The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

Serrán, Melisa Gorosito; Vernengo, Facundo Fiocca; Beccaria, Cristian Gabriel; Rodríguez, Eva V. Acosta; Montes, Carolina L.; Gruppi, Adriana

doi:10.1016/j.febslet.2015.08.048

Cited by 50 publications

(36 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, we found that exposure to anti-miR-98 liposomes could reverse the expression of IL-10 in peripheral B cells from patients with atherosclerosis. Since B10 cells are an important immune regulatory cell population in the body, 10,11 the results implicate that the anti-miR-98 liposomes may have the potential in the regulation of the pathogenesis of atherosclerosis. The deficiency of IL-10 production has been recognized in atherosclerosis.…”

Section: Discussionmentioning

confidence: 94%

Cortisol is associated with low frequency of interleukin 10–producing B cells in patients with atherosclerosis

Huo

Chu

Guo

et al. 2017

Cell Biochemistry & Function

View full text Add to dashboard Cite

It is accepted that inflammation plays a critical role in the development of atherosclerosis; the pathogenesis is not clear. B-cell-produced interleukin (IL) 10 is an immune regulatory cytokine that can inhibit immune inflammation. This study tests a hypothesis that a psychological stress hormone, cortisol, suppresses IL-10 expression in peripheral B cells of patients with atherosclerosis. Peripheral blood samples were collected from patients with coronary artery atherosclerosis. B cells were isolated from the blood samples to be analyzed for the expression of IL-10 and micro RNA (miR) 98 by real-time polymerase chain reaction. We observed that the frequency of IL-10 B cell was less in patients with atherosclerosis than healthy controls. The serum cortisol levels were higher in the patients than that in healthy controls. Peripheral B-cell frequency was negatively correlated with the serum cortisol levels. Exposure of B cells to cortisol increased the expression of miR-98 in B cells. Cortisol also inhibited the expression of IL-10 in B cells, in which miR-98 played a critical role. Treating B cells from atherosclerosis patients with anti-miR-98 liposomes reversed the ability of expression of IL-10 in the cells. The expression of IL-10 is suppressed in peripheral B cells, which can be up regulated by anti-miR-98 liposomes.

show abstract

Section: Discussionmentioning

confidence: 94%

Cortisol is associated with low frequency of interleukin 10–producing B cells in patients with atherosclerosis

Huo

Chu

Guo

et al. 2017

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…On one hand, it can be a beneficial reaction to the hosts; such as it can inhibit inflammation17. On the other hand, it can be a hazardous reaction in cancer patients since the immune regulatory cells can suppress tumor specific immunity, such as inhibit tumor specific CD8 + T cells1819.…”

Section: Discussionmentioning

confidence: 99%

Micro RNA-98 interferes with expression interleukin-10 in peripheral B cells of patients with lung cancer

Rong

Qin

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Interleukin (IL)-10-producing B cells (B10 cells) plays an important role in the tumor tolerance. High frequency of peripheral B10 cell was reported in patients with lung cancer recently. Micro RNA (miR) regulates some gene expression. This study test a hypothesis that miR-98 suppresses the expression of IL-10 in B cells of subjects with lung cancer. The results showed that the levels of miR-98 were significantly less in peripheral B cells of patients with lung cancer than that in healthy subjects. IL-10 mRNA levels in peripheral B cells were significantly higher in lung cancer patients as compared with healthy controls. A negative correlation was identified between miR-98 and IL-10 in peripheral B cells. Serum IL-13 was higher in lung cancer patients than that in healthy controls. The levels of IL-13 were also negatively correlated with IL-10 in B cells. Exposure B10 cells to IL-13 in the culture or over expression of miR-98 reduced the expression of IL-10 in B cells. Administration with miR-98-laden liposomes inhibited the lung cancer growth in a mouse model. In conclusion, up regulation of miR-98 inhibits the expression of IL-10 in B cells, which may contribute to inhibit the lung cancer tolerance in the body.

show abstract

“…The Th1/Th17 effector cells are also regulated by Breg cells to down‐regulate the local inflammatory response. In addition, Breg cells can also induce classical Treg and Tr1 cells to promote immune‐regulatory activity …”

Section: Introductionmentioning

confidence: 99%

MiR‐15a/16‐1 deficiency induces IL‐10‐producing CD19⁺ TIM‐1⁺ cells in tumor microenvironment

Jia

Líu

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

IL‐10‐producing B cells (B10) are associated with autoimmune diseases, infection and tumours. MiR‐15a/16 as a tumour‐suppressive gene is down‐regulated in several tumours, such as chronic lymphocytic leukaemia, pituitary adenomas and prostate carcinoma. Here, increased frequency of IL‐10‐producing CD19+ Tim‐1+ cells was seen in both aged miR‐15a/16−/− mice (15‐18 months) with the onset of B cell leukaemia and young knockout mice (8‐12 weeks) transplanted with hepatic cancer cells. CD19+ Tim‐1+ cells down‐regulated the function of effector CD4+CD25low T cells ex vivo dependent on IL‐10 production, and adoptive transfer of CD19+ Tim‐1+ cells promoted tumour growth in mice. IL‐10 production by CD19+ Tim‐1+ cells was involved with the STAT3 activation. Bioinformatics analysis shows that miR‐16 targets the 3′‐untranslating region (3′‐UTR) of STAT3 mRNA. Overexpression of miR‐16 in CD19+ Tim‐1+ cells inhibited STAT3 transcription and its protein expression. Thus, the loss of miR‐15a/16 promoted induction of regulatory CD19+ Tim‐1+ cells in tumour microenvironment. These results confirmed that miR‐15a/16 could be used in tumour therapy due to its inhibition of tumour and regulatory B cells.

show abstract

The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

Cited by 50 publications

References 86 publications

Cortisol is associated with low frequency of interleukin 10–producing B cells in patients with atherosclerosis

Cortisol is associated with low frequency of interleukin 10–producing B cells in patients with atherosclerosis

Micro RNA-98 interferes with expression interleukin-10 in peripheral B cells of patients with lung cancer

MiR‐15a/16‐1 deficiency induces IL‐10‐producing CD19⁺ TIM‐1⁺ cells in tumor microenvironment

Contact Info

Product

Resources

About

The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

Cited by 50 publications

References 86 publications

Cortisol is associated with low frequency of interleukin 10–producing B cells in patients with atherosclerosis

Cortisol is associated with low frequency of interleukin 10–producing B cells in patients with atherosclerosis

Micro RNA-98 interferes with expression interleukin-10 in peripheral B cells of patients with lung cancer

MiR‐15a/16‐1 deficiency induces IL‐10‐producing CD19+ TIM‐1+ cells in tumor microenvironment

Contact Info

Product

Resources

About

MiR‐15a/16‐1 deficiency induces IL‐10‐producing CD19⁺ TIM‐1⁺ cells in tumor microenvironment