The Regulation of Calcium Metabolism [<i>Abridged</i>]

Buckle, Richard M.

doi:10.1177/003591577006300905

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…According to White et al [26], Concerning the role of calcium concentration in COVID-19 mortality, Lippi et al [28] found that COVID-19 pandemic severity is in part associated with lower serum concentrations of calcium. It is well-known that the ionic concentration of calcium, which is highly correlated to 25(OH)D and to 1,25(OH)2D, appears as the major factor in uencing the secretion rate of PTH [29]. PTH plays a critical role in calcium homeostasis, defending against hypocalcemia by acting on target organs such bone and kidney in order to stimulate bone resorption, to promote renal conservation of calcium, and to induce production of 1,25(OH)2D, which in turn enhances intestinal calcium absorption [30].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and COVID-19: Some Implications

Emilion¹,

Emilion²

2020

Preprint

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Background Vitamin D is essential for the maintenance of good health and its status is defined by the level of serum 25-hydroxyvitamin (25(OH)D). Negative correlations between mean levels of 25(OH)D per country and the number of COVID-19 confirmed cases per one million population, and COVID-19 mortality per one million population, were recently observed. The aim of this study was to identify levels of 25(OH)D below which, rates of COVID-19 confirmed cases, mortality and lethality, increase significantly.Methods A data table found in the literature, containing a list of twenty countries and their corresponding mean level of 25(OH)D was updated with COVID-19 latest numbers of confirmed cases and mortality rates. Cut points of 25(OH)D below which rates were significantly higher were found according to various statistical criteria: absolute difference of means, t-test p-values, between class variance, entropy. Thresholds of 25(OH)D below which there can be a significant rise of COVID-19 confirmed cases, mortality and lethality, were found performing a Gaussian kernel regression. Results All the criteria yielded 25(OH)D cut off points at 50 ± 10 nmol/L for Cases and Mortality variables and at 60 ± 10 nmol/L for Lethality variable. A Gaussian kernel regression showed a significant rise in the rates of COVID-19 confirmed cases, mortality and lethality, below 25(OH)D levels of 60 ± 6 nmol/L. Conclusion In this study, our method provided a reliable estimate (95 % confidence interval) of 25(OH)D levels, of 60 ± 6 nmol/L, in the range of vitamin D insufficiency, below which rates of COVID-19 confirmed cases per one million population, rates of COVID-19 mortality per one million population increased. We found that 25(OH)D levels below 50 ± 10 nmol/L, mainly in the range of vitamin D deficiency, associate with highest COVID-19 mortality rates. Therefore, we suggest that 25(OH)D concentrations should be above 60 ± 6 nmol/L to reduce morbidity and mortality during the COVID-19 pandemic.

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