The relation between insulin‐like growth factor 1 levels and risk of depression in ischemic stroke

Zhang, Wei; Wang, Wo; Kuang, Li

doi:10.1002/gps.4774

Cited by 18 publications

(11 citation statements)

References 30 publications

(52 reference statements)

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“…Evidence provided by Zhang et al indicates that levels of IGF-1 in humans are negatively correlated with the development of post-stroke depression. 42 These are consistent with studies which show that IGF-1 levels are predictors for and/or can protect against other forms of depression and anxiety in rodents, as assessed by forced swim and open field activity. [49][50][51] Interestingly, patients suffering from post-stroke depression have higher levels of high sensitivity C reactive protein (hs-CRP)-an indicator of inflammation.…”

Section: Clinical Connections Between Igf-1 and Ischemic Strokesupporting

confidence: 90%

“…[36][37][38] In addition, lower IGF-1 levels also correlate with exacerbation of stroke damage and neurological deficits. 29,37,42 Although IGF-1 levels can be correlated with essential aspects of assessing a patient's outcome, it is not the only factor. Certainly, age, comorbidities, race, and living conditions contribute to stroke deficits, outcome, and survival.…”

Section: Discussionmentioning

confidence: 99%

“…[49][50][51] Interestingly, patients suffering from post-stroke depression have higher levels of high sensitivity C reactive protein (hs-CRP)-an indicator of inflammation. 42 The levels of hs-CRP are inversely correlated with IGF-1, as they are higher in patients with lower serum IGF-1 levels. 37 Moreover, within this same chronic stroke patient population, lower IGF-1 is associated with higher NIHSS scores, which ties the inflammatory phenotype, IGF-1, and neurological deficits.…”

Section: Clinical Connections Between Igf-1 and Ischemic Strokementioning

confidence: 98%

“…Multiple in vivo and clinical studies agree that lower levels of circulating IGF-1 upon hospital admission correlate with an increase in the NIHSS score in the months following insult. 29,37,42,43 Acute stroke survivors (<6 months post insult) with favorable outcomes on the mRS scale also exhibited significantly higher levels of serum IGF-1 when compared to individuals classified with unfavorable outcomes. 37 In order to better understand the relationship between circulating IGF-1 and post-stroke recovery, Å berg and collaborators have followed a cohort of chronic ischemic stroke survivors in the years following insult.…”

Section: Clinical Connections Between Igf-1 and Ischemic Strokementioning

confidence: 99%

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Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke

Hayes

Valcarcel‐Ares

Ashpole

2021

J Cereb Blood Flow Metab

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Ischemic strokes are highly prevalent in the elderly population and are a leading cause of mortality and morbidity worldwide. The risk of ischemic stroke increases in advanced age, corresponding with a noted decrease in circulating insulin growth factor-1 (IGF-1). IGF-1 is a known neuroprotectant involved in embryonic development, neurogenesis, neurotransmission, cognition, and lifespan. Clinically, several studies have shown that reduced levels of IGF-1 correlate with increased mortality rate, poorer functional outcomes, and increased morbidities following an ischemic stroke. In animal models of ischemia, administering exogenous IGF-1 using various routes of administration (intranasal, intravenous, subcutaneous, or topical) at various time points prior to and following insult attenuates neurological damage and accompanying behavioral changes caused by ischemia. However, there are some contrasting findings in select clinical and preclinical studies. This review discusses the role of IGF-1 as a determinant factor of ischemic stroke outcomes, both within the clinical settings and preclinical animal models. Furthermore, the review provides insight on the role of IGF-1 in mechanisms and cellular processes that contribute to stroke damage.

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Section: Clinical Connections Between Igf-1 and Ischemic Strokesupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Clinical Connections Between Igf-1 and Ischemic Strokementioning

confidence: 98%

Section: Clinical Connections Between Igf-1 and Ischemic Strokementioning

confidence: 99%

See 2 more Smart Citations

Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke

Hayes

Valcarcel‐Ares

Ashpole

2021

J Cereb Blood Flow Metab

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“…Five other factors, that directly influence hemostasis, were reported in six articles, with a total of 4143 patients (Table 4). No sex differences were reported for plasma levels of tissue inhibitor metalloproteinase 1 (TIMP-1) (Zhong et al, 2019) and insulin-like growth factor 1 (IGF-1) (Dong et al, 2014;Zhang et al, 2018) 1 day after stroke, matrix metalloproteinase 2 (MMP2) within 2 days after stroke (Montaner et al, 2001), and matrix metalloproteinase 9 (MMP9) 2 days (Montaner et al, 2001;Zhong et al, 2019) and 1 month after stroke (Abdelnaseer et al, 2017). One study found higher aPS titers (18.7% vs. 12.0% positive) in women compared with men 5 days after ischemic stroke, however, this did not reach statistical significance (Tuhrim et al, 1999).…”

Section: Sex Differences In Other Hemostasis Associated Factorsmentioning

confidence: 99%

Sex Differences in Hemostatic Factors in Patients With Ischemic Stroke and the Relation With Migraine—A Systematic Review

Weerd

Ali

et al. 2021

Front. Cell. Neurosci.

