The Regulatory Role of Matrix Proteins in Mineralization of Bone

Zhu, Wenwu; Robey, Pamela Gehron; Boskey, Adele L.

doi:10.1016/b978-0-12-375098-3.50010-x

Cited by 8 publications

(19 citation statements)

References 562 publications

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“…Although their exact physiological functions are not known, these proteoglycans are assumed to be important for the integrity of most connective tissue matrices. Deletion of the biglycan gene, for example, leads to a signifi cant decrease in the development of trabecular bone, indicating that it is a positive regulator of bone formation [2] . Deletion of the epiphican gene, or the epiphican and biglycan genes together causes shortening of the femur during growth, and early onset osteoarthritis [14] .…”

Section: Collagenmentioning

confidence: 99%

“…For example, α 2 -HSglycoprotein, the human analog of fetuin, when ablated in mice causes ectopic calcifi cation [10] suggesting that the protein is a mineralization inhibitor. The remainder of the exogenous fraction is composed of growth factors and a large variety of other molecules present in trace amounts, which infl uence local bone cell activity [1,2] .…”

Section: Glycosylated P Roteinsmentioning

confidence: 99%

“…Osteonectin, along with thrombospondin-2 (TSP-2) and periostin are members of the class of "matricellular proteins," each of which has a role in bone cell proliferation and differentiation, with some role in regulating mineralization [16] . Tetranectin (which is important for wound healing) [2] , tenascin (which regulates the organization of the extracellular matrix) [17] , and secreted phosphoprotein 24 (which regulates bone morphogenetic protein expression) along with periostin [18] are other glycoproteins found in the bone matrix.…”

Section: Proteoglycansmentioning

confidence: 99%

“…These particular interactions involve cell attachment through transient or stable focal adhesions to extracellular macromolecules, which are mediated by cell surface receptors that subsequently transduce intracellular signals. Bone cells synthesize at least 12 proteins that may mediate cell attachment: members of the small integrin-binding ligand, N-glycosylated protein (SIBLING) family (osteopontin, bone sialoprotein, dentin matrix protein-1, dentin sialophosphoprotein, and matrix extracellular phosphoprotein), type 1 collagen, fi bronectin, maturation [2] . Their post-translational modifi cations also vary, suggesting that these modifi cations may also determine their in situ functions [17,23,24] .…”

Section: Proteoglycansmentioning

confidence: 99%

“…Information on the gene and protein structure and potential function of bone ECM constituents has exploded during the past two decades. This information has been described in great detail in several recent reviews [2,3] , to which the reader is referred for specifi c references; these are too numerous to be listed adequately here. Below is a summary of the composition of bone and the salient features of the classes of bone matrix proteins.…”

Section: Introductionmentioning

confidence: 99%

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The Composition of Bone

Boskey

Robey

2013

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Section: Collagenmentioning

confidence: 99%

Section: Glycosylated P Roteinsmentioning

confidence: 99%

Section: Proteoglycansmentioning

confidence: 99%

Section: Proteoglycansmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Composition of Bone

Boskey

Robey

2013

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Beyond metrics and morphology: the potential of FTIR-ATR and chemometrics to estimate age-at-death in human bone

et al. 2020

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In Forensic Anthropology, the application of traditional methods for estimating the biological profile of human skeletal remains is often hampered by poor preservation and skeletal representativeness, compromising their reliability. Thus, the development of alternative methods to the morphometric analysis of bones to estimate the biological profile of human remains is paramount. The age of an individual can cause changes in bone morphology, mass and size, as well as in its chemical composition. In this sense, the main objective of this research was to evaluate if the contents of bone collagen (Am/P), carbonate type A (API), carbonate type B (BPI), the relation between the carbonate content (types A and B) to type B carbonate (C/C), carbonate-phosphate ratio (C/P) and crystallinity index (CI), spectroscopic indices obtained from relationships between infrared absorption band intensities (FTIR-ATR), can be used as age-at-death predictors. A sample of femora and humeri from the 21 st Century Identified Skeleton Collection (N=80, 44 females and 36 males) was employed. Results show that, with advancing age, women's femora have lower CI values, but BPI and C/P indices increase, and that the deformation and disorder of the crystal lattice are probably affected by the integration of type B carbonate content of the femur. The ratios analysed, especially the CI and the BPI, show potential to estimate age-at-death in human skeletal remains, when sex is already known, thus helping to assess the biological profile when conventional methods cannot be applied.

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The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics

et al. 2019

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The Regulatory Role of Matrix Proteins in Mineralization of Bone

Cited by 8 publications

References 562 publications

The Composition of Bone

The Composition of Bone

Beyond metrics and morphology: the potential of FTIR-ATR and chemometrics to estimate age-at-death in human bone

The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics

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