The Regulatory Membrane Protein FXYD6: Localization in the Cns and Interaction with the NA+,K+-AtPase

FXYD6 is differentially expressed in non-small cell lung cancer and associates with patient survival.

“…FXYD6 is the only FXYD protein expressed in the inner ear 6 . FXYD proteins can function as regulatory subunits of NKA, interacting with αβ dimers in unique combinations which can reflect tissue-specific expression; these interactions result in altered affinity of NKA for ions being transported 8 . In the hippocampus, cerebellum and SH-SY5Y cells, FXYD6 was found to interact with α1 and α3 NKA subunits 8 .…”

“…FXYD proteins can function as regulatory subunits of NKA, interacting with αβ dimers in unique combinations which can reflect tissue-specific expression; these interactions result in altered affinity of NKA for ions being transported 8 . In the hippocampus, cerebellum and SH-SY5Y cells, FXYD6 was found to interact with α1 and α3 NKA subunits 8 . Patch-clamp experiments in oocytes demonstrated that association of FXYD6 with α1β1 or α3β1 subunits decreased NKA current by reducing the number of α1β1 or α3β1 NKA subunits at the plasma membrane as well as increasing the rate at which α1β1 dimers were turned over.…”