The regulation of osmotic and ionic balance in fish reproduction and in the early stages of ontogeny

Dolomatov, Sergey; Zukow, Walery; Novikov, Nikolai; Muszkieta, Radosław; Bułatowicz, Irena; Dzierżanowski, Maciej; Kaźmierczak, Urszula; Strojek, Katarzyna

doi:10.1134/s1063074012050057

Cited by 11 publications

(4 citation statements)

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“…A mutant of this kind would react biologically as an antimorph, causing disruption to proteolytic activity in a dose-response manner [ 31 , 32 ]. The greatest amounts of fsh production and release correlate to the vitellogenesis stage of the salmon’s annual breeding process [ 12 ]. The membrane receptors for fsh are located on the granulosa and theca cells of the follicle.…”

Section: Discussionmentioning

confidence: 99%

“…All α subunits are identical within a single species of fish; however, the different β subunits communicate the hormone’s physiological specialness [ 11 ]. In salmon, the maximal levels of fsh formation and release correspond to the yolk formation stage (vitellogenesis) in the annual breeding cycle, whereas lh generation peaks amid egg maturity and spawning [ 12 ]. Salmonid fish have high fsh levels during spermatogenesis and optimum lh levels in the spawning season according to [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Gene Editing of the Follicle-Stimulating Hormone Gene to Sterilize Channel Catfish, Ictalurus punctatus, Using a Modified Transcription Activator-like Effector Nuclease Technology with Electroporation

Qin

et al. 2023

Biology

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Follicle-stimulating hormone (fsh) plays an important role in sexual maturation in catfish. Knocking out the fsh gene in the fish zygote should suppress the reproduction of channel catfish (Ictalurus punctatus). In this study, transcription activator-like effector nuclease (TALEN) plasmids targeting the fsh gene were electroporated into fertilized eggs with the standard double electroporation technique. Targeted fsh cleavage efficiency was 63.2% in P1fsh-knockout catfish. Ten of fifteen (66.7%) control pairs spawned, and their eggs had 32.3–74.3% average hatch rates in 2016 and 2017. Without hormone therapy, the spawning rates of P1 mutants ranged from 33.3 to 40.0%, with an average egg hatching rate of 0.75%. After confirmation of the low fertility of P1 mutants in 2016, human chorionic gonadotropin (HCG) hormone therapy improved the spawning rates by 80% for female mutants and 88.9% for male mutants, and the mean hatch rate was 35.0% for F1 embryos, similar to that of the controls (p > 0.05). Polymerase chain reaction (PCR) identification showed no potential TALEN plasmid integration into the P1 channel catfish genome. Neither the P1 nor the F1 mutant fish showed any noticeable changes in in body weight, survival rate, and hatching rate when the reproductive gene was knocked out. F1 families had a mean inheritance rate of 50.3%. The results brought us one step closer to allowing implementation of certain genetic techniques to aquaculture and fisheries management, while essentially eliminating the potential environment risk posed by transgenic, hybrid, and exotic fish as well as domestic fish.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gene Editing of the Follicle-Stimulating Hormone Gene to Sterilize Channel Catfish, Ictalurus punctatus, Using a Modified Transcription Activator-like Effector Nuclease Technology with Electroporation

Qin

et al. 2023

Biology

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“…In the process of phylogenesis, the primary production of mineralocorticoids in amniotes occurred relatively recently in connection with the accommodation of vertebrates on land. While in the lower vertebrates (anamniums), the function of mineral corticoids was performed by cortisol (Dolomatov et al, 2012). This is probably why we can observe interferent effects of glucocorticoids and aldosterone on sodium reabsorption processes in the distal part of the human nephron (Feraille & Dizin, 2016;Nehme & Zibara, 2017).…”

Section: Mineralocorticoidsmentioning

confidence: 99%

Ecological aspects of molecular mechanisms of epigenetic rearrangement of humoral systems of the renal function regulation

