The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters

Bakılan, Fulya; Ortanca, Burcu

doi:10.4274/tod.galenos.2021.66934

Cited by 1 publication

(4 citation statements)

References 34 publications

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“…Eight studies (N = 1,424 patients) found that patients with severe OA had higher NLR levels than patients with mild-moderate OA (MD 0.29, 95% CI 0.12-0.46, p = 0.0007) (Fig. 3A) 33-36,44,45,47,49 . Between-study statistical heterogeneity was substantial (I 2 68%) with ESR being a significant effect modifier on metaregression.…”

Section: Resultsmentioning

confidence: 99%

“…The overall risk of bias among the included studies was variable (Table I). Four studies were deemed to be poor quality 32,35,43,44 , 9 studies were deemed to be fair quality 33,34,38,40-42,45,47,51 , and the remaining 7 studies were rated as high-quality studies 36,37,39,46,48-50 .…”

Section: Resultsmentioning

confidence: 99%

“…Between-study statistical heterogeneity was moderate (I 2 51%) with CRP being a significant effect modifier. Three low-quality studies were removed for sensitivity analysis 35,43,44 . The resulting PLR differences were similar (MD 3.82, 95% CI −2.23 to 9.87, p < 0.0001).…”

Section: Resultsmentioning

confidence: 99%

“…Study design, patient demographics, inflammatory parameters measured, and the type of arthritis reported are detailed in Table I. The 20 studies were published between 2016 and 2022 and included a total of 5,109 patients 32-51 .…”

Section: Resultsmentioning

confidence: 99%

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The Significance of Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio, and Red Cell Distribution Width in Osteoarthritis

Raveendran,

Perry,

Bucknill

et al. 2023

JBJS Journal of Orthopaedics for Physician Assistants

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Background: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) are routinely available inflammatory biomarkers. Their significance in osteoarthritis (OA) is poorly understood. This is a systematic review, and meta-analysis aimed to determine the association of these biomarkers with the presence and severity of OA. Methods: We searched MEDLINE, EMBASE, and Cochrane library for studies reporting on associations between NLR, PLR, and RDW with OA from October 1, 2022, to November 18, 2022. We generated pooled effect measures using random-effects inverse-variance modeling to compare biomarker levels in patients with OA against healthy controls. We generated pooled effect measures to compare patients with severe OA against mild/moderate OA as defined by the Kellgren-Lawrence grading scale, a classification of OA severity based on radiographic findings. We performed metaregression to explore between-study heterogeneity. Results: We included 20 studies involving 5,109 patients in this review. Both NLR and PLR were significantly elevated in OA. RDW was not significantly elevated with OA presence or severity. Only NLR demonstrated a significant elevation with OA severity. Conclusions: In this systematic review and meta-analysis, both NLR and PLR were associated with the presence of OA, whereas only NLR was associated with the severity of disease.

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