1992
DOI: 10.1139/y92-273
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The regulation of pH in the central nervous system

Abstract: The pHi regulation from intracellular acidosis in the central nervous system appears to be mediated by mechanisms driven by the large inwardly directed Na+ gradient. The involvement of these mechanisms in pHi regulation of neurones and glial cells has been investigated in the leech central nervous system using ion-selective microelectrodes. For recovery from acidification, there appear to be three separate mechanisms: Na+/H+ exchange, Na(+)-dependent Cl-/HCO3- exchange, and Na+-HCO3- cotransport. All three mec… Show more

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Cited by 13 publications
(4 citation statements)
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References 33 publications
(19 reference statements)
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“…Changes in extracellular pH may alter intracellular pH (Schlue & Dorner, 1992; Deitmer & Rose, 1996). To determine whether changes in intracellular pH are involved in the proton‐induced modulation of the csNSC currents, we have studied the effect of quinine, an agent known to cause intracellular alkalinization (Dixon et al .…”
Section: Resultsmentioning
confidence: 99%
“…Changes in extracellular pH may alter intracellular pH (Schlue & Dorner, 1992; Deitmer & Rose, 1996). To determine whether changes in intracellular pH are involved in the proton‐induced modulation of the csNSC currents, we have studied the effect of quinine, an agent known to cause intracellular alkalinization (Dixon et al .…”
Section: Resultsmentioning
confidence: 99%
“…Whether, in the normal presence of extracellular CO 2 and HCO 3 − , a Cl − extrusion is accomplished also by a Na + ‐dependent Cl–HCO 3 [(Na–HCO 3 )–(H–Cl)] exchanger ( Moody 1981, Moser 1985, Schlue & Dörner 1992) is as yet unclear. It might be surmised, though, that as primary pH adjuster a Na + ‐dependent Cl–HCO 3 exchanger would not carry Cl − in bulk quantities.…”
Section: Discussionmentioning
confidence: 99%
“…Included, because integral to the topic, are a brief overview of pH regulation in mammalian astrocytes and a consideration of the mechanisms by which K ϩ , glutamate, and ammonium induce pH changes. Several reviews offer the reader a broader perspective on the effects of pH on cell metabolism (Busa and Nuccitelli, 1984) and excitable membranes (Moody, 1984), and on the regulation and modulation of pH in the brain (Chesler, 1990;Chesler and Kaila, 1992;Schlue and Dörner, 1992) and specifically in glia (Deitmer and Rose, 1996).…”
Section: Introductionmentioning
confidence: 99%