The regulation of social recognition, social communication and aggression: Vasopressin in the social behavior neural network

Albers, H. Elliott

doi:10.1016/j.yhbeh.2011.10.007

Cited by 252 publications

(208 citation statements)

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“…This portrayal is accurate, but only to a certain extent. VP acts via V1aRs in the AH to promote aggression in male Syrian hamsters (Mesocricetus auratus) that have been socially isolated and trained as fighters, and in male prairie voles after mating (i.e., mating-induced aggression, which is associated with pair bonding) (9). Aggression in these contexts is associated with increased Fos expression in an intrinsic population of VP neurons in the AH, and also with experience-dependent plasticity in V1aR densities (9).…”

Section: Pvn Ot Neurons Promote Pair Bonding and Intrapair Affiliationmentioning

confidence: 99%

“…VP acts via V1aRs in the AH to promote aggression in male Syrian hamsters (Mesocricetus auratus) that have been socially isolated and trained as fighters, and in male prairie voles after mating (i.e., mating-induced aggression, which is associated with pair bonding) (9). Aggression in these contexts is associated with increased Fos expression in an intrinsic population of VP neurons in the AH, and also with experience-dependent plasticity in V1aR densities (9). No effects of AH VP manipulations are observed in male hamsters that are socially housed (9), however, and in fact, intra-AH infusions of a V1aR antagonist increase aggression in female hamsters, opposite of the effects in males (36).…”

Section: Pvn Ot Neurons Promote Pair Bonding and Intrapair Affiliationmentioning

confidence: 99%

“…For instance, 20 different forebrain areas produce OT in the mustached bat (Pteronotus parnellii) (7), and sites of VP production are comparably numerous (8). Importantly, even the smallest of these populations, such as the accessory VP populations of the anterior hypothalamus (AH), may exert profound effects on behavior (9).…”

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confidence: 99%

“…In fact, very few experiments have actually demonstrated the roles of specific VP-OT cell groups in behavior. In mammals, PVN OT production and intra-PVN OT signaling promote maternal care and modulate maternal aggression (22,23), and accessory VP neurons of the AH promote male aggression in an experiencedependent manner (9). The behavioral roles of other cell groups have not been determined.…”

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confidence: 99%

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Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

Kelly

Goodson

2014

Proc. Natl. Acad. Sci. U.S.A.

100

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Antagonism of oxytocin (OT) receptors (OTRs) impairs the formation of pair bonds in prairie voles (Microtus ochrogaster) and zebra finches (Taenioypygia guttata), and also reduces the preference for the larger of two groups ("gregariousness") in finches. These effects tend to be stronger in females. The contributions of specific peptide cell groups to these processes remain unknown, however. This issue is complicated by the fact that OTRs in finches and voles bind not only forms of OT, but also vasopressin (VP), and >10 cell groups produce each peptide in any given species. Using RNA interference, we found that knockdown of VP and OT production in the paraventricular nucleus of the hypothalamus exerts diverse behavioral effects in zebra finches, most of which are sexually differentiated. Our data show that knockdown of VP production significantly reduces gregariousness in both sexes and exerts sexspecific effects on aggression directed toward opposite-sex birds (increases in males; decreases in females), whereas OT knockdown produces female-specific deficits in gregariousness, pair bonding, and nest cup ownership; reduces side-by-side perching in both sexes; modulates stress coping; and induces hyperphagia in males. These findings demonstrate that paraventricular neurons are major contributors to the effects of VP-OT peptides on pair bonding and gregariousness; reveal previously unknown effects of sex-specific peptide on opposite-sex aggression; and demonstrate a surprising lack of effects on same-sex aggression. Finally, the observed effects of OT knockdown on feeding and stress coping parallel findings in mammals, suggesting that OT modulation of these processes is evolutionarily conserved across the amniote vertebrate classes.vasotocin | mesotocin | social behavior N umerous pharmacological studies, such as those using sitespecific infusions of agonists and antagonists, have demonstrated that the vasopressin (VP)-oxytocin (OT) nonapeptides modulate diverse behaviors, including parental care, aggression, communication, sexual behavior, affiliation, anxiety, pair bonding, and stress response (1-3). Such manipulations do not allow us to infer the functions of specific VP-OT neuronal populations, however, because the peptides are produced in numerous cell groups, at least some of which give rise to widespread and longdistance paracrine modulation, including release from axons, dendrites, and soma (4-6). The various VP-OT cell groups also exhibit overlapping axonal projections, and thus any given brain area potentially receives peptides from many different sources (4). Indeed, there is an extremely high potential for overlapping modulation from the various cell groups, because numerous brain areas produce OT and VP in any given species. For instance, 20 different forebrain areas produce OT in the mustached bat (Pteronotus parnellii) (7), and sites of VP production are comparably numerous (8). Importantly, even the smallest of these populations, such as the accessory VP populations of the anterior hypothalamus (AH)...

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Section: Pvn Ot Neurons Promote Pair Bonding and Intrapair Affiliationmentioning

confidence: 99%

Section: Pvn Ot Neurons Promote Pair Bonding and Intrapair Affiliationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

Kelly

Goodson

2014

Proc. Natl. Acad. Sci. U.S.A.

100

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“…Numerous disciplines have contributed to the copious studies indicating a role for oxytocin and vasopressin systems in adult social behavior (for detailed reviews, see Carter et al, 2008;Donaldson and Young, 2008;Insel, 2010;Gordon et al, 2011;Kavaliers and Choleris, 2011;MeyerLindenberg et al, 2011;Young et al, 2011;Albers, 2012;Bosch and Neumann, 2012;Ebstein et al, 2012;Wacker and Ludwig, 2012;Zink and Meyer-Lindenberg, 2012;Goodson, 2013). We know that manipulating these systems in adulthood alters brain and behavior, so why should we consider oxytocin and vasopressin in the developmental emergence of brain and behavior?…”

Section: Introductionmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

153

146

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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Beyond Social Cognition

2016

Social Cognition in Middle Childhood and Adolescence

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The regulation of social recognition, social communication and aggression: Vasopressin in the social behavior neural network

Cited by 252 publications

References 142 publications

Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

Developmental Perspectives on Oxytocin and Vasopressin

Beyond Social Cognition

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