The Regulation of Receptors, Ion Channels, and G Proteins in Congestive Heart Failure

Gopalakrishnan, Murali; Triggle, David J.

doi:10.1111/j.1527-3466.1990.tb00397.x

Cited by 17 publications

(2 citation statements)

References 225 publications

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“…Another consistent theme that was encouraged was to consistently keep up with the literature in the field, and when appropriate, find opportunities to review recent developments and share one's own perspectives. Although this was initially challenging as a graduate student, such exercises proved very useful in analyzing key observations and drawing overarching conclusions and lead to an important collection of publications [30,31]. One such review was submitted to Drug Development Research, edited by Mike Williams, who at the time was heading up Neuroscience Discovery at Abbott, where I subsequently became employed after my postdoctoral work.…”

Section: Ion Channels As Regulated Speciesmentioning

confidence: 97%

On Becoming a Pharmacologist: Channeling David Triggle

Rampe

Gopalakrishnan

2015

Biochemical Pharmacology

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Section: Ion Channels As Regulated Speciesmentioning

confidence: 97%

On Becoming a Pharmacologist: Channeling David Triggle

Rampe

Gopalakrishnan

2015

Biochemical Pharmacology

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“…Regulation of ionic currents by external physicochemical agents like drugs (Ferrante and Triggle, 1990), disease states (Gopalakrishnan and Triggle, 1990), learning and memory (Alkon, 1990;Scholz and Byme, 1987), and aging (Navaratnam and Khatter, 1990) plays an important role in the regulation of cellular excitability. The Drosophila larval muscles exhibit at least two voltage-gated and two Ca*+-activated K+-currents ( Wu and Haugland, 1985;Singh and Wu, 1989;Gho and Mallart, 1986).…”

Section: Introductionmentioning

confidence: 99%

Developmental temperature selectively regulates a voltage‐activated potassium current in Drosophila

Chopra

Singh

1994

J. Neurobiol.

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Ionic currents are regulated by many conditions including disease states, aging, learning and memory, and chronic drug treatment. Here we describe a novel phenomenon of regulation of ionic currents by developmental temperature. Raising Drosophila larvae at 28 degrees C instead of 18 degrees C increased one of the two voltage-activated K(+)-currents, the delayed sustained IK, in their muscles by up to 3.5-fold, with little effect on the early transient current, IA. Consistent with this increase in IK, the amplitude and the duration of the action potentials were reduced. The major increase in IK occurred between a rather abrupt interval from 25 degrees to 28 degrees C. The activation curve of the increased current was shifted towards hyperpolarizing potentials. There was no change in activation kinetics. This phenomenon has mechanistic implications for activity-dependent neuronal plasticity, expression of ion channels in cultured cells and heterologous systems, phototransduction, and behavior. The specificity of the regulation suggests a discrete mechanism geared to affect excitability such that it can respond to altered external stimuli such as temperature.

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Modulation of the dihydropyridine‐sensitive calcium channels in Drosophila by a phospholipase C‐mediated pathway

Singh

1997

J. Neurobiol.

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Disruption of phospholipase C‐β (PLC) by the norpA mutations of Drosophila renders flies blind by affecting the light‐evoked photoreceptor potential. We report here that the norpA‐coded PLC modulates the 1,4‐dihydropyridine (DHP)‐sensitive Ca2+ channels in larval muscles. The DHP‐sensitive current was reduced in the norpA mutants. Application of 1 μM phorbol 12‐myristate 13‐acetate (TPA) and 1 μM phorbol 12,13‐didecanoate (PDD), activators of protein kinase C (PKC), rescued the current in the mutant fibers without significantly affecting the normal current. 4α‐phorbol 12,13‐didecanoate (4αPDD), an inactive analog of PDD, did not affect either the normal or the mutant current. One micromolar bisindolylmaleimide (BIM), an inhibitor of PKC, reduced the current in the normal fibers without affecting the mutant current. 300 μM sn‐1,2‐dioctanoyl‐glycerol (DOG), an analog of diacylglycerol (DAG), increased the current in the mutant fibers. These experiments suggest that the DHP‐sensitive Ca2+ channels in Drosophila may be modulated by the PLC‐DAG‐PKC pathway, and that the same PLC isozyme which is involved in phototransduction in the adult flies may also modulate muscle Ca2+ channels in the larval stage of development. © 1997 John Wiley & Sons, Inc. J Neurobiol 33: 265–275, 1997

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The Regulation of Receptors, Ion Channels, and G Proteins in Congestive Heart Failure

Cited by 17 publications

References 225 publications

On Becoming a Pharmacologist: Channeling David Triggle

On Becoming a Pharmacologist: Channeling David Triggle

Developmental temperature selectively regulates a voltage‐activated potassium current in Drosophila

Modulation of the dihydropyridine‐sensitive calcium channels in Drosophila by a phospholipase C‐mediated pathway

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