The Relation of Body Mass Index to Biochemical Parameters and Profile of Heart Failure

Aursulesei, Viviana; Manta, Andrei; Namat, Razan Al; Hugianu, Monica; Moloce, Angela Maria; Aursulesei, Victor Cristian; Craiu, Mihai

doi:10.37358/rc.18.7.6392

Cited by 1 publication

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“…However, there are some important limitations that should be taken into account when interpreting natriuretic peptide values. Obese patients with heart failure frequently have lower values of cardiac natriuretic peptides [1,2]; an inverse linear relationship between BMI and natriuretic peptide values was described, as we also demonstrated in previous studies [2,9,10]. Regarding atrial fibrillation, NT-proBNP values are increased in patients with this comorbidity, proving potentially useful in stratifying risk, defining prognosis and even making therapeutic decision [1,11].…”

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confidence: 71%

Can the Presence of Atrial Fibrillation Influence the Levels of Heart Failure - Specific Biomarkers in Overweight and Obese Patients With Heart Failure?

Dădârlat¹,

Pop²,

Fărcăş³

et al. 2019

Rev. Chim.

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Heart failure continues to be a major worldwide medical issue, associated with high morbidity and mortality. The need for ideal biomarkers to aid the diagnosis and prognosis in certain situations, such as obesity or atrial fibrillation is still ongoing. Obese patients are commonly hyperleptinemic. The aim of the study is to assess the role of several biomarkers in overweight and obese patients diagnosed with heart failure, depending on the presence or absence of atrial fibrillation and also their relationship with leptin. The study included 88 overweight and obese patients, with a body mass index (BMI) ≥25 kg/m2, admitted for worsening heart failure. Of these, 52.2% had atrial fibrillation. Dosage of NT-proBNP was performed using the chemiluminescence method. MR-proANP, galectin-3 and leptin were dosed using the ELISA method. A value of P [0.05 was defined as statistically significant. The values of natriuretic peptides NT-proBNP and MR-proANP were significantly increased. Only NT-proBNP was significantly influenced by renal function. No statistically significant correlation was found between heart failure-specific biomarkers and leptin secretion. There were no significant differences in the biomarkers levels between the 2 groups of patients. No statistically significant correlation was found between heart failure-specific biomarkers and leptin secretion. Obese patients with heart failure had significantly increased values of all the studied parameters, but the presence of atrial fibrillation did not influence their levels. High leptin levels were not directly correlated with the levels of heart failure-specific biomarkers.

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