The relation between retinopathy and albumin excretion rate in insulin‐dependent diabetes mellitus

Johansen, Jens Brock; Sjølie, Anne Katrin; Elbøl, P.; Eshøj, O.

doi:10.1111/j.1755-3768.1994.tb02771.x

Cited by 15 publications

(3 citation statements)

References 11 publications

(9 reference statements)

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“…The prevalence of retinopathy and visual handicap has been described in several adult populationbased studies (Klein et al 1984;Nielsen 1984;Sjalie 1985;Jerneld 1988;Parving et al 1988;Cruickshanks et al 1993;Johansen et al 1994). High prevalence rates of low degree myopia have also been found in young diabetic adults (Fledelius 1983(Fledelius , 1986Sjalie 1985Sjalie ,1991.…”

mentioning

confidence: 94%

Refraction and retinopathy in diabetic children below 16 years of age

Johansen

Sjølie

Eshøj

1994

Acta Ophthalmologica

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In a population-based cross-sectional study of insulin-dependent diabetes mellitus, 42 children--with a median age of 11 years (range 7-15 years) and a median duration of diabetes of 4 years (range 1-12 years)--underwent an ophthalmological and a biochemical examination (HbA1c). None of the children had visual loss due to diabetes, and only 4.8% had mild, non-proliferative retinopathy. Using cycloplegic refractioning, we found low degree myopia (less than -2D) in 12% of the patients, whereas non-mydriatic measurements increased the frequency of myopia to 29%. We therefore recommend the use of cycloplegia in refractive evaluations of diabetic children.

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confidence: 94%

Refraction and retinopathy in diabetic children below 16 years of age

Johansen

Sjølie

Eshøj

1994

Acta Ophthalmologica

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“…The disease is classified into type I diabetes (previously referred to as “insulin dependent” or “juvenile onset”), characterized by an absolute insulin deficiency as a consequence of destruction of the insulin secretory pancreatic β cells of the islets of Langerhans; and type II diabetes (“non-insulin dependent” adult-onset” which is characterized by an insulin secretory defect of the β-cell and insulin resistance in peripheral tissues. Diabetic retinopathy is a common complication of both type I (50% incidence) and type II (30% incidence)[22], [23], [24], [25], [26] diabetes. Diabetic retinopathy can be broadly divided into two clinical stages: non-proliferative and proliferative diabetic retinopathy (PDR).…”

Section: Discussionmentioning

confidence: 99%

Betacellulin Induces Increased Retinal Vascular Permeability in Mice

et al. 2010

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BackgroundDiabetic maculopathy, the leading cause of vision loss in patients with type 2 diabetes, is characterized by hyper-permeability of retinal blood vessels with subsequent formation of macular edema and hard exudates. The degree of hyperglycemia and duration of diabetes have been suggested to be good predictors of retinal complications. Intervention studies have determined that while intensive treatment of diabetes reduced the development of proliferative diabetic retinopathy it was associated with a two to three-fold increased risk of severe hypoglycemia. Thus we hypothesized the need to identify downstream glycemic targets, which induce retinal vascular permeability that could be targeted therapeutically without the additional risks associated with intensive treatment of the hyperglycemia. Betacellulin is a 32 kD member of the epidermal growth factor family with mitogenic properties for the retinal pigment epithelial cells. This led us to hypothesize a role for betacellulin in the retinal vascular complications associated with diabetes.Methods and FindingsIn this study, using a mouse model of diabetes, we demonstrate that diabetic mice have accentuated retinal vascular permeability with a concomitant increased expression of a cleaved soluble form of betacellulin (s-Btc) in the retina. Intravitreal injection of soluble betacellulin induced retinal vascular permeability in normoglycemic and hyperglycemic mice. Western blot analysis of retinas from patients with diabetic retinopathy showed an increase in the active soluble form of betacellulin. In addition, an increase in the levels of A disintegrin and metalloproteinase (ADAM)-10 which plays a role in the cleavage of betacellulin was seen in the retinas of diabetic mice and humans.ConclusionsThese results suggest that excessive amounts of betacellulin in the retina may contribute to the pathogenesis of diabetic macular edema.

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“…In 138 patients with insulin-dependent diabetes mellitus aged between 25 and 34 years with onset before 30 years of age, it was found that nephropathy was rare in patients without retinopathy, but retinopathy was often seen in patients without nephropathy. In both cases, DR was often detected earlier than DN in patients with insulin-dependent diabetes mellitus (202). This may be due to the higher vulnerability of the retina compared to the kidneys and the higher detection rate of DR, as fundus photography or fundography is more accessible to perform and therefore allows for easier detection compared to renal biopsy (203).…”

Section: With Dr Without Dnmentioning

confidence: 99%

Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy

Tang,

An,

Sun

et al. 2024

Front. Endocrinol.

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Diabetic nephropathy (DN) and diabetic retinopathy (DR), as microvascular complications of diabetes mellitus, are currently the leading causes of end-stage renal disease (ESRD) and blindness, respectively, in the adult working population, and they are major public health problems with social and economic burdens. The parallelism between the two in the process of occurrence and development manifests in the high overlap of disease-causing risk factors and pathogenesis, high rates of comorbidity, mutually predictive effects, and partial concordance in the clinical use of medications. However, since the two organs, the eye and the kidney, have their unique internal environment and physiological processes, each with specific influencing molecules, and the target organs have non-parallelism due to different pathological changes and responses to various influencing factors, this article provides an overview of the parallelism and non-parallelism between DN and DR to further recognize the commonalities and differences between the two diseases and provide references for early diagnosis, clinical guidance on the use of medication, and the development of new drugs.

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The relation between retinopathy and albumin excretion rate in insulin‐dependent diabetes mellitus

Cited by 15 publications

References 11 publications

Refraction and retinopathy in diabetic children below 16 years of age

Refraction and retinopathy in diabetic children below 16 years of age

Betacellulin Induces Increased Retinal Vascular Permeability in Mice

Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy

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