Dolomatov

Sataieva

Żukow

et al. 2018

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Epigenetic transformation of chromatin is able to be induced by environmental factors and changes in the parameters of the state of metabolic processes in the body. Among them, the most common known factors are hypoxia (ischemia of the organ), hyperglycemia, heavy metals, endocrinopathies, infectious diseases. The results of the review conclude that epigenetic mechanisms pay the very important contribution to the restructuring of humoral systems of renal regulation during renal failure sufficiently contributing to a progressive reduction of nephrons and directly preconditioning the unfavorable progress of the disease. In considering this potential etiologic factor, one must take into account several common triggers changing the epigenetic transformation of intrarenal synthesis and metabolism of physiologically active substances. Primary it is the formation of atypical foci of their products, which is most evident in the processes of restructuring of the RAS and nitric oxide systems. Secondary the renal coordinating humoral factors increasingly lose the control of regulation of homeostasis and switch on the pathophysiological way of progressive renal failure. Next are the epigenetic changes of proteins genes that perform key functions in the synthesis and metabolism of humoral factors in the regulation of renal functions. Uncontrolled synthesis of these peptides leads to a triggered enhancement of the process, again, involving epigenetic chromatin rearrangement. The indicated regularity can be traced to unrestricted activation of RAAS and the renal system of TGF-beta. Other contributing factors occur as a result of unrestricted activation of RAAS and the TGF-beta system. On this background, there is a steady decline in the regulatory capabilities of the opposition control vector represented by the nitrogen oxide system, primarily by the constitutive isoforms eNOS and nNOS. The research of epigenetic processes during various nephropathies does not only enlightens theoretical basis for the pathogenesis of renal failure but also opens promising approaches for the development of new pharmacological corrects of renal function. kidneys, renal failure, epigenetics, renin-angiotensin-aldosterone system, transforming growth factor beta, nitric oxide.

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“…In contrast, other factors such as composition and physico-chemical parameters of the water have received far less attention (Brooks et al, 1997;Bobe and Labbe, 2010). Ionic composition of the water is however likely to influence the final steps of oogenesis (i.e., final oocyte maturation -FOM) given the importance of water exchange during this critical period (Dolomatov, 2012). Among mineral elements, chloride, sodium and potassium are of specific interest because (i) they are the most abundant electrolytes in the body of living organisms and (ii) they serve a vital function in controlling osmotic pressure and acid-base equilibrium (Lall, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of a low water concentration in chloride, sodium and potassium on oocyte maturation, oocyte hydration, ovulation and egg quality in rainbow trout

Segret

Cardona

Skiba‐Cassy

et al. 2021

Preprint

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Water salinity is an important environmental factor known to have detrimental effects on salmonid reproduction, mostly when migrating female broodfish are held in sea water. In contrast, data obtained in freshwater are scarce and the impact of low water salinity during reproduction in freshwater is currently unknown. For this reason, and because ion and water fluxes are critical for the final steps of the female gamete formation, including oocyte hydration and ovulation, the aim of the present study was to investigate the impact of low salinity water on final oocyte maturation, ovulation and, ultimately, on egg quality, using rainbow trout as a physiological model and relevant aquaculture species. Fish from the same commercial strain were raised throughout their lifecycle either in a site characterized by low concentrations of Na+, K+, and Cl- ions in the water or in a closely located control site exhibiting standard salinity levels. Egg quality and duration of final oocyte maturation were investigated using innovative phenotyping tools such as automatic assessment of egg viability using the VisEgg system and non-invasive echograph-based monitoring of final oocyte maturation duration, respectively. Oocyte hydration during final oocyte maturation and after ovulation was also investigated. Finally, molecular phenotyping was performed using real-time PCR-based monitoring of several key players of final oocyte maturation and ovulation associated with ion and water transport, inflammation, proteolytic activity, and coagulation. Oocyte hydration and gene expression data were analyzed in the light of the duration of final oocyte maturation. Here we show that low water salinity negatively influences final oocyte maturation, ovulation and, ultimately, egg quality. Low water salinity triggers delayed ovulation and lower oocyte viability. When investigating the impact of low water salinity on final oocyte maturation duration, individuals presenting the most severe phenotypes exhibited impaired oocyte hydration and abnormally reduced gene expression levels of several key players of the ovulatory process. While the under expression of water (e.g., aquaporins) and ion (e.g., solute carriers) transporters is consistent with impaired oocyte hydration, our observations also indicate that the entire ovulatory gene expression program is disrupted. Our results raise the question of the mechanisms underlying the negative influence of low salinity water on the dynamics of the preovulatory phase, on the control of the oocyte homeostasis, including hydration, and on the overall success of the maturation-ovulation process.

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The regulation of osmotic and ionic balance in fish reproduction and in the early stages of ontogeny

Cited by 11 publications

References 68 publications

Gene Editing of the Follicle-Stimulating Hormone Gene to Sterilize Channel Catfish, Ictalurus punctatus, Using a Modified Transcription Activator-like Effector Nuclease Technology with Electroporation

Gene Editing of the Follicle-Stimulating Hormone Gene to Sterilize Channel Catfish, Ictalurus punctatus, Using a Modified Transcription Activator-like Effector Nuclease Technology with Electroporation

Ecological aspects of molecular mechanisms of epigenetic rearrangement of humoral systems of the renal function regulation

Effect of a low water concentration in chloride, sodium and potassium on oocyte maturation, oocyte hydration, ovulation and egg quality in rainbow trout

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