The relation between hostility and concurrent levels of inflammation is sex, age, and measure dependent

Demarble, Julie Boisclair; Moskowitz, D. S.; Tardif, Jean‐Claude; DʼAntono, Bianca

doi:10.1016/j.jpsychores.2014.02.010

Cited by 27 publications

(21 citation statements)

References 76 publications

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“…First, the Cook-Medley Hostility Scale shows similar psychometric properties in both samples. Moreover, we have previously shown the expected positive associations between hostility, metabolic abnormalities, and inflammatory activity [58, 91] in this same sample. Finally, the Francophone community within the greater Montreal region is rather heterogeneous and exposed to Anglophone media and culture.…”

Section: Discussionsupporting

confidence: 56%

Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals

et al. 2016

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BackgroundShorter telomere length (TL) may signal premature cellular aging and increased risk for disease. While depression and psychosocial stress have been associated with shorter telomeres, other psychological risk factors for cardiovascular disease have received less attention.PurposeTo evaluate the association between TL and psychological risk factors (symptoms of anxiety and depression, hostility and defensiveness traits) for heart disease, and to examine whether chronological age and sex moderate the associations observed.Methods132 healthy men and women (Mage = 45.34 years) completed the Marlowe-Crowne Social Desirability Scale, the Beck Depression Inventory II, The Beck Anxiety Inventory and the Cook-Medley Hostility Scale. Relative TL was measured by quantitative polymerase chain reaction (PCR) of total genomic DNA samples. A series of hierarchical linear regressions were performed controlling for pertinent covariates.ResultsShorter TL was observed among individuals high in defensiveness (β = -.221) and depressive symptoms (β = -.213), as well as in those with less hostility (β =.256) and anxiety (β =.220)(all Ps<.05). Psychological variables explained 19% of the variance over and above that explained by covariates (age, sex, exercise, alcohol consumption, systemic inflammation, and 24-hr mean arterial pressure). Age moderated the relation between TL and defensiveness (β =.179, p =.03). Sex did not influence any of the relations.ConclusionsTelomere length is associated with psychological burden though the direction of effect differs depending on the psychological variables under study. Further research is needed to determine the reasons for and implications of these seemingly contradictory findings.

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Section: Discussionsupporting

confidence: 56%

Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals

et al. 2016

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“…This is consistent with the finding that there is no association between hostility and TNF-α serum levels in men, as reported by Boisclair Demarble et al [1]. However, sTNF-R p55 levels correlated significantly (p<0.05) with all BSI subscales: somatization (r=0.203, p=0.021, N=129), obsessive-compulsive (r=0.233, p=0.008, N=129), interpersonal sensitivity (r=0.263, p=0.003, N=129), depression (r=0.187, p=0.033, N=129), anxiety (r=0.230, p=0.009, N=129), hostility (r=0.249, p=0.004, N=129), phobia (r=0.185, p=0.036, N=129), paranoia (r=0.285, p=0.001, N=129), and psychoticism (r=0.206, p=0.019, N=129).…”

Section: Dear Editorssupporting

confidence: 93%

“…Our results support the view of Boisclair Demarble et al [1] that hostility and TNF-α serum levels are not related in men. In addition to the importance of sex and age highlighted by…”

Section: Accepted M Manuscriptsupporting

confidence: 92%

“…Boisclair Demarble et al [1], we would like to emphasize the influence of BMI on the TNF-α system. Based on our data, with regards to TNF-α signaling, we recommend that TNF-α receptors should also be taken into account.…”

Section: Accepted M Manuscriptmentioning

confidence: 85%

“…With great interest and pleasure, we have read the article "The relation between hostility and concurrent levels of inflammation is sex, age, and measure dependent" by Boisclair Demarble et al [1] in the Journal of Psychosomatic Research which reports an association between hostility and TNF-α serum levels in women, but not men. It also gives a comprehensive overview of the somewhat contradictory results regarding cytokine levels and hostility reported in the literature.…”

Section: Dear Editorsmentioning

confidence: 99%

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