The regulation of a variability of somatic mammalian cell genome under the influence of exogeneous biological factors

Cytogenetic aberrations in peripheral blood mononuclear cells in acute Lyme borreliosis patients

“…Chromatid aberrations are assumed to be related to disturbances in the process of break reparation in double stranded DNA [19]. Chromatid breaks and fragments are the most frequent types of chromosomal aberrations caused by various infectious agents, including aden oviruses, simple herpes viruses, influenza viruses, tick borne encephalitis, measles, and some bacteriamycoplasma, shigella, and salmonella [3][4][5][6][7][8].…”

“…From the 1960s, it has become obvi ous that viruses might be capable of inducing various aberrations in the nuclear apparatus of a cell [2,3]. Subsequent research demonstrated that cytogenetic aberrations might be caused by both intracellular par asites, including viruses, and extracellular infectious agents, including bacteria, protozoa, and helminthes [4][5][6][7][8]. It is suggested that the induction of chromo somal aberrations is mediated by the occurrence of inflammatory and immunopathological processes in a patient's body.…”

Regulation of mutagenesis by exogenous biological factors in the eukaryotic cell systems

“…It is possible to make some conclusions about possible mecha- [3,12,13]. It seems to be the most probable explanation that exogenous DNAs which keep matrix properties have regulatory and information impact on cell DNA