The regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in chronic inflammatory diseases

Liu, Shun; Nong, Weihua; Ji, Lin; Zhuge, Xiuhong; Wei, Huimei; Luo, Min; Zhou, Leguang; Chen, Shenghua; Zhang, Shun; Lei, Xiaocan; Huang, Hua

doi:10.1016/j.exger.2023.112132

Cited by 9 publications

(7 citation statements)

References 208 publications

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“…We conducted a very indirect analysis and showed that patients with concomitant IPF and RD and higher inflammatory parameters tended to have shorter TL. Some studies point at the same direction regarding the involvement of inflammation and short telomeres [45][46][47]. TL has also been reported to have a modifying variable effect in other contexts.…”

Section: Discussionmentioning

confidence: 91%

Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases

Tesolato,

Vicente-Valor,

Jarabo

et al. 2023

Biomedicines

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Interstitial lung diseases (ILDs) constitute a group of more than 200 disorders, with idiopathic pulmonary fibrosis (IPF) being one of the most frequent. Telomere length (TL) shortening causes loss of function of the lung parenchyma. However, little is known about its role as a prognostic factor in ILD patients. With the aim of investigating the role of TL and telomerase activity in the prognosis of patients affected by ILDs, we analysed lung tissue samples from 61 patients. We measured relative TL and telomerase activity by conventional procedures. Both clinical and molecular parameters were associated with overall survival by the Kaplan–Meier method. Patients with IPF had poorer prognosis than patients with other ILDs (p = 0.034). When patients were classified according to TL, those with shortened telomeres reported lower overall survival (p = 0.085); differences reached statistical significance after excluding ILD patients who developed cancer (p = 0.021). In a Cox regression analysis, TL behaved as a risk-modifying variable for death associated with rheumatic disease (RD) co-occurrence (p = 0.029). Also, in patients without cancer, ferritin was significantly increased in cases with RD and IPF co-occurrence (p = 0.032). In relation to telomerase activity, no significant differences were detected. In conclusion, TL in lung tissue emerges as a prognostic factor in ILD patients. Specifically, in cases with RD and IPF co-occurrence, TL can be considered as a risk-modifying variable for death.

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Section: Discussionmentioning

confidence: 91%

Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases

Tesolato,

Vicente-Valor,

Jarabo

et al. 2023

Biomedicines

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“…One proposed mechanism suggests that chronic inflammation directly affects telomerase activity. Elevated cytokine levels might suppress telomerase activity, thereby limiting the enzyme’s ability to counteract telomere shortening and leading to cellular senescence ( Liu et al, 2023 ). This senescence can further enhance inflammation by releasing senescence-associated secretory phenotype (SASP) factors, which induces a feedback loop between inflammation and telomere attrition ( Herranz and Gil, 2018 ).…”

Section: Telomere Biology: the Basics And Beyondmentioning

confidence: 99%

Unlocking longevity: the role of telomeres and its targeting interventions

Schellnegger,

Hofmann,

Carnieletto

et al. 2024

Front. Aging

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Average life expectancy has been steadily increasing in developed countries worldwide. These demographic changes are associated with an ever-growing social and economic strain to healthcare systems as well as society. The aging process typically manifests as a decline in physiological and cognitive functions, accompanied by a rise in chronic diseases. Consequently, strategies that both mitigate age-related diseases and promote healthy aging are urgently needed. Telomere attrition, characterized by the shortening of telomeres with each cell division, paradoxically serves as both a protective mechanism and a contributor to tissue degeneration and age-related ailments. Based on the essential role of telomere biology in aging, research efforts aim to develop approaches designed to counteract telomere attrition, aiming to delay or reduce age-related diseases. In this review, telomere biology and its role in aging and age-related diseases is summarized along with recent approaches to interfere with telomere shortening aiming at well- and healthy-aging as well as longevity. As aging research enters a new era, this review emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors, while also exploring the effects of antioxidative and anti-inflammatory agents, along with indirectly related approaches like statins.

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“…Inflammatory stimuli can accelerate telomere attrition and result in telomere dysfunction and shortening. Conversely, TeS can contribute to low-grade inflammation [78].…”

Section: Potential Benefits Of Telomere Manipulation In Atheroscleros...mentioning

confidence: 99%

How a Plant-Based Diet (PBD) Reduces In-Stent Restenosis (ISR) and Stent Thrombosis (ST)

2024

Cardio Open

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Despite the advances in stent design, coating drugs, polymers, the use of intravascular imaging, special devices (such as intravascular lithotripsy, ultra-high-pressure non-compliant balloons, and drug-coated balloons), and improved operator skills and techniques, the problem of in-stent restenosis (ISR) and stent thrombosis (ST) remains a challenge for interventional cardiologists. Atherosclerotic lesions, ISR, and ST, are systemic metabolic chronic inflammatory illnesses with a local manifestation in the coronary vessels. Therefore, we propose managing these systemic illnesses systemically through plant-based diet (PBD) intervention. We explain how PBD intervention can help mitigate atherosclerosis, ISR, and ST. Thus, PBD intervention can overcome biological and epigenetic problems in managing ISR and ST similarly to reversing atherosclerosis. Our team is pioneering the implementation of PBD for cardiology patients who have undergone coronary intervention. So far, the results have been very promising. We hope that in the future, many research studies will be performed to investigate further the role of PBD in decreasing the incidence of ISR and ST

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The regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in chronic inflammatory diseases

Cited by 9 publications

References 208 publications

Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases

Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases

Unlocking longevity: the role of telomeres and its targeting interventions

How a Plant-Based Diet (PBD) Reduces In-Stent Restenosis (ISR) and Stent Thrombosis (ST)

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