The Relation Between ADHD and Cognitive Profiles of Children with NF1

Potvin, Deborah; Hardy, Kristina K.; Walsh, Karin S.

doi:10.1007/s40817-015-0007-3

Cited by 9 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intellectual Pro le. Consistent with previous research [13,17], we found that patients with NF1 ADHD showed the lowest IQ scores of all three groups and di ered signi cantly from patients with NF1 control in all measured areas of intellectual ability (Figure 1). Even though mean scores of all scales of the intelligence test lay within normal limits for the NF1 ADHD group, there seem to exist intellectual challenges in this group, which may not represent a serious disability, but could still crucially in uence long-term adaptive functioning and participation.…”

Section: Data Analysessupporting

confidence: 91%

“…Similar to patients with ADHD-only [15], patients with NF1 ADHD score significantly lower in intelligence tests than healthy (sibling-) controls [14][15][16] and show lower IQ scores than NF1 patients without ADHD (NF1-only) [4,13,14,17]. Also, specific learning disabilities and academic underachievement are associated with ADHD in children, both with and without NF1 [14,16].…”

Section: Introductionmentioning

confidence: 86%

“…ey found that children with NF1 demonstrate an uneven intellectual profile with preserved verbal abilities and reduced nonverbal abilities, working memory, and processing speed. In addition, the combination of NF1 and ADHD led to lower performances in most areas of the intelligence test WISC-IV than ADHD or NF1 exclusively [17].…”

Section: Introductionmentioning

confidence: 94%

“…Striatal dopamine levels could be normalized by dopamine-elevating drugs (e.g., methylphenidate), accompanied by an amelioration of attention performance [11]. First publications on children with NF1 plus ADHD (NF1 ADHD ) provide evidence that, similar as in ADHD-only, pharmaceutical interventions with methylphenidate (MPH) have positive effects on the core symptoms of ADHD [17]. Specifically in patients with NF1 ADHD , there is tentative evidence that MPH might even lead to intellectual improvement [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…So far, few studies directly compared children with NF1 ADHD , NF1-only, and ADHD-only [6,17]. Potvin and colleagues retrospectively compared the intellectual profile of children with NF1 with and without ADHD and children with ADHD-only.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Attention Deficit Predicts Intellectual Functioning in Children with Neurofibromatosis Type 1

Heimgärtner

Granström

Haas-Lude

et al. 2019

International Journal of Pediatrics

View full text Add to dashboard Cite

Aims. Attention deficit hyperactivity disorder (ADHD) is one of the most frequent neurocognitive impairments in neurofibromatosis type 1 (NF1) and a well-known risk factor for intellectual dysfunction in general. Since NF1 is per se associated with intellectual difficulties, this comorbidity may be crucial for the cognitive development of affected patients. In our study, we investigated if attention deficits are associated with intellectual functioning in NF1 and if children with NF1 plus ADHD differ in their intellectual and attention profiles from children affected by NF1-only or ADHD only. Methods. 111 children aged between 6 and 12 years (53 NF1 plus ADHD, 28 NF1-only, 30 ADHD-only) performed the German version of the intelligence test WISC-IV and a continuous performance test (T.O.V.A.) to assess attention functions. Parents completed questionnaires about everyday attention and executive functions (Conners 3®, BRIEF). Results. Children with NF1 plus ADHD showed significantly lower intelligence test scores (full-scale IQ: 89.39 [1.40]) than patients with NF1-only (full-scale IQ: 101.14 [1.98]; p<.001), and intellectual functioning correlated significantly with attention performance in NF1 (p<.001). As compared to NF1-only, attention, and executive functioning were impaired on several dimensions (T.O.V.A., Conners 3® and BRIEF) in NF1 plus ADHD. ADHD-only was associated with significantly higher problem scores regarding hyperactivity/impulsivity and inattention (Conners 3®). NF1-only was associated with inattentiveness when compared to the normative sample of the T.O.V.A. Conclusion. NF1 is associated with variable attention problems. Severe attention deficits appear to be a risk factor for intellectual dysfunction in NF1, more than NF1 without attention deficit. NF1 plus ADHD presents a specific cognitive profile, which differs from that of NF1 and from neurotypical ADHD.

show abstract

Section: Data Analysessupporting

confidence: 91%

Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Attention Deficit Predicts Intellectual Functioning in Children with Neurofibromatosis Type 1

Heimgärtner

Granström

Haas-Lude

et al. 2019

International Journal of Pediatrics

View full text Add to dashboard Cite

show abstract

Factors associated with parental knowledge of neurofibromatosis type 1 (NF1): Parental affected status and genetic counseling

Solem

Primiano

McQuillen

et al. 2020

Journal of Genetic Counseling

View full text Add to dashboard Cite

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an incidence of 1 in 3,500 (Hersh, 2008). NF1 is caused by a pathogenic variant in the NF1 tumor suppressor gene. Common features include café-au-lait spots, inguinal and axillary freckling, Lisch nodules, neurofibromas and scoliosis. Additionally, approximately 40 to 60 percent of NF1 individuals have a learning disability, such as attention-deficit/hyperactivity disorder and difficulties with reading and/or spelling (Hersh, 2008). Less frequently, more severe manifestations such as pseudarthrosis, optic or other low-grade gliomas, and malignant transformation of tumors occur. A de novo pathogenic NF1 variant provides an explanation for approximately half of individuals with NF1, whereas the other half inherited a pathogenic NF1 variant from an affected parent. NF1 is a completely penetrant condition with extreme inter-and intra-familial variability in expression. Relatively few NF1 genotype-phenotype correlated cases are documented. Previous studies have demonstrated that overall NF1 knowledge is deficient among affected individuals and parents of children with NF1 (

show abstract

Assessing neuropsychological phenotypes of pediatric brain tumor survivors

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction Pediatric brain tumor survivors (PBTS) are at risk for both neurocognitive impairments and psychological difficulties, yet these two domains have historically been discretely examined, with assessment of psychosocial outcomes rarely included in studies of cognitive outcomes. Taking a person‐centered approach, the current study aimed to more comprehensively evaluate PBTS late effect profiles, including both neurocognitive and psychological sequelae, and predictors of these profiles. Method PBTS (N = 89) were assessed in a pediatric neuropsychological clinic between May 2009 and May 2018, diagnosed at least 1 year prior, and off‐treatment for at least 3 months (Mage = 6.57 years, SD = 4.53; 46.1% female). Parent‐ and teacher‐report of psychological symptoms, and performance‐based measures of neurocognitive functioning were examined using latent profile analysis. The R3STEP procedure identified predictors of class membership. Results The optimal model identified four classes characterized by: (1) average functioning across all measures (“Average,” n = 47), (2) average psychosocial functioning and impaired neurocognitive functioning (“Cognitive Deficit,” n = 25), (3) elevated social problems and significant neurocognitive impairments (“Social/Cognitive Deficit,” n = 9), and (4) impaired visual planning and problem‐solving and elevated parent‐reported psychosocial problems, but average processing speed, working memory, and teacher‐reported psychosocial outcomes (“Discrepant,” n = 8). Ethnicity, race, radiation treatment, and diagnoses of neurofibromatosis 1, hydrocephalus, and cerebellar mutism syndrome were significant predictors of class membership (ps < 0.05). Conclusion The present study identified distinct phenotypes with unique patterns of relations among neurocognitive and psychological domains. These findings are a vital first step toward identifying those at highest risk for poor outcomes and informing interventions that effectively address interrelated treatment targets for specific groups.

show abstract

The Relation Between ADHD and Cognitive Profiles of Children with NF1

Cited by 9 publications

References 35 publications

Attention Deficit Predicts Intellectual Functioning in Children with Neurofibromatosis Type 1

Attention Deficit Predicts Intellectual Functioning in Children with Neurofibromatosis Type 1

Factors associated with parental knowledge of neurofibromatosis type 1 (NF1): Parental affected status and genetic counseling

Assessing neuropsychological phenotypes of pediatric brain tumor survivors

Contact Info

Product

Resources

About