The relation between cervical and thoracal disc herniations and multiple sclerosis plaques: a retrospective review

Ocak, Özgül; Çetiner, Mustafa; Zorlu, Yaşar; Şener, Ufuk; Uygur, Murat

doi:10.5455/medscience.2017.06.8632

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The etiology of cord lesions in MS has been questioned by some. 18,19 In 1988, Al-Mefty et al described compressive myelopathic MRI changes in the cervical cord related to degenerative disease in non-MS patients, 20 which have since been firmly established, and similarly seen in traumatic cases. Interestingly, the pathophysiology of MS has been theorized to include traumatic in addition to autoimmune mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…18 Ocak et al reported that the presence of cervical disc herniations and MS plaques were correlated and occurred at the same levels, suggesting that the plaques were caused by disc herniation and micro-trauma. 19 Studies of cervical spine biomechanics in football players have demonstrated lesions in the spinal cord even in the absence of bone or joint injuries, 21 in theory supporting an "occult trauma" mechanism in MS. However, most spinal cord lesions in our study were located at different levels from the sites of DDD.…”

Section: Discussionmentioning

confidence: 99%

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MRI Markers of Degenerative Disc Disease in Young Patients With Multiple Sclerosis

et al. 2023

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Background and Purpose: Evidence has emerged for an association between degenerative disc disease (DDD) and multiple sclerosis (MS). The purpose of the current study is to determine the presence and extent of cervical DDD in young patients (age <35) with MS, an age cohort that is less well studied for these changes. Methods: Retrospective chart review of consecutive patients aged <35 referred from the local MS clinic who were MRI scanned between May 2005 and November 2014. 80 patients (51 female and 29 male) with MS of any type ranging between 16 and 32 years of age (average 26) were included. Images were reviewed by 3 raters and assessed for presence and extent of DDD, as well as cord signal abnormalities. Interrater agreement was assessed using Kendall’s W and Fleiss’ Kappa statistics. Results: Substantial to very good interrater agreement was observed using our novel DDD grading scale. At least some degree of DDD was found in over 91% of patients. The majority scored mild (grade 1, 30-49%) to moderate (grade 2, 39-51%) degenerative changes. Cord signal abnormality was seen in 56-63%. Cord signal abnormality, when present, occurred exclusively at degenerative disc levels in only 10-15%, significantly lower than other distributions ( P < .001 for all pairwise comparisons). Conclusions: MS patients demonstrate unexpected cervical DDD even at a young age. Future study is warranted to investigate the underlying etiology, such as altered biomechanics. Furthermore, cord lesions were found to occur independently of DDD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MRI Markers of Degenerative Disc Disease in Young Patients With Multiple Sclerosis

et al. 2023

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Cervical Spondylosis Severity and Its Correlation with Clinical Parameters and Cervical Lesions in Multiple Sclerosis: A Cross-Sectional MRI Study

Jamalipour Soufi,

Hekmatnia,

Shaygannejad

et al. 2024

Arch Neurosci

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Background: The co-occurrence of multiple sclerosis (MS) and cervical spondylosis (CS) may not only intensify symptoms but also complicate the management of these disorders. Magnetic resonance imaging (MRI) is the preferred modality for detecting spinal cord lesions; however, there is limited evidence assessing myelopathy in concurrent CS and MS. Objectives: This study aims to evaluate the association between CS and its effects on the spinal cord, as well as their impact on enhancing MS cervical lesions. Methods: This cross-sectional study was conducted on 104 MS patients between 2019 and 2021. Data collected included age, gender, duration and phenotype of MS, and the Extended Disability Status Scale (EDSS). Magnetic resonance imaging images were obtained and analyzed for the presence of cervical spondylosis and demyelinated cervical plaques (active/inactive). Multiple sclerosis plaques were evaluated based on their extension, enhancement, and cervical location. Cervical spondylosis was categorized into four grades using the Muhle scale. Additionally, the spinal cord cross-sectional area (SC - CSA) was measured at the C2 - C3 cervical spine level. Results: The severity of cervical spondylosis was associated with older age (P-value < 0.001), longer duration of MS (P-value = 0.04), more severe EDSS scores (P-value = 0.03), and a lower C2 - C3 CS-CSA (P-value < 0.001). However, no significant associations were found with gender (P-value = 0.90), MS plaques activity (P-value = 0.25), or extension (P-value = 0.13). Conclusions: The study findings indicate that the severity of CS is associated with age, MS duration, EDSS, and the C2 - C3 cervical spine cross-sectional area. However, the study did not find evidence supporting a relationship between CS and the extension or activity of MS plaques.

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The relation between cervical and thoracal disc herniations and multiple sclerosis plaques: a retrospective review

Cited by 2 publications

References 21 publications

MRI Markers of Degenerative Disc Disease in Young Patients With Multiple Sclerosis

MRI Markers of Degenerative Disc Disease in Young Patients With Multiple Sclerosis

Cervical Spondylosis Severity and Its Correlation with Clinical Parameters and Cervical Lesions in Multiple Sclerosis: A Cross-Sectional MRI Study

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