The relation between the severity of androgenetic alopecia and cardiovascular atherosclerosis measured via carotid intima-media thickness and the syntax score

ÇÖLGEÇEN, EDE Hüseyin;

doi:10.1501/tipfak_0000000926

Cited by 1 publication

(2 citation statements)

References 16 publications

(23 reference statements)

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“…Also, AGA and cardiovascular disease (CVD) are linked to each other 2 . Some may even regard AGA as a simple marker of subclinical atherosclerosis 3 …”

Section: Introductionmentioning

confidence: 99%

“…2 Some may even regard AGA as a simple marker of subclinical atherosclerosis. 3 Irisin is a novel myokine that is derived from fibronectin type III domain-containing protein 5 (FNDC5) and acts by changing white adipose tissue to brown adipose tissue to enhance systemic metabolism and insulin sensitivity. 4 It is synthesized mainly in skeletal muscle in response to physical exercise, and is also found in cardiac muscle, adipose tissue, liver, brain, bones, sebaceous glands, pancreas, kidneys, and others.…”

Section: Introductionmentioning

confidence: 99%

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Circulating and/or cutaneous irisin resistance: A novel link among androgenetic alopecia, comorbid metabolic syndrome and cardiovascular risks

Dawoud

Hefnawy

et al. 2023

J of Cosmetic Dermatology

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Background: Androgenetic alopecia (AGA) is a common cause of hair loss in both genders that may be associated with disturbed systemic metabolism. Irisin is a hormone-like myokine that greatly influences systemic metabolism and is linked to cardiovascular diseases. Aim:To detect irisin role in AGA and its associated metabolic syndrome (MetS) and cardiovascular risk.Patients/Methods: This case-control study included 44 AGA patients of both genders and 22 healthy individuals. Serum irisin level was measured using ELISA and scalp biopsy was taken to detect irisin immunohistochemically. Carotid Doppler ultrasonography was performed to measure carotid intima media thickness (CIMT).Results: Higher serum irisin was significantly detected in AGA patients (p ˂ 0.001), and in males (p = 0.01) particularly severe cases (p ˂ 0.001). It was significantly higher in AGA patients presenting with MetS and those suffering from dyslipidemia (p ˂ 0.001 for both). Multivariate regression analysis proved BMI (p = 0.01) and serum irisin (p = 0.02) as independent predictors of CIMT abnormality among AGA patients.Regarding cutaneous irisin expression, the epidermal H-score was significantly higher in AGA patients with MetS compared to those without (p = 0.04). Epidermal H-score ˃100 was significantly associated with male gender (p = 0.05), severe AGA (p = 0.02), MetS (p = 0.03), dyslipidemia (p = 0.03), and abnormal CIMT (p = 0.03). Conclusion:High serum irisin and upregulated epidermal irisin expression are associated with the incidence of MetS, dyslipidemia, and CIMT abnormality among AGA patients. This may indicate resistance to irisin, which hinders its favorable cardiometabolic actions. Further studies are warranted to investigate the concept of irisin resistance in AGA patients, which was uniquely discussed in the present study.

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“…Also, AGA and cardiovascular disease (CVD) are linked to each other 2 . Some may even regard AGA as a simple marker of subclinical atherosclerosis 3 …”

Section: Introductionmentioning

confidence: 99%