The Relation of Lymphomaand Hepatitis B Virus/Hepatitis C Virus Infections in the Region of East Black Sea, Turkey

Sönmez, Mehmet; Bektas, Ozlen; Yılmaz, Mustafa; Durmuş, Ahmet; Akdoğan, Elif; Topbaş, Murat; Ertürk, Murat; Ovalı, Ercüment; Omay, Serdar Bedii

doi:10.1177/030089160709300603

Cited by 19 publications

(15 citation statements)

References 34 publications

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“…These three DNA viruses have already shown to play an important role in the pathogenesis of different cancers through their interference with cellular DNA repair mechanisms [5][6][7]. We found that the prevalence of HBV, HSV1 and EBV was significantly higher in those who were diagnosed to have ALL.…”

Section: Discussionmentioning

confidence: 60%

“…Defective or inhibited repair of DNA breaks will results in translocations (the hallmark genetic mutations of ALL) and this is a key step in pathogenesis of ALL. Previous studies have shown that some DNA viruses' infection, notably herpes viruses, Epstein-Barr virus (EBV) and Hepatitis B virus (HBV) interferes with cellular DNA repair mechanisms [5][6][7] and could lead to these characteristic genetic changes. Previous studies tried to determine the association between prenatal virus infections and development of pre-leukemic cells containing characteristic translocations; however they showed no association between infection with polyoma viruses [8], herpesviruses [9,10], or parvovirus B19 [11] and childhood ALL.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Human Herpes Simplex, Hepatitis B and Epstein-Barr Viruses in Children with Acute Lymphoblastic Leukemia in Southern Iran

Mahjour

Ghaffarpasand

Fattahi

et al. 2010

Pathol. Oncol. Res.

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To investigate the seroprevalence of Herpes Simplex Viruses (HSV1 and HSV2), Ebstein-Barr Virus (EBV) and Hepatitis B Virus (HBV) in children with acute lymphoblastic leukemia (ALL) in southern Iran. 90 patients with ALL and 90 age-sex matched healthy participants were enrolled in this study. Antibodies (IgG) against HBsAg, HSV1, HSV2, EBV different antigens including Epstein-Barr nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA) and early antigen (EA) were measured by enzyme-linked immunosorbent assay (ELISA). There were 54 (60%) male and 36 (40%) female in both study groups with mean age of 8.47 ± 3.61 and 8.61 ± 2.84 years in case and control group respectively (P = 0.812). The prevalence of antibodies against HBsAg (P = 0.002), HSV1 (P < 0.0001), VCA (P = 0.021) and EA (P < 0.0001) antigens of EBV were significantly higher in ALL patients. With the results of this study, we could not exclude a connection between these viral infections and later leukemogenesis in childhood ALL, although nor latent infection nor congenital infection cannot be excluded by this method.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Human Herpes Simplex, Hepatitis B and Epstein-Barr Viruses in Children with Acute Lymphoblastic Leukemia in Southern Iran

Mahjour

Ghaffarpasand

Fattahi

et al. 2010

Pathol. Oncol. Res.

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“…Several studies have reported a significant association between chronic HBV infection and non-Hodgkin's lymphoma (NHL), mainly in HBV endemic areas, [1][2][3][4][5] while some controversial results on the association in different geographic areas have been reported. 6,7 The clinical course and outcome of chronic HBV infection is determined by the interplay between virus replication and the host immune response. 8 Immunosuppressive therapy, including anticancer systemic chemotherapy, can induce HBV replication and reactivation of hepatitis B, which may lead to hepatitis flare and even hepatic failure, in hematologic malignancy, such as NHL and leukemia, as well as solid cancers.…”

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis B, non-Hodgkin's lymphoma, and effect of prophylactic antiviral therapy

Kim

Jeong

Kim

et al. 2011

Journal of Clinical Virology

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“…However, Isikdogan et al [13] found no association in 119 NHL patients. Similarly, Timuraglu et al [14] and Sonmez et al [15] identified no association. Summarizing the results from across Turkey, all that can be stated is that the evidence in inconclusive (Tables 5, 6).…”

Section: Discussionmentioning

confidence: 91%

Prevalence of hepatitis B and C viruses in patients with lymphoproliferative disorders

et al. 2008

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The etiology of most lymphoproliferative disorders remains unclear, though several hypotheses have been proposed. One of the conjectured mechanisms is infection of a tumor clone by an oncologic virus. Recently, evidence has arisen implicating both hepatitis B and, even more so, hepatitis C viruses in the pathogenesis of lymphoproliferative disease. Based on this information, we surveyed the prevalence of hepatitis B and C virus in patients with lymphoproliferative disease. A total of 334 newly-diagnosed lymphoproliferative disease patients (200 males, 134 females) and 1,014 (133 females, 881 males) healthy controls were randomly recruited from the university blood bank. Serologic evaluation for hepatitis B and C viruses was conducted and confirmed using PCR analyses. Those with hepatitis B and/or C, controls, and subgroups of patients with lymphoproliferative disease were compared using Pearson Chi-square analysis. Among patients with lymphoid tumors, the seropositivity of HbsAg and/or anti-HCV was 8.7% (29/334), and among the controls 6.1% (49/802), however this difference did not achieve statistical significance (P = 0.23, OR: 1.36, 95% CI: 0.82-2.26). We found no significant gender- or age-related differences for either hepatitis B or C seropositivity. There were no significant differences between the seropositivity rates of hepatitis B, C, or both in either NHL or Hodgkin's lymphoma. However, in the diffuse large cell lymphoma and follicular lymphoma subgroups, the HbsAg seropositivity rate was significantly higher than that in the controls (P = 0.017, P = 0.048, respectively), as was the seropositivity rate for hepatitis C in those with diffuse B cell lymphoma versus controls (P = 0.008). We did not identify any significant difference in the combined prevalence of hepatitis B or C seropositivity between patients with lymphoproliferative disorders and controls. However, significant differences were revealed among certain patient subgroups versus the controls. These two viruses could play a role in the development of certain specific lymphoproliferative disorders. Nevertheless, larger epidemiological studies are necessary and should focus, particularly on specific patient subgroups.

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The Relation of Lymphomaand Hepatitis B Virus/Hepatitis C Virus Infections in the Region of East Black Sea, Turkey

Abstract: Our findings suggest that the incidence of HBV and HCV infections in lymphoma patients is no different than that of nonlymphoma patients. Therefore, no direct correlation can be deduced between lymphoma and HBV-HCV infections in our East Black Sea region of Turkey.

Cited by 19 publications

References 34 publications

Seroprevalence of Human Herpes Simplex, Hepatitis B and Epstein-Barr Viruses in Children with Acute Lymphoblastic Leukemia in Southern Iran

Seroprevalence of Human Herpes Simplex, Hepatitis B and Epstein-Barr Viruses in Children with Acute Lymphoblastic Leukemia in Southern Iran

Chronic hepatitis B, non-Hodgkin's lymphoma, and effect of prophylactic antiviral therapy

Prevalence of hepatitis B and C viruses in patients with lymphoproliferative disorders

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