The relation between protein Z polymorphism and the risk of thrombosis in Egyptian patients with antiphospholipid syndrome

Eissa, Yomna K.; Ellithy, Hend N.; Yousry, Sherif M.; Ismail, Zakaria

doi:10.1016/j.hemonc.2018.03.005

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…For the diagnosis of TAPS, Yomna K et al found that protein Z-79 G/A gene polymorphism could prevent APS thrombosis (68). Plasin Rodriguez et al also tested PROCR, the gene encoding endothelial cell protein C receptor.…”

Section: Differential Diagnosis Of Aps Subtypesmentioning

confidence: 99%

High-throughput sequencing technology facilitates the discovery of novel biomarkers for antiphospholipid syndrome

et al. 2023

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Antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis and/or morbid pregnancy, accompanied by persistent antiphospholipid antibody (aPL) positivity. However, due to the complex pathogenesis of APS and the large individual differences in the expression of aPL profiles of patients, the problem of APS diagnosis, prognosis judgment, and risk assessment may not be solved only from the antibody level. It is necessary to use new technologies and multiple dimensions to explore novel APS biomarkers. The application of next-generation sequencing (NGS) technology in diseases with a high incidence of somatic mutations, such as genetic diseases and tumors, has been very mature. Thus, we try to know the research and application progress of APS by NGS technology from genome, transcriptome, epigenome and other aspects. This review will describe the related research of NGS technology in APS and provide more reference for the deep understanding of APS-related screening markers and disease pathogenesis.

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Section: Differential Diagnosis Of Aps Subtypesmentioning

confidence: 99%

High-throughput sequencing technology facilitates the discovery of novel biomarkers for antiphospholipid syndrome

et al. 2023

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Amniotic Fluid Proteomics Analysis and In Vitro Validation to Identify Potential Biomarkers of Preterm Birth

Chen,

Wang,

Yan

et al. 2024

Reprod. Sci.

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This study aimed to investigate the regulation of amniotic fibroblast (AFC) function by vitamin K–dependent protein Z (PROZ) during preterm birth (PTB) and its potential role in adverse pregnancy outcomes. Proteomic samples were collected from amniotic fluid in the second trimester, and AFC were isolated from the amniotic membrane and cultured in vitro. The expression of extracellular and intracellular PROZ in AFC was modulated, and their biological properties and functions were evaluated. Clinical analysis revealed a significant upregulation of PROZ expression in amniotic fluid from preterm pregnant women. In vitro experiments demonstrated that PROZ stimulated AFC migration, enhanced their proliferative capacity, and reduced collagen secretion. Overexpression of PROZ further enhanced cell migration and proliferation, while knockdown of PROZ had the opposite effect. PROZ plays a crucial role in promoting the proliferation and migration of amniotic membrane fibroblasts. Increased PROZ expression in amniotic fluid is associated with the occurrence of PTB. These findings shed light on the potential involvement of PROZ in adverse pregnancy outcomes and provide a basis for further research on its regulatory mechanisms during PTB.

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Antiphospholipid syndrome's genetic and epigenetic aspects

Iuliano

Gargiulo

Sebastiani

2019

Autoimmunity Reviews

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The relation between protein Z polymorphism and the risk of thrombosis in Egyptian patients with antiphospholipid syndrome

Abstract: Protein Z-79 G/A gene polymorphism may be of a protective value against thrombosis in APS. The G79A polymorphism of protein Z was not found to be an independent risk factor of thrombosis in APS.

Cited by 5 publications

References 22 publications

High-throughput sequencing technology facilitates the discovery of novel biomarkers for antiphospholipid syndrome

High-throughput sequencing technology facilitates the discovery of novel biomarkers for antiphospholipid syndrome

Amniotic Fluid Proteomics Analysis and In Vitro Validation to Identify Potential Biomarkers of Preterm Birth

Antiphospholipid syndrome's genetic and epigenetic aspects

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