The Regulation of Neutrophil Extracellular Trap–induced Tissue Damage by Human CD177

Yoneyama, Tomohisa; Maeda, Akira; Kogata, Shuhei; Toyama, Chiyoshi; Lo, Pei‐Chi; Masahata, Kazunori; Kamiyama, Masafumi; Haneda, Tomoko; Okamatu, Chizu; Eguchi, Hiroshi; Tazuke, Yuko; Ueno, Takayoshi; Okuyama, Hiroomi; Miyagawa, Shuji

doi:10.1097/txd.0000000000001175

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…However, the regulation of these macrophages and others is also a major challenge for the future. A single CD47 ( 89 ) molecule is not sufficient, and comprehensive regulation including HLA classIb ( 90 , 91 ), CD200 ( 92 ), TIGIT ( 93 ), CD177 ( 94 ), etc. needs to be carefully examined.…”

Section: Ibmir and Irimentioning

confidence: 99%

Aspects of the Complement System in New Era of Xenotransplantation

et al. 2022

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After producing triple (Gal, H-D and Sda)-KO pigs, hyperacute rejection appeared to no longer be a problem. However, the origin of xeno-rejection continues to be a controversial topic, including small amounts of antibodies and subsequent activation of the graft endothelium, the complement recognition system and the coagulation systems. The complement is activated via the classical pathway by non-Gal/H-D/Sda antigens and by ischemia-reperfusion injury (IRI), via the alternative pathway, especially on islets, and via the lectin pathway. The complement system therefore is still an important recognition and effector mechanism in xeno-rejection. All complement regulatory proteins (CRPs) regulate complement activation in different manners. Therefore, to effectively protect xenografts against xeno-rejection, it would appear reasonable to employ not only one but several CRPs including anti-complement drugs. The further assessment of antigens continues to be an important issue in the area of clinical xenotransplantation. The above conclusions suggest that the expression of sufficient levels of human CRPs on Triple-KO grafts is necessary. Moreover, multilateral inhibition on local complement activation in the graft, together with the control of signals between macrophages and lymphocytes is required.

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Section: Ibmir and Irimentioning

confidence: 99%

Aspects of the Complement System in New Era of Xenotransplantation

et al. 2022

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Single-Cell Transcriptomic Profiles of Lung Pre-Metastatic Niche Reveal Neutrophil and Lymphatic Endothelial Cell Roles in Breast Cancer

Huang

Chang

et al. 2022

Cancers

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The establishment of a pre-metastatic niche (PMN) is critical for cancer metastasis. However, it remains unclear as to which phenotypes induce changes in the PMN. Single-cell transcriptomic profiling of all cells of the lung in cancer-bearing MMTV-PyVT mice revealed an increased infiltration of N2-type neutrophils and classical monocytes associated with chronic inflammation; notably, lung neutrophils isolated from mice with primary cancer exhibited similar N2-type phenotypes and expressed high levels of inflammatory and angiogenic factors. We also discovered a new cluster of Ki67-upregulated lymphatic endothelial cells (ECs) that activated several cell division-related pathways. Receptor–ligand interactions within the lung potentially mediated PMN formation; these were exemplified by the cross talk of lymphatic EC–N2-type neutrophil via S100A6. In vitro study revealed S100A6 impaired EC tight junction and increased the transendothelial migration of neutrophils. Our results highlight the molecular mechanisms that shape lung PMN and inspire preventive strategies for lung metastasis in breast cancer.

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The Regulation of Neutrophil Extracellular Trap–induced Tissue Damage by Human CD177

Abstract: Supplemental Digital Content is available in the text.

Cited by 2 publications

References 38 publications

Aspects of the Complement System in New Era of Xenotransplantation

Aspects of the Complement System in New Era of Xenotransplantation

Single-Cell Transcriptomic Profiles of Lung Pre-Metastatic Niche Reveal Neutrophil and Lymphatic Endothelial Cell Roles in Breast Cancer

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