The relation between the levels of osteoprotegerin and the degree of coronary artery disease in patients with acute coronary syndrome and stable angina pectoris

Abstract

A b s t r a c tBackground: Osteoprotegerin (OPG), an inhibitor of osteoclastogenesis, has recently been under the spotlight in studies regarding the pathophysiology of atherosclerosis. Aim:To evaluate the value of serum OPG in the diagnosis and severity in patients with stable angina pectoris (SA) and unstable angina pectoris/non ST elevation myocardial infarction. Methods:This study involved 160 patients, SA (n = 65), acute coronary syndrome (NSTE-ACS; n = 65), and a control group (n = 30). Blood samples were collected in the first hour, after 24 hours and on the fifth day. The prevalence of coronary artery atherosclerotic lesions was determined using the Gensini scoring system.Results: A statistically significant difference was observed in the first hour OPG levels between the control group and both the SA and NSTE-ACS group (p < 0.001). When the cut-off value was determined as 247.71 pg/mL, the sensitivity and specifi city of the first hour OPG levels indicating coronary artery disease were 91.54% and 46.67%, respectively, while the positive predictive value was 88.1% and the negative predictive value was 56%. No correlations were observed between the first, 24 th hour and the fifth day OPG levels and the Gensini scores. No relation was denoted between the OPG levels and number of diseased coronary arteries. Conclusions:In our study, serum OPG level seemed to be unrelated to the severity or the degree of coronary artery disease in patients with SA and unstable angina pectoris/non ST elevation myocardial infarction. OPG may only be accepted as an indicator of coronary artherosclerosis. Copyright © Polskie Towarzystwo Kardiologiczne INTRODUCTION Coronary atherosclerosis is the most common form of cardiovascular disease, with high mortality and morbidity rates. Arterial calcification has been found to be related to an increased risk of cardiovascular events, although the predictive value of coronary risk factors remains unclear [1].

Correlations between Vascular Stiffness Indicators, OPG, and 25-OH Vitamin D3 Status in Heart Failure Patients

“…In our study, mean serum OPG levels were higher in patients with HF and CAD compared to CON ( p < 0.001). These results are in line with similar published findings [18,19,20].…”

“…They concluded that serum OPG levels had a long-lasting independent predictive power for all-cause mortality and cardiovascular death in these patients [18]. Aksu et al sustained that increased OPG could be accepted as a biomarker of coronary atherosclerosis [19]. In our study, mean serum OPG levels were higher in patients with HF and CAD compared to CON ( p < 0.001).…”

Effects of 17β-estradioland raloxifene on endothelial OPG and RANKL secretion

“…In contrast, in humans many authors suggest a positive association between serum OPG and atherosclerosis, arterial calcification, or CV disease [24]. High serum concentrations of OPG were correlated to the severity of peripheral arterial disease [25] and heart failure [26], unstable angina [27], acute myocardial infarction and risk of death [28]. Bjerre [29] reports that increased levels of OPG are not directly involved with the extent of myocardial injury.…”

The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox

“…In the control group, which consisted of healhy subjects, the OPG and OPG/RANK-L levels were significantly lower than those of both the ACS and the SAP groups ( 52 ). However, in another study involving patients with SAP, USAP, and non-STEMI, the OPG levels showed no correlation with the severity of CAD, which might be due to OPG and/or RANK-L polymorphism and some other possible genetic variations, but it may be accepted as an indicator of coronary atherosclerosis ( 53 ). Higher OPG levels detected in patients with ACS might be associated with increased cytokine levels.…”