The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation

Collu-Marchese, Melania; Shuen, Michael; Pauly, Marion; Saleem, Ayesha; Hood, David A.

doi:10.1042/bsr20150073

Cited by 34 publications

(29 citation statements)

References 26 publications

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“…, Collu‐Marchese et al . ), appears also as a plausible molecular explanation for the beneficial adaptations observed in LHTLH vs. LHTL vs. LLTL.…”

Section: Discussionmentioning

confidence: 87%

“…exercise mode, frequency and duration) between studies might be responsible for these discrepant findings. In summary, the increase in PGC-1a and TFAM measured after intervention in LHTLH, for which mRNA expression predicts protein levels quite well (Handschin et al 2003, Collu-Marchese et al 2015, appears also as a plausible molecular explanation for the beneficial adaptations observed in LHTLH vs. LHTL vs. LLTL.…”

Section: Metabolic Phenotypementioning

confidence: 81%

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Repeated maximal‐intensity hypoxic exercise superimposed to hypoxic residence boosts skeletal muscle transcriptional responses in elite team‐sport athletes

et al. 2017

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“…, Collu‐Marchese et al . ), appears also as a plausible molecular explanation for the beneficial adaptations observed in LHTLH vs. LHTL vs. LLTL.…”

Section: Discussionmentioning

confidence: 87%

Section: Metabolic Phenotypementioning

confidence: 81%

Repeated maximal‐intensity hypoxic exercise superimposed to hypoxic residence boosts skeletal muscle transcriptional responses in elite team‐sport athletes

et al. 2017

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“…In addition, there creates a ATP deprivation in the cells with increase in AMP:ATP ratio. All these events lead to activation of AMPK, a energy sensor of the body, which upon phosphorylation restores the ATP level by phosphorylating peroxisome proliferator activated receptor γ-coactivator 1α (PGC-1α), a crucial regulator of mitochondrial biogenesis (Wengong et al 2003;Collu-Marchese et al 2015;Guadalupe-Grau et al 2017). Activated PGC-1 allows mitochondria to get adapted to the stress condition imposed by increased energy expenditure, as observed in exercise, thereby maintaining them in functional state.…”

Section: Resultsmentioning

confidence: 99%

Effects of sea horse (Hippocampus abdominalis)-derived protein hydrolysate on skeletal muscle development

Muthuramalingam

Kim

Jeon

et al. 2017

JABC

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Hippocampus abdominalis, the big belly sea horse, is widely known for its medicinal value in Chinese folk medicine. In this study, extract obtained by proteolytic degradation of this species was investigated for its effects on skeletal muscle development, both in vitro and in vivo. Muscle cell lines (C 2 C 12 and L 6 ) treated with the bioactive peptide did not have any detrimental effects on the cell viability, which was above 80%. Optical microscopy analysis on the morphology of the sea horse extract (SHE)-treated cells showed enhanced differentiating ability with myotube formation. Moreover, cells incubated with the hydrolysate displayed decreased proliferation rate, as recorded by the electric cell substrate impedance sensing system, thereby supporting enhanced differentiation. For a period of 12 weeks, mice models were fed with SHE and simultaneously subjected to treadmill exercise, which increased the expression of Myogenin, a key myogenic regulatory factor. In addition, there was an increase in the expression of AMPK-and Cytochrome C, both of which are important in mitochondrial biogenesis. Thus, the SHE from Hippocampus abdominalis can be a promising candidate as protein supplement aiding muscle development.

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“…The role of TFAM in skeletal muscle has been highlighted by muscle-specific loss-of-function studies, which have identified this protein as a required factor for maintaining normal mitochondrial respiratory chain function and muscle strength [151,154]. In skeletal muscle cells, the protein expression of TFAM and its localization to the mitochondrial matrix correlates well with the expression of mtDNA-encoded genes [157], a relationship which holds true following both chronic muscle activity and inactivity [131,134]. Increased Tfam gene expression in muscle has been reported following a single acute session of endurance exercise in both rodent and humans [158][159][160], which is not surprising since TFAM expression is regulated by PGC-1α [161], which is robustly responsive to exercise.…”

Section: Mitochondrial Transcription Factor Amentioning

confidence: 99%

Unravelling the mechanisms regulating muscle mitochondrial biogenesis

Hood

Tryon

Carter

et al. 2016

Biochemical Journal

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137

110

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Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is responsive to acute increases in contractile activity patterns (i.e. exercise) which initiate the signalling of a compensatory response, leading to the biogenesis of mitochondria and improved organelle function. Exercise also promotes the degradation of poorly functioning mitochondria (i.e. mitophagy), thereby accelerating mitochondrial turnover, and preserving a pool of healthy organelles. In contrast, muscle disuse, as well as the aging process, are associated with reduced mitochondrial quality and quantity in muscle. This has strong negative implications for whole-body metabolic health and the preservation of muscle mass. A number of traditional, as well as novel regulatory pathways exist in muscle that control both biogenesis and mitophagy. Interestingly, although the ablation of single regulatory transcription factors within these pathways often leads to a reduction in the basal mitochondrial content of muscle, this can invariably be overcome with exercise, signifying that exercise activates a multitude of pathways which can respond to restore mitochondrial health. This knowledge, along with growing realization that pharmacological agents can also promote mitochondrial health independently of exercise, leads to an optimistic outlook in which the maintenance of mitochondrial and whole-body metabolic health can be achieved by taking advantage of the broad benefits of exercise, along with the potential specificity of drug action.

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The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation

Abstract: The present study highlights the transcriptional and post-transcriptional regulation of mitochondrial transcription factor A (Tfam) during myogenesis and the relationship this has with the increase in mitochondrial content during differentiation.

Cited by 34 publications

References 26 publications

Repeated maximal‐intensity hypoxic exercise superimposed to hypoxic residence boosts skeletal muscle transcriptional responses in elite team‐sport athletes

Repeated maximal‐intensity hypoxic exercise superimposed to hypoxic residence boosts skeletal muscle transcriptional responses in elite team‐sport athletes

Effects of sea horse (Hippocampus abdominalis)-derived protein hydrolysate on skeletal muscle development

Unravelling the mechanisms regulating muscle mitochondrial biogenesis

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