The relation of arterial pulse pressure to the hemodynamics of arterial hypertension

Weiss, Soma; Haynes, Florence W.; Shore, Rose

doi:10.1016/s0002-8703(36)90228-4

Cited by 9 publications

(1 citation statement)

References 21 publications

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“…In some of the studies, however, there is no demonstration of a correlation between PWV and blood pressure values (12,15) and in other investigations there is no agreement as to whether the PWV is most dependent upon the systolic blood pressure, the diastolic blood pressure (13,16), both the systolic and diastolic blood pressures (7), or the pulse pressure (17).…”

Section: Principles Of Measurementmentioning

confidence: 99%

Pressure Wave Velocity in the Human Aorta*

Nielsen

Fabricius

1968

J American Geriatrics Society

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After introduction of a catheter into the aorta, the pressure wave velocity was measured in 26 subjects whose ages ranged from 9 to 68 years. The first site of registration was approximately 10 cm from the aortic valve, and the second was 50 cm distal to the first. At both sites the time difference was measured between the R‐wave of the electrocardiogram and the foot of the pressure wave (TProx. and TDist.). The time difference T50 (TDist. – TProx.) and the distance between the sites of registration (50 cm) were used for the calculation of the pressure wave velocity (PWV). Four of the 26 subjects were normal; the others had some form of heart disease, including disease of the valves, hypertension and aortic atherosclerosis. Nevertheless, the values found for pressure wave velocity were in agreement with those stated in literature. A significant correlation was found between T50 and age (r = —0.788), between T50 and the proximal systolic blood pressure (r = −0.537), and between T50 and the proximal pulse pressure (r = −0.491), but not between T50 and the cardiac output and peripheral arterial resistance. There was no correlation between the proximal diastolic blood pressure and T50, possibly owing to the fact that all the patients had a diastolic blood pressure below 100 mm Hg. There was no significant difference between the coefficient of correlation for T50 and age (−0.788) and the multiple coefficient of correlation for T50 and age and systolic blood pressure proximal in the aorta (−0.811). Four patients had arteriographic aortic atherosclerosis. Two of these had lower T50 values than would be expected according to the proximal systolic blood pressure and the pulse pressure, but after exercise the values were within the normal range (±2 s.d.) Owing to the dominating influence of age on T50 and the considerable spreading of these values, it is not likely that the determination of pulse wave velocity will be of clinical value, for example, in the diagnosis of atherosclerosis.

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Section: Principles Of Measurementmentioning

confidence: 99%