The Relation of Erythropoietin Towards Hemoglobin and Hematocrit in Varying Degrees of Renal Insufficiency

Panjeta, Mirsad; Tahirovic, I; Karamehić, Jasenko; Sofić, E.; Riđić, Ognjen; Ćorić, Jozo

doi:10.5455/msm.2015.27.144-148

Cited by 23 publications

(16 citation statements)

References 22 publications

(26 reference statements)

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“…Additionally, it is known that EPO stimulates erythropoiesis, which leads to increased production of erythrocytes and, subsequently, an increase in haematocrit . Moreover, some trials have raised safety concerns about the drug and suggested that pro‐thrombotic effects may mitigate potential benefits.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effect of Erythropoietin in the TNBS‐induced Colitis

Mateus

Rocha

Alves

et al. 2016

Basic Clin Pharma Tox

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Erythropoietin is a potent stimulator of erythroid progenitor cells, which is able to inhibit NF-kB activation, due to its pleiotropic properties, thus promoting an anti-inflammatory effect. As inflammatory bowel disease is a chronic disease with reduced quality of life, and the current pharmacotherapy only induces or maintains the patient in remission, there is a crucial need of new pharmacological approaches. The main objective of this study was to evaluate the effect of erythropoietin in the TNBS-induced colitis model in mice with a normal intestinal flora. Mice with TNBS-induced colitis were treated with a daily dose of erythropoietin at 500 IU/kg bw/day and 1000 IU/Kg bw/day IP during 4 days. As to clinical symptoms/signs, erythropoietin attenuated the decreased body-weight and reduced diarrhoea and oedema of the anus registered in the non-treated mice group in a dose-dependent manner. The anti-inflammatory properties of erythropoietin in the TNBS-induced colitis were confirmed by suppression of pro-inflammatory mediators, such as TNF-α, IL-1β and MPO, as well as a significant increase in the anti-inflammatory cytokine, IL-10, was promoted. These treated mice also presented a reduction in haemoglobin faecal and ALP, suggesting a beneficial effect of erythropoietin in the haemorrhagic focus and destruction of the enterocyte associated with the colon injury induced by TNBS, respectively. The histopathological score was reduced after treatment with erythropoietin, decreasing the severity and extension of the colitis. Furthermore, renal and hepatic biomarkers, as well as haematocrit concentration, remained stabilized after treatment. In conclusion, erythropoietin reduces the inflammatory response associated with TNBS-induced colitis in mice.

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Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effect of Erythropoietin in the TNBS‐induced Colitis

Mateus

Rocha

Alves

et al. 2016

Basic Clin Pharma Tox

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“…In our study, there was higher prevalence of CKD among non-dippers and reversedippers compared with dippers. With the worsening kidney function we observed lower HGB concentration [31]. Non-dipping patients are described to have impairment in autonomic nervous drive (especially parasympathetic inactivity) [32].…”

Section: Discussionmentioning

confidence: 65%

Determinants of the circadian blood pressure pattern in hospitalized hypertensive patients

Zaleska¹,

Możeńska²,

Segiet³

et al. 2019

Arterial Hypertension

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Background. Non-dipping hypertension might be associated with increased cardiovascular risk and multiple diseases. The aim of our study was to assess if there are parameters identified in 24-hour ECG-Holter monitoring (ECG-Holter), transthoracic echocardiography (TTE), ECG parameters or laboratory data that allow prediction of circadian blood pressure profile (CBPP). Material and methods. One hundred and three consecutive patients (male: 50.5%), who underwent 24-hour ambulatory BP measurement and ECG-Holter simultaneously were analyzed. We divided patients into 3 groups: dipping was defined as 10-20% (28.2%), non-dipping as < 10% (50.5%) fall in nocturnal BP and reverse-dipping as higher nocturnal than diurnal BP (21.4%). Additionally, we performed TTE and laboratory check-up in all patients. We built multivariable models for nocturnal fall in systolic BP (SBP) and CBPP. Results. Multivariable model based on clinical factors was: nocturnal fall in SBP (%) = [13.28 -0.11 × age -8.33 × (dilated cardiomyopathy) -5.95 × PAD -6.02 × a-adrenolytic]. Multivariable model based on laboratory, echocardiographic and electrocardiographic parameters was: nocturnal fall in SBP (%) = [-27.28 + 1.47 × hemoglobin -0.14 × CK-MB + 0.14 × maximal heart rate]. Multivariable model for CBPP based on clinical factors included use of bor a-adrenolytics or torasemide.Conclusions. We proved that nocturnal fall in SBP and CBPP could be predicted based on ECG-Holter parameters, laboratory data and TTE results, as well as based on detailed medical history. These findings may have implications on care of patients with hypertension.

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“…We now demonstrate that capsaicin reduces hemoglobin when administered as part of a high-iron diet [ 5 ]. As previously mentioned, diabetes per se may modify hemoglobin concentration, mainly via renal dysfunction which alters erythropoietin synthesis, and subsequently hemoglobin level [ 5 , 6 ]. Our data show that the reduction in hemoglobin level achieved using both oral and subcutaneous capsaicin, were greater than that achieved by the diabetic state alone.…”

Section: Discussionmentioning

confidence: 99%

“…Mechanistically, the major iron-regulating hormone, hepcidin, is known to regulate intestinal iron absorption, and modulates erythropoiesis [ 4 ]. Also of relevance is the renal dysfunction that accompanies diabetes, which can also modify hemoglobin regulation [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Dietary Iron and Capsaicin on Hemoglobin, Blood Glucose, Insulin Tolerance, Cholesterol, and Triglycerides, in Healthy and Diabetic Wistar Rats

et al. 2016

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ObjectiveOur aim was to assess the effects of dietary iron, and the compound capsaicin, on hemoglobin as well as metabolic indicators including blood glucose, cholesterol, triglycerides, insulin, and glucose tolerance.Materials and MethodsOur animal model was the Wistar rat, fed a chow diet, with or without experimentally induced diabetes. Diabetic males were fed control, low, or high-iron diets, the latter, with or without capsaicin. Healthy rats were fed identical diets, but without the capsaicin supplement. We then measured the parameters listed above, using the Student t-test and ANOVA, to compare groups.ResultsHealthy rats fed a low-iron diet exhibited significantly reduced total cholesterol and triglyceride levels, compared with rats fed a control diet. Significantly reduced blood lipid was also provoked by low dietary iron in diabetic rats, compared with those fed a control diet. Insulin, and glucose tolerance was only improved in healthy rats fed the low-iron diet. Significant increases in total cholesterol were found in diabetic rats fed a high-iron diet, compared with healthy rats fed the same diet, although no statistical differences were found for triglycerides. Hemoglobin levels, which were not statistically different in diabetic versus healthy rats fed the high-iron diet, fell when capsaicin was added. Capsaicin also provoked a fall in the level of cholesterol and triglycerides in diabetic animals, versus diabetics fed with the high iron diet alone. In conclusion, low levels of dietary iron reduced levels of serum triglycerides, hemoglobin, and cholesterol, and significantly improved insulin, and glucose tolerance in healthy rats. In contrast, a high-iron diet increased cholesterol significantly, with no significant changes to triglyceride concentrations. The addition of capsaicin to the high-iron diet (for diabetic rats) further reduced levels of hemoglobin, cholesterol, and triglycerides. These results suggest that capsaicin, may be suitable for the treatment of elevated hemoglobin, in patients.

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The Relation of Erythropoietin Towards Hemoglobin and Hematocrit in Varying Degrees of Renal Insufficiency

Cited by 23 publications

References 22 publications

Anti‐Inflammatory Effect of Erythropoietin in the TNBS‐induced Colitis

Anti‐Inflammatory Effect of Erythropoietin in the TNBS‐induced Colitis

Determinants of the circadian blood pressure pattern in hospitalized hypertensive patients

The Effects of Dietary Iron and Capsaicin on Hemoglobin, Blood Glucose, Insulin Tolerance, Cholesterol, and Triglycerides, in Healthy and Diabetic Wistar Rats

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