The Regulation of Basement Membrane Formation and Cell‐Matrix Interactions by Defined Supramolecular Complexes

Martin, George R.; Kleinman, Hynda K.; Tekranova, V. P.; Ledbetter, Steven; Hassell, John R.

doi:10.1002/9780470720899.ch13

Cited by 43 publications

(27 citation statements)

References 70 publications

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“…Cancer cell adhesion to the basement membrane involves attachment to many of the same adhesion molecules involved in intravasation. The subendothelial matrix consists of collagens, particularly type IV and VIII, fibronectin, laminin and heparan sulfated proteoglycans such as perlecan, glypican and entactin [198][199][200][201][202][203][204]. Expression of some of these components may be tissue specific.…”

Section: Transit Of the Endothelial Basement Membranementioning

confidence: 99%

Stepping out of the flow: capillary extravasation in cancer metastasis

Miles

Pruitt

Golen

et al. 2007

Clin Exp Metastasis

229

221

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In order for cancer cells to successfully colonize a metastatic site, they must detach from the primary tumor using extracellular matrix-degrading proteases, intravasate and survive in the circulation, evade the immune response, and extravasate the vasculature to invade the target tissue parenchyma, where metastatic foci are established. Though many of the steps of metastasis are widely studied, the precise cellular interactions and molecular alterations associated with extravasation are unknown, and further study is needed to elucidate the mechanisms inherent to this process. Studies of leukocytes localized to inflamed tissue during the immune response may be used to elucidate the process of cancer extravasation, since leukocyte diapedesis through the vasculature involves critical adhesive interactions with endothelial cells, and both leukocytes and cancer cells express similar surface receptors capable of binding endothelial adhesion molecules. Thus, leukocyte extravasation during the inflammatory response has provided a model for transendothelial migration (TEM) of cancer cells. Leukocyte extravasation is characterized by a process whereby rolling mediated by cytokine-activated endothelial selectins is followed by firmer adhesions with beta1 and beta2 integrin subunits to an activated endothelium and subsequent diapedesis, which most likely involves activation of Rho GTPases, regulators of cytoskeletal rearrangements and motility. It is controversial whether such selectin-mediated rolling is necessary for TEM of cancer cells. However, it has been established that similar stable adhesions between tumor and endothelial cells precede cancer cell transmigration through the endothelium. Additionally, there is support for the preferential attachment of tumor cells to the endothelium and, accordingly, site-specific metastasis of cancer cells. Rho GTPases are critical to TEM of cancer cells as well, and some progress has been made in understanding the specific roles of the Rho GTPase family, though much is still unknown. As the mechanisms of cancer TEM are elucidated, new approaches to study and target metastasis may be utilized and developed.

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Section: Transit Of the Endothelial Basement Membranementioning

confidence: 99%

Stepping out of the flow: capillary extravasation in cancer metastasis

Miles

Pruitt

Golen

et al. 2007

Clin Exp Metastasis

229

221

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“…The intent of this topical issue on basement membranes was to return to the basic paradigm of the basement membrane MATRISOME model as put forth by Martin et al (1984) and merge the MATRISOME concept with those previous tenets put forth by Clifford Grobstein in 1967. Thus during the development phase of this issue, contributors were sought out whose research interests fell under the umbrella of the basement membrane MATRISOME.…”

Section: Microscopy Research and Techniquementioning

confidence: 96%

“…(Bar 5 30 lm). Figure 2 depicts the basic structure of the basement membrane MATRISOME as proposed by Martin et al (1984). Both type IV collagens and laminins have the ability to form separate networks that can be linked to one another via nidogen/entactin.…”

Section: Microscopy Research and Techniquementioning

confidence: 97%

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Introduction—Basement membranes: From the matrisome to beyond

McCarthy

2008

Microscopy Res & Technique

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“…These studies have impacted the biomedical sciences in many areas, helping to understand such phenomenon as cancer cell metastasis, angiogenesis, as well as the degradation of enamel matrix proteins during enamel biomineralization 62–64 . Studies on the metabolism of the extracellular matrix led to the formulation of an artificial basement membrane, an event that allowed cells to be maintained in a three-dimensional architecture that resembled a native tissue 65 .…”

Section: Tissue Destructive Enzymesmentioning

confidence: 99%

Science Is the Fuel for the Engine of Technology and Clinical Practice

Snead¹,

Slavkin²

2009

The Journal of the American Dental Association

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The biological, chemical, behavioral and physical sciences provide the fuel for the engine of innovation and discovery that continuously improve the quality of the human condition. Dramatic breakthroughs in computer power derived from the digital revolution, provides extraordinary computational capacity for diagnostic imaging, bioinformatics (the science of information), and numerous aspects of how we practice dentistry in the 21st century. Moreover, the biological revolution with the elucidation of the structure of DNA, celebrated its 56th anniversary in May 1, provides the body of knowledge proving itself to be catalytic for discoveries that improve patient care---diagnostics, treatments and therapeutics, and new biomaterials. Humanity's most basic and recognizable characteristics are now understood through the elucidation of our genome and proteome 2, 3 the genes and the proteins they encode. We are now beginning to utilize "personalized" genetic predisposition and so much more. These and so many more "ways of knowing" continue to fuel advances in the scientific disciplines that support our dental profession and form the basis for new diagnostic tests, affording new therapies and procedures that improve the quality of life for our patients. And we are today on the thresh hold of stem cell biology applied to regenerative medicine and dentistry. We have entered an era when engineering biological solutions to the loss of tissues and organs as a consequence of disease are now realities.

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The Regulation of Basement Membrane Formation and Cell‐Matrix Interactions by Defined Supramolecular Complexes

Cited by 43 publications

References 70 publications

Stepping out of the flow: capillary extravasation in cancer metastasis

Stepping out of the flow: capillary extravasation in cancer metastasis

Introduction—Basement membranes: From the matrisome to beyond

Science Is the Fuel for the Engine of Technology and Clinical Practice

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