The Relation between the Rheological Properties of Gels and the Mechanical Properties of Their Corresponding Aerogels

Sun, Mingze; Sun, Huarui; Wang, Yutao; Sánchez‐Soto, Miguel; Schiraldi, David A.

doi:10.3390/gels4020033

Cited by 34 publications

(27 citation statements)

References 19 publications

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“…High G′ value reflects elastic or highly structured thermo-responsive cellulose hydrogel [ 35 ]. On the other hand, η* is an overall resistance to deformation, and it is a function of complex shear modulus (G*) [ 36 ]. G* is sum of the elastic and viscous components of the thermo-responsive cellulose hydrogel, represented by G′ and loss modulus (G″), respectively.…”

Section: Methodsmentioning

confidence: 99%

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Al-Rajabi

Teow

2021

Polymers

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Drug delivery is a difficult task in the field of dermal therapeutics, particularly in the treatment of burns, wounds, and skin diseases. Conventional drug delivery mediums have some limitations, including poor retention on skin/wound, inconvenience in administration, and uncontrolled drug release profile. Hydrogels able to absorb large amount of water and give a spontaneous response to stimuli imposed on them are an attractive solution to overcome the limitations of conventional drug delivery media. The objective of this study is to explore a green synthesis method for the development of thermo-responsive cellulose hydrogel using cellulose extracted from oil palm empty fruit bunches (OPEFB). A cold method was employed to prepare thermo-responsive cellulose hydrogels by incorporating OPEFB-extracted cellulose and Pluronic F127 (PF127) polymer. The performance of the synthesized thermo-responsive cellulose hydrogels were evaluated in terms of their swelling ratio, percentage of degradation, and in-vitro silver sulfadiazine (SSD) drug release. H8 thermo-responsive cellulose hydrogel with 20 w/v% PF127 and 3 w/v% OPEFB extracted cellulose content was the best formulation, given its high storage modulus and complex viscosity (81 kPa and 9.6 kPa.s, respectively), high swelling ratio (4.22 ± 0.70), and low degradation rate (31.3 ± 5.9%), in addition to high t50% value of 24 h in SSD in-vitro drug release to accomplish sustained drug release. The exploration of thermo-responsive cellulose hydrogel from OPEFB would promote cost-effective and sustainable drug delivery system with using abundantly available agricultural biomass.

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Section: Methodsmentioning

confidence: 99%

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Al-Rajabi

Teow

2021

Polymers

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“…Contrary to this, the elastic portion of the deformed material, in an elastic material, stores the energy. Storage modulus or G′ embodies this stored deformation energy while the loss modulus G″ exemplifies the deformation energy which is dissipated or lost due to internal friction in a flowing fluid [ 41 , 43 ]. Thus, in the present study, post-gelation in situ nanoemulgel is a viscoelastic solid that has G′ > G″ (higher storage modulus than loss modulus) ( Figure 4 C).…”

Section: Resultsmentioning

confidence: 99%

Ion-Triggered In Situ Gelling Nanoemulgel as a Platform for Nose-to-Brain Delivery of Small Lipophilic Molecules

et al. 2021

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Background: Intranasal route offers a direct nose-to-brain delivery via olfactory and trigeminal nerves and minimizes the systemic exposure of the drug. Although reliable and non-invasive, intranasal administration of lipophilic neuroprotective agents for brain targeting is still challenging. Literature focuses on naturally-derived compounds as a promising therapeutics for chronic brain diseases. Naringin, a natural flavonoid obtained from citrus fruits possesses neuroprotective effects. By regulating multiple crucial cellular signaling pathways, naringin acts on several therapeutic targets that make it suitable for the treatment of neurodegenerative diseases like Alzheimer’s disease and making it a suitable candidate for nasal administration. However, the hydrophobicity of naringin is the primary challenge to formulate it in an aqueous system for nasal administration. Method: We designed a lipid-based nanoemulsifying drug delivery system of naringin using Acrysol K140 as an oil, Tween 80 as a surfactant and Transcutol HP as a cosolvent, to improve solubility and harness the benefits of nanosizing like improved cellular penetration. Intranasal instillations of therapeutic agents have limited efficacy due to drug washout and inadequate adherence to the nasal mucosa. Therefore, we reconstituted the naringin self-emulsifying system in a smart, biodegradable, ion-triggered in situ gelling hydrogel and optimized for desirable gel characteristics. The naringin-loaded composition was optimized and characterized for various physicochemical and rheological properties. Results: The formulation showed a mean droplet size 152.03 ± 4.6 nm with a polydispersity index <0.23. Ex vivo transmucosal permeation kinetics of the developed formulation through sheep nasal mucosa showed sustained diffusion and enhanced steady-state flux and permeability coefficient. Scanning and transmission electron microscopy revealed the spherical shape of emulsion droplets and entrapment of droplets in a gel structure. The formulation showed excellent biocompatibility as analyzed from the viability of L929 fibroblast cells and nasal mucosa histopathology after treatment. In vivo biodistribution studies revealed significantly higher drug transport and brain targeting efficiency. Conclusion: In situ gelling system with nanoemulsified naringin demonstrated a safe nasal delivery providing a new dimension to the treatment of chronic neurodegenerative diseases using small hydrophobic phytoconstituents with minimization of dose and related systemic adverse effects.

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“…6). With further treatment, G′, G″, and η* of AP started to decline, reflecting a general decrease of the strengths of the AP gels (Franck, 2004;Sun, Sun, Wang, Sánchez-Soto, & Schiraldi, 2018).…”

Section: Rheological Characteristicsmentioning

confidence: 99%

“…Samples treated for 3-4 min exhibited higher tan δ than the original granules, indicating the formation of a plastic gel system (Franck, 2004;Sun, et al, 2018). Although 5-6 min of microwave treatment showed low tan δ at low frequency, they had the highest increase in tan δ with increased frequency, hence showing the strongest deformability of the AP granules.…”

Section: Rheological Characteristicsmentioning

confidence: 99%

Influence of microwave treatment on the structure and functionality of pure amylose and amylopectin systems

et al. 2021

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Pure granular amylose (AM) and pure granular amylopectin (waxy) starch (AP) granules have the high nutritional value in food industry. Effects of microwave treatment (400 W / g DW, 1-8 min) on the structure and properties of transgenic AM granules and AP granules were investigated in direct comparison. Microwave treatment, especially during the first three minutes, decreased the molecular weight of molecules in both the AM and the AP samples. The crystallinity of AM starch initially increased from 15.6% to 20.6%, which was associated with the formation of new Vh-type crystals. After that, crystallinity decreased alongside to 11.3% with the complete disruption of B-type crystals. In contrast, the crystallinity of AP starch initially decreased from 18.9% to 10.8% followed by an increase to 20.0%. Upon prolonged treatment of AM granules, the resistant starch and water solubility was significantly increased.Our data demonstrate notable different microwave-dependent reorganization patterns for pure granular AM and AP molecules as native granular systems, which is helpful to the improvement of functionality of these two starches.

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The Relation between the Rheological Properties of Gels and the Mechanical Properties of Their Corresponding Aerogels

Cited by 34 publications

References 19 publications

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Ion-Triggered In Situ Gelling Nanoemulgel as a Platform for Nose-to-Brain Delivery of Small Lipophilic Molecules

Influence of microwave treatment on the structure and functionality of pure amylose and amylopectin systems

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