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Background: Women are more affected by stroke than men. This might, in part, be explained by sex differences in stroke pathophysiology. The hemostasis system is influenced by sex hormones and associated with female risk factors for stroke, such as migraine.Aim: To systematically review possible sex differences in hemostatic related factors in patients with ischemic stroke in general, and the influence of migraine on these factors in women with ischemic stroke.Results: We included 24 studies with data on sex differences of hemostatic factors in 7247 patients with ischemic stroke (mean age 57–72 years, 27–57% women) and 25 hemostatic related factors. Levels of several factors were higher in women compared with men; FVII:C (116% ± 30% vs. 104% ± 30%), FXI (0.14 UI/mL higher in women), PAI-1 (125.35 ± 49.37 vs. 96.67 ± 38.90 ng/mL), D-dimer (1.25 ± 0.31 vs. 0.95 ± 0.24 μg/mL), and aPS (18.7% vs. 12.0% positive). In contrast, protein-S (86.2% ± 23.0% vs. 104.7% ± 19.8% antigen) and P-selectin (48.9 ± 14.4 vs. 79.1 ± 66.7 pg/mL) were higher in men. Most factors were investigated in single studies, at different time points after stroke, and in different stroke subtypes. Only one small study reported data on migraine and hemostatic factors in women with ischemic stroke. No differences in fibrinogen, D-dimer, t-PA, and PAI-1 levels were found between women with and without migraine.Conclusion: Our systematic review suggests that sex differences exist in the activation of the hemostatic system in ischemic stroke. Women seem to lean more toward increased levels of procoagulant factors whereas men exhibit increased levels of coagulation inhibitors. To obtain better insight in sex-related differences in hemostatic factors, additional studies are needed to confirm these findings with special attention for different stroke phases, stroke subtypes, and not in the least women specific risk factors, such as migraine.

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Inulin alters gut microbiota to alleviate post‐stroke depressive‐like behavior associated with the IGF‐1‐mediated MAPK signaling pathway

Shao,

Tan,

Pan

et al. 2024

Brain and Behavior

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IntroductionGut microbiota dysbiosis is a key factor of the pathogenesis of post‐stroke depression (PSD). PSD is associated with increased hippocampal neuronal apoptosis and decreased synaptic connectivity. Inulin can be involved in hippocampal neuron protection through the microbiome–gut–brain axis. However, the neuroprotective effects of inulin in PSD are still to be further investigated.MethodsBy utilizing the GEO public database, we identify differentially expressed genes in the hippocampus following inulin intake. This can help us discover key signaling pathways through functional enrichment analysis. Furthermore, we validate the expression levels of signaling molecules in a rat model of PSD and examine the effects of inulin on behavioral changes and body weight. Additionally, conducting a microbiome analysis to identify significantly different microbial populations and perform correlation analysis.ResultsThe intake of inulin significantly up‐regulated mitogen‐activated protein kinase signaling pathway in the hippocampus. Inulin changed in the gut microbiota structure, leading to an increase in the abundance of Lactobacillus and Clostridium_sensu_stricto_1 in the intestines of PSD rats, while decreasing the abundance of Ruminococcus UCG_005, Prevotella_9, Oscillospiraceae, and Clostridia UCG_014. Furthermore, the inulin diet elevated levels of insulin‐like growth factor 1 in the serum, which showed a positive correlation with the abundance of Lactobacillus. Notably, the consumption of inulin‐enriched diet increased activity levels and preference for sugar water in PSD rats, while also reducing body weight.ConclusionThese findings highlight the potential therapeutic benefits of inulin in the management of depression and emphasize the importance of maintaining a healthy gut microbiota for PSD.

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The relation between insulin‐like growth factor 1 levels and risk of depression in ischemic stroke

Abstract: The data showed that low serum IGF-1 levels at admission are associated with a high risk of developing PSD, suggesting that these alterations might be involved in the pathophysiology of depression symptoms in stroke patients.

Cited by 18 publications

References 30 publications

Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke

Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke

Sex Differences in Hemostatic Factors in Patients With Ischemic Stroke and the Relation With Migraine—A Systematic Review

Inulin alters gut microbiota to alleviate post‐stroke depressive‐like behavior associated with the IGF‐1‐mediated MAPK signaling pathway

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