The relation of diet with PAF and its metabolic enzymes in healthy volunteers

Abstract

In conclusion, the DAC and healthy dietary patterns were inversely associated with PAF or its biosynthetic enzymes, suggesting potential new mechanisms of the diet-disease associations.

Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages

“…These observations prompted us to address whether AKGs had any effect on macrophage PAF production. Although AKG metabolism is poorly understood, recent studies have outlined the possibility that AKGs are utilized by a multienzyme-catalyzed process to generate PAF (15,45), a potent phospholipid mediator (26,27,46) ( Figure 4B). In line with these predictions, we found that AKG treatment led to PAF release from mouse and human ATMs and that AKGs mirrored the transcriptional changes evoked by PAF in macrophages ( Figure 4, C and D, and Supplemental Figure 10, F-J).…”

Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis

“…In healthy volunteers healthy dietary patterns and dietary antioxidant intake were inversely correlated with serum PAF and PAF synthetic enzyme levels, suggesting the potential for dietary influences on PAF levels. 110 Along these lines, another group looked at lipid profiles and PAF-AH activity in neonates born to women with pre-eclampsia compared with healthy neonates. 111 The neonates of women with severe pre-eclampsia had significantly higher PAF-AH activity and lipid profile changes suggestive of chronic inflammation.…”

Energy Intake and Plasma Adiponectin as Potential Determinants of Lipoprotein‐Associated Phospholipase A2 Activity: A Cross‐Sectional Study

“…Additionally, the association of Lp‐PLA 2 activity with adiponectin is either insignificant in men and women without incident CHD in a nested case–control study among participants of the EPIC‐Norfolk cohort, or is negative in obese adolescents with and without T2DM (Rana et al, ; Seyfarth et al, ). Finally, the anti‐atherogenic role of Lp‐PLA 2 due to the inactivation of PAF and oxidized phospholipids should be considered, and we have previously demonstrated that among PAF metabolic enzymes, increased Lp‐PLA 2 activity constitutes a distinct metabolic pattern in apparently healthy volunteers, even though PAF levels were not correlated with Lp‐PLA 2 activity (Detopoulou et al, ).…”

“…In relation to lifestyle factors, the association of Lp-PLA 2 activity with smoking remains inconclusive (Acevedo et al, 2015;Persson et al, 2007a;Tselepis et al, 2009). In observational studies, Lp-PLA 2 activity is not significantly associated with the physical activity level (Rana et al, 2011;Steffen et al, 2013;Tselepis et al, 2009;Tsimikas et al, 2009), consumption of foods (Tselepis et al, 2009) and food groups (Detopoulou et al, 2015;Tselepis et al, 2009), or intake of total energy and macronutrients (Detopoulou et al, 2015;Tsimikas et al, 2009). In contrast, intervention studies showed that dietary modifications and/ or lipid-lowering agents that improved lipid profile could also influence Lp-PLA 2 activity (Silva et al, 2011).…”