The Relation Between Microflora and Innate Immunity Responses in Mucosa- Associated Lymphoid Tissue

Добродеева, Л. К.; Самодова, А. В.; Patrakeeva, V. P.

doi:10.17238/issn2308-3174.2015.2.71

Cited by 2 publications

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“…Similar to immunoglobulins of other classes, reagins have a protective role, but unlike other defense mechanisms, the IgE response is almost instantaneous. It has been previously confirmed that individuals living in northern territories have an increased concentration of reagins in the serum, and a relationship between increased IgE levels with a reduction in daylight hours has been revealed (Dobrodeeva et al, 2013). The reactive defense mechanism is more intense and predominantly cytotoxic (Umryukhin, 2013).…”

Section: Discussionmentioning

confidence: 93%

Distinctive aspects of the immune status of the Kola Saami and Russians living in the Far North

Gubkina

Самодова

Dobrodeeva

2023

American J Hum Biol

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ObjectiveThe level of immunological reactivity of the indigenous inhabitants of the Far North may depend on the extreme‐discomfort factors of the climatic environment and genetic traits of the population. Therefore, the aim of this study was to identify the distinctive elements of the immune status of the Kola Saami and Russians living in the Far North (Murmansk Region).MethodsA complex immunological study of peripheral venous blood composition was performed and involved 67 Saami and 81 Russian inhabitants of the Far North (Murmansk Region) who were aged 21–55. Blood was collected from the cubital vein on an empty stomach in the morning. For the peripheral venous blood, we obtained a hemogram and phagocytic activity of neutrophils, determined the content of lymphocytes with CD4, CD8, CD16, and CD71 phenotypes by indirect immunoperoxidase reaction and flow cytometry using an Epics XL apparatus (Beckman Coulter, United States), obtained concentrations of IL‐6, IFN‐γ, IL‐10, IgA, M, G, E, sCD54, and sCD62L, transferrin, and sCD71 by enzyme immunoassay using the “Evolis” enzyme immunoassay analyzer from Bio‐RAD (Germany), and obtained circulating immune complexes by precipitation using 3.5%, 4.0%, and 7.5% PEG‐6000. The sIgA content was determined in morning saliva, urine, and gastrointestinal tract secretions. The results were analyzed using descriptive statistics, independent sample t‐criterion, and Pearson correlation coefficient.ResultsA decrease in the total number of leukocyte cells in the Saami was associated with a high incidence of leukopenia, lymphopenia, and neutropenia. Deficiency in active phagocytes and serum IgA and sIgA concentrations was revealed as well as increased contents of CD4+ and CD8+ receptor lymphocytes, membrane and free adhesion molecules, and transferrin. Leukocytosis, lymphocytosis, neutrophilia, monocytosis, and eosinophilia with increased contents of natural killer cells, IL‐6, and IL‐10 were recorded more frequently in the Russians. High levels of IgE and IFN‐γ, which have the most pronounced cytotoxicity and are indicative of strained immune mechanisms, were characteristic of the Saami and Russians.ConclusionThe distinctive aspects of the immune status of the Kola Saami is related to the deficit in the active phagocyte and serum IgA and sIgA concentrations as well as the increase in the contents of cytotoxic lymphocytes, intercellular adhesion molecules, transferrin, and IFN‐γ proinflammatory cytokines. The Russian inhabitants of the Far North are characterized by an adaptive response manifested by an increase in antibody‐dependent cytotoxicity, involving IL‐6 and IL‐10.

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Section: Discussionmentioning

confidence: 93%

Distinctive aspects of the immune status of the Kola Saami and Russians living in the Far North

Gubkina

Самодова

Dobrodeeva

2023

American J Hum Biol

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Experimental Analysis of Ways of Viral Infections Into the Human Body

et al. 2022

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The aim: The aim of the study is to experimentally test the process of viral infection and determine the ways of its penetration into the human body. Materials and methods: This experimental analysis is based on systematic research, published peer-reviewed articles, books, textbooks, monographs. It should also be noted that in order to identify some immunocompetent lymph node cells and the ability to visualize certain sites in the lymphoid nodes of Peyer’s patches, where the initial processes are presented below, we resorted to sampling anatomical material. The study involved 10 adult albino rats weighing 200.0 ± 20.0 g. The search period covered the period from 2010 to 2021, but the experimental analysis contains some valuable data from previous years, as these literature sources have significant scientific value. Results: According to immunohistochemical analysis of the epithelium associated with the dome of the lymph nodes of the small intestine of white rats, the bulk was B-lymphocytes (about 47%) and T-lymphocytes (about 35%), while plasma cells, macrophages and dendritic cells accounted for approximately 5% for each of them. Conclusions: Рrocess of development of viral infection can be represented in the form of the following targeted steps: 1) massive invasion of viruses into the body; 2) the pathway of viruses to the intended target (target cells) is carried out by the blood flow; 3) аchieving the target by viruses and their penetration into target cells. Іn the pathogenesis of viral diseases, the role is played by the preparedness of the particular body, which directly depends on the functional state of its immune system, which determines the possibility, severity and outcome of the disease.

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The Relation Between Microflora and Innate Immunity Responses in Mucosa- Associated Lymphoid Tissue

Cited by 2 publications

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Distinctive aspects of the immune status of the Kola Saami and Russians living in the Far North

Distinctive aspects of the immune status of the Kola Saami and Russians living in the Far North

Experimental Analysis of Ways of Viral Infections Into the Human Body

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