The relation between liver histopathology and GGT levels in viral hepatitis: More important in hepatitis B

Eminler, Ahmet Tarık; İrak, Kader; Ayyildiz, Talat; Keskin, Murat; Kıyıcı, Murat; Gürel, Selım; Gülten, Macit; Dolar, Enver; Nak, Selim Giray

doi:10.5152/tjg.2014.3693

Cited by 30 publications

(33 citation statements)

References 14 publications

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“…30 Significant relationship between liver inflammation and the level of GGT was also found in patients with CHB. 29,31 As previously reported, the AUROC of GGT was similar to that of ALT and AST, and a normal GGT excluded significant liver inflammation with 82% certainty. 12 Therefore, these data suggested that GGT was associated with liver inflammation.…”

Section: Discussionsupporting

confidence: 65%

A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B

Wang

Xia

Zhang

et al. 2018

Journal of Viral Hepatitis

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Identifying the degree of liver inflammation is critical for therapeutic judgement of patients with chronic hepatitis B (CHB). However, we lack indexes which can accurately predict significant liver inflammation in patients with CHB. This study aimed to develop a simple predictive index for liver inflammation in CHB using routine clinical parameters. A total of 519 patients with CHB who underwent liver biopsy were enrolled and randomly divided into training (n = 346) and validation cohorts (n = 173). Based on routine clinical parameters, gamma-glutamyl transpeptidase (GGT; P = 0.031) and platelets (PLT; P < 0.001) were identified as independent predictors of significant inflammation by multivariable analysis in the training cohort. Accordingly, the GGT to PLT ratio (GPR) was developed to amplify the opposing effects for predicting liver inflammation. In the training cohort, the AUCs of GPR in predicting significant inflammation were 0.791 (95% CI: 0.742-0.839), 0.783 (95% CI: 0.717-0.849) and 0.791 (95% CI: 0.716-0.867) in the entire patients with CHB, HBeAg-positive CHB patients and HBeAg-negative CHB patients, respectively. The diagnostic performance of GPR for significant inflammation was significantly superior to that of alanine aminotransferase (ALT), aspartate transaminase (AST) and GGT in all patients with CHB and HBeAg-positive CHB patients, but was comparable with ALT, AST and GGT in HBeAg-negative CHB patients. In the validation cohort, the diagnostic performance of GPR in assessing significant liver inflammation was also superior to other indexes in all patients with CHB and HBeAg-positive CHB patients, but was comparable with GGT in HBeAg-negative CHB patients. Thus, GPR can be a novel and simple index for predicting significant liver inflammation in CHB, especially for HBeAg-positive CHB.

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Section: Discussionsupporting

confidence: 65%

A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B

Wang

Xia

Zhang

et al. 2018

Journal of Viral Hepatitis

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“…High significant increases were observed in ALT, AST, ALP and GGT at (p≤0.05) in HBV compared with control, these results are in agreement with others [22], [33][34]. ALT and GGT showed the highest increments in HBV infection, it has been stated that moderate elevation (3-20 times) of ALT level usually observed in acute hepatitis, neonatal hepatitis, chronic hepatitis, autoimmune hepatitis, drug induced hepatitis, alcoholic hepatitis [30], [33]. other study deduced that the GGT increment that reflects inflammation in, the liver is superior than ALT ,and that GGT may have a significant role in the clinical, evaluation of HBV [34].…”

Section: Discussionsupporting

confidence: 92%

“…Biomarkers are equally valuable for the estimation and assessment of hepatic disease severity due to HBV infection may alter the levels of certain liver enzymes as a result of hepatocellular damage [32]. High significant increases were observed in ALT, AST, ALP and GGT at (p≤0.05) in HBV compared with control, these results are in agreement with others [22], [33][34]. ALT and GGT showed the highest increments in HBV infection, it has been stated that moderate elevation (3-20 times) of ALT level usually observed in acute hepatitis, neonatal hepatitis, chronic hepatitis, autoimmune hepatitis, drug induced hepatitis, alcoholic hepatitis [30], [33].…”

Section: Discussionsupporting

confidence: 85%

A Correlative Study Between Haematological and Biochemical Parameters in Hepatitis B

Ali¹

2019

IHJPAS

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Hepatitis-B (HBV) is a viral disease cause liver damage, cirrhosis, fibrosis and hepatocellular carcinoma. Present study attempted to elucidate the biochemical and haematological markers other than Australia antigen, of hepatitis,B,vairusV (HBsAg) for better assessment of HBV infection. The present study was conducted on 76 men, 50 of them were found to be HBeAg positive and 26 were negative, mean age was53±5.7years. Haematological parameters such as Absolute Erythrocyte( Abs Eryt), Absolute Leukocyte(Abs Leuk) , Haemoglobin(Hb), Packed Cell Volume(PCV),Mean Corpuscular Volume (MCV), Red Cell Distribution Width (RDW), Mean Corpuscular Haemoglobin (MCH),MCH Concentration(MCHC) ,Neutrophils(Neut) ,Lymphocyte(Lymph), Monocyte(Mono), Eosinophil(Eosin) , Basophil (Baso) , Absolut platelet(Abs.Plt), Red Blood Distribution(RBD)and biochemical markers such as Alanine aminotransferase(ALT), Aspartate aminotransferase(AST), Alkaline phosphatase(ALP), Gamma glutamyl transpeptidase(GGT), Total Bilirubin (T.Bil), Albumin(Alb), C- reactive protein (CRP), Amylase(Amy), Creatinine(Crea), Sodium(Na) , Potassium(K), were estimated for HBV patients and healthy groups.Statically at (P≤ 0.05) Abs Plt was highly significant elevated, Hb, Abs Leuk, Neut%, Lymph% and Eosin% were significant increases while other haematological parameters showed no differences in HBV patients compared with controls. Liver enzymes (ALT, AST, GGT) and T.Bil were highly significant increased, Alb , CRP and Amyl were moderately increased, niether Crea, Na nor K levels have differences in HBV patients compared with controls.ALT has strong positive correlation with Leuk and with Abs Plt in HBV patients. liver enzymes ALT, AST, ALP, GGT, T.Bil and Abs Plt can be used as monitoring markers with the strong correlation between ALT and Abs Plt as an assessment tools for HBV infection.

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“…GGT levels were found to be correlated with histo pathological alteration in many hepatic disorders [45] . The increase in GGT in the present study was an indicator for damaging effect of AA on rat hepatic tissue this could be based on previous reports that find an increase in GGT levels in both human and animals exposed to hepatitis inducing agents, special medication, or chemical toxicant insult [46,47] .…”

Section: Ggt and Total Antioxidant Capacitysupporting

confidence: 55%

Copper (I) Nicotinate complex Abrogates Acrylamide Induced Hepatotoxicity in Male Rats: Biochemical and Histological Studies

El-Sawi

Aldajani

Mohamed

et al. 2019

IJFNS

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This study was conducted as a trail to abrogates acrylamide induced hepatotoxicity in male rats by administration of copper (I) nicotinic acid complex. Animals were divided into 4 groups ;GI: control kept on balanced diet and tap water , GII: Acrylamide group received acrylamide in drinking water (7.5 mg/kg b.w.) for 30 days. GIII: treated with copper (I)-nicotinate complex (400 μg/kg b.w.) after acrylamide intoxication for 30 days and GIV the complex then acrylamide (prophylactic). Results showed significant increase in serum levels of AST, ALT, ALP, GGT and total antioxidant capacity (TAC) in acrylamide group. Moreover a significant increase in tumer markers AFU and TNF-Alpha. while Levels of each of S. total protein and S. albumin were significantly decreased in ACR group compared with control. Histological study showed congestion of central vein in liver section and vacuolation of hepatocytes in ACR group. Anticancer activity using in-vitro cytotoxic assay of Cu (I) Nicotinate complex ; proves the anticancer properties of it comparing with doxorubicin. Treatment with Copper (I)-Nicotinate Complex restored tissue and serological indices concomitantly towards normal levels. These results revealed that Copper (I)-Nicotinate Complex is able to significantly alleviate the hepatotoxicity induced by AA in rats and could be utilized as a potent food additives.

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The relation between liver histopathology and GGT levels in viral hepatitis: More important in hepatitis B

Abstract: Background/Aims: To investigate the relationship between gamma-glutamyl transpeptidase (GGT) levels and histopathological status determined by biopsy in patients with chronic hepatitis B and C. Materials and Methods: Patients with chronic hepatitis B and C who were referred to

Cited by 30 publications

References 14 publications

A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B

A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B

A Correlative Study Between Haematological and Biochemical Parameters in Hepatitis B

Copper (I) Nicotinate complex Abrogates Acrylamide Induced Hepatotoxicity in Male Rats: Biochemical and Histological Studies

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