplasia

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