The relation between serum irisin levels with the anthropometric and metabolic parameters in obese and non-obese patients with type 2 diabetes mellitus

Abstract

Background: The browning of white adipose tissue caused by irisin, which has a role in thermogenesis. The purpose of this research was to assess the irisin in individuals with type 2 diabetes mellitus (T2DM), comparing obese and non-obese patients, to evaluate its correlation with metabolic and anthropometric parameters. Methods: This survey work setting was done on 200 patients with clinical criteria of type two diabetes mellitus. Patients were categorized in to 2 groups according to body mass index (BMI): group I: 94 patients with obese type 2 DM and Group II: 106 patients with non-obese type 2 DM. Detection and quantification of Irisin in human and mouse plasma, serum, urine, cell, and tissue lysates were performed using Irisn Elisa Kits. Results: A significant positive correlation was between irisin levels and anthropometric measures. Conversely, a significant negative correlation was found between irisin levels and indicators of fat-free mass. There was an insignificant correlation between irisin and parameters as (Height, systolic BP, diastolic BP, total cholesterol, triglycerides, HDL and LDL). Conclusion:The elevation in irisin levels in individuals with obesity may suggest a physiological role in enhancing glucose tolerance, a common impairment observed in obese individuals. However, this compensatory irisin secretion seems to transition towards a state of inadequate secretion as diabetes develops. Irisin has the ability to have beneficial effects on glucose and insulin levels.