The regulation role of interferon regulatory factor-1 gene and clinical relevance

Dou, Liping; Liang, Huifang; Geller, David A.; Chen, Yifa; Chen, Xiaoping

doi:10.1016/j.humimm.2014.09.015

Cited by 49 publications

(47 citation statements)

References 67 publications

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“…It is well known that in lymphocytes IRF-1 transcription factor via STAT-1 is involved in the regulation of IFN-γ production, as well as in the synthesis of the lytic proteins 27. We show for the first time decreased mRNA level of IRF-1 in PBMC of patients with MM compared with HCs that is, in this study, followed by decreased STAT-1 level, as well as impaired perforin and IFN-γ expression in PBMC of these patients.…”

Section: Discussionmentioning

confidence: 99%

Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma

et al. 2015

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“…IRF-1 is expressed at low levels in quiescent cells and its expression is increased by various stimuli, such as types I and II IFN, LPS, IL-1, IL-6, TNF-α, and viral infection [15,16] . IRF-1 is either a transcriptional activator or a repressor of target genes that plays key roles in anti-infection immune responses, the regulation of oncogenes, cell proliferation, proinflammatory gene expression, and the development of the immune system [16,17] . Moreover, IRF-1 gene induction in the renal tubules by reactive oxygen species was shown to be an early event that exacerbated injury and promoted inflammation in murine ischemia/reperfusion injury [18] .…”

Section: Introductionmentioning

confidence: 99%

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB

Yan¹,

Meurs²,

Popa³

et al. 2017

J Innate Immun

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Sepsis is a severe systemic inflammatory response to infection. Endothelial activation and dysfunction play a critical role in the pathophysiology of sepsis and represent an important therapeutic target to reduce sepsis mortality. Interferon regulatory factor 1 (IRF-1) was recently identified as a downstream target of TNF-α-mediated signal transduction in endothelial cells. The aim of this study was to explore the importance of IRF-1 as a regulator of lipopolysaccharide (LPS)-induced endothelial proinflammatory activation. We found that renal IRF-1 was upregulated by LPS in vivo as well as in LPS-stimulated endothelial cells in vitro. Furthermore, we identified intracellular retinoic acid inducible gene-I (RIG-I) as a regulator of LPS-mediated IRF-1 induction. IRF-1 depletion specifically resulted in diminished induction of VCAM-1 in response to LPS, but not of E-selectin or ICAM-1, which was independent of NFκB signaling. When both IRF-1 and the RIG-I adapter protein mitochondrial antiviral signaling (MAVS) were absent, VCAM-1 induction was not additionally inhibited, suggesting that MAVS and IRF-1 reside in the same signaling pathway. Surprisingly, E-selectin and IL-6 induction were no longer inhibited by MAVS knockdown when IRF-1 was also absent, revealing a redundant endothelial activation pathway. In summary, we report an IRF-1-mediated proinflammatory signaling pathway that specifically regulates LPS-mediated VCAM-1 expression, independent of NFκB.

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“…16 Our previous study also showed that IRF1 served as a tumor suppressor in the regulation of cholangiocarcinoma cell proliferation, cell cycle, migration, and invasion 10 Meanwhile, low IRF expression was observed in cholangiocarcinoma tissue and cell samples, and associated with clinical progression and an unfavorable prognosis in cholangiocarcinoma cases. 16 Our previous study also showed that IRF1 served as a tumor suppressor in the regulation of cholangiocarcinoma cell proliferation, cell cycle, migration, and invasion 10 Meanwhile, low IRF expression was observed in cholangiocarcinoma tissue and cell samples, and associated with clinical progression and an unfavorable prognosis in cholangiocarcinoma cases.…”

Section: Discussionmentioning

confidence: 93%

miR‐383 promotes cholangiocarcinoma cell proliferation, migration, and invasion through targeting IRF1

Wan

Chi

et al. 2018

J of Cellular Biochemistry

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Interferon regulatory factor 1 (IRF1) has been found to serve as a tumor suppressor in cholangiocarcinoma, and enabled prediction of clinical progression and prognosis in our previous study. The objective of the current study is to screen and identify valuable microRNAs (miR), which target IRF1 to regulate cholangiocarcinoma cell proliferation, migration, and invasion. High expression of miR-383 was observed in cholangiocarcinoma tissues and cells. Meanwhile, we found the predicted binding site of miR-383 on the IRF1 3'-untranslated region (3'-UTR) according to the miR target database. The miR-383 expression was negatively related to IRF1 messeneger RNA (mRNA) and protein expression in cholangiocarcinoma tissue samples, and miR-383 negatively regulated IRF1 mRNA and protein expression in cholangiocarcinoma cells. Subsequently, we conducted a luciferase reporter assay to prove the predicted binding site miR-383 on IRF1 3'-UTR. Moreover, the results of the rescue study suggested that IRF1 was a functional target of miR-383 involved in regulating cholangiocarcinoma cell proliferation, migration, and invasion. Finally, we evaluated the clinical and prognostic significance of miR-383 in cholangiocarcinoma cases, and found that high expression of miR-383 was correlated with advanced tumor stage, large tumor size, present vascular invasion, and metastasis, and acted as an unfavorable independent prognostic factor. In conclusion, miR-383 serves as a tumor-suppressive miR to regulate cholangiocarcinoma cell proliferation, migration, and invasion via directly targeting IRF1.

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The regulation role of interferon regulatory factor-1 gene and clinical relevance

Cited by 49 publications

References 67 publications

Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma

Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB

miR‐383 promotes cholangiocarcinoma cell proliferation, migration, and invasion through targeting IRF1

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The regulation role of interferon regulatory factor-1 gene and clinical relevance

Cited by 49 publications

References 67 publications

Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma

Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NF&#x03BA;B

miR‐383 promotes cholangiocarcinoma cell proliferation, migration, and invasion through targeting IRF1

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Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB