The regulation of cell functions electrically using biodegradable polypyrrole–polylactide conductors

Shi, Gaoquan; Zhang, Ze; Rouabhia, Mahmoud

doi:10.1016/j.biomaterials.2008.06.010

Cited by 137 publications

(107 citation statements)

References 35 publications

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“…Fibroblasts have been shown to increase cell adhesion, spreading, and proliferation on conductive substrates, [46] and a random matrix formed by nanotubes corroborates evidence from other authors that Pluronic F-127 wrapped carbon nanotube-doped gels enhance the electrical conductivity, leading to improved cytocompatibility [26]. In the formation of a lattice, there is little difference in the observed effects below a critical threshold of conductor connectivity, but a significant step occurs once the threshold is crossed.…”

Section: Discussionsupporting

confidence: 81%

Inhibition of Mesenchymal Cell Contraction using Carbon Nanotubes

Wailes

Levi‐Polyachenko

2013

Nanomaterials and Tissue Regeneration

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Fibrosis can develop after injury in many organ systems, including the skin, lungs, and heart, yet no treatment is currently available to target the cause of fibrosis. We hypothesize that fiber-like carbon nanotubes may be able to interact with the mesenchymal cells to inhibit the contraction that can lead to fibrosis. Collagen gels were populated with human mesenchymal cells and spherical carbon black nanoparticles, singlewall carbon nanotubes (SWNT), or multi-wall carbon nanotubes (MWNT). The contraction, viability, actin content, and antioxidant capabilities of the gels were evaluated over the course of one week. The initial mechanical properties of the gels were also investigated. Both SWNT and MWNT, but not carbon black, significantly inhibited contraction while increasing proliferation. The nanotubes were effective even though cells in every gel type expressed α-smooth muscle actin, which is indicative of a procontractile, myofibroblast phenotype. The nanoparticles were shown to not affect gel stiffness. The MWNT also act as potent antioxidants, which may be the reason they minimize contraction. Our data show that carbon nanotubes can modulate the pathological activity of mesenchymal cells while increasing cell proliferation. We demonstrate that the aspect ratio of carbon nanoparticles is an important factor in mediating nanoparticle-cell interactions. Keywords Fibrosis • Collagen Gel • MWNT • SWNT • Carbon Black

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Section: Discussionsupporting

confidence: 81%

Inhibition of Mesenchymal Cell Contraction using Carbon Nanotubes

Wailes

Levi‐Polyachenko

2013

Nanomaterials and Tissue Regeneration

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“…7 The effect of PPy surfaces with or without electrical stimulation (ES) has been studied with various cell types, such as skeletal muscle cells, neurites, endothelial cells, fibroblasts, osteoblasts, and MSCs. [12][13][14][15][16][17] However, so far, the effects of PPy on osteogenic differentiation of human ASCs have not, to the best of our knowledge, been reported either with or without ES.…”

mentioning

confidence: 93%

Novel Polypyrrole-Coated Polylactide Scaffolds Enhance Adipose Stem Cell Proliferation and Early Osteogenic Differentiation

Pelto

Björninen

Pälli

et al. 2013

Tissue Engineering Part A

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“…The inherent nature of neurons is to transmit electrochemical signals throughout the nervous system and, as a result, they are highly influenced by electrical stimuli (Yu et al, 2008b). Previous studies have shown that electrical stimulation is an effective cue in stimulating either the proliferation or differentiation of various cell types McCaig and Zhao, 1997;Sun et al, 2006;Ciombor and Aaron, 1993;Aaron and Ciombor, 1993;Goldman and Pollack, 1996;Dust and Bawornluck, 2006;Shi et al, 2008;Zhao et al,1996Zhao et al, , 1999Yaoita et al,1990;Guimarda et al, 2007;Rivers et al, 2002;Jeong et al, 2008;Whitehead et al, 2007;Ateh et al, 2006;Schmidt et al, 2003;Valentini et al, 1992). In this review we discuss the electrical properties of nerve cells, the most commonly utilized conductive polymers, namely polypyrrole (PPy) and polyaniline (PANI), the principle of electrical stimulation and the application of electrical stimulation through conductive scaffolds to nerve cells.…”

Section: Introductionmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

590

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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The regulation of cell functions electrically using biodegradable polypyrrole–polylactide conductors

Cited by 137 publications

References 35 publications

Inhibition of Mesenchymal Cell Contraction using Carbon Nanotubes

Inhibition of Mesenchymal Cell Contraction using Carbon Nanotubes

Novel Polypyrrole-Coated Polylactide Scaffolds Enhance Adipose Stem Cell Proliferation and Early Osteogenic Differentiation

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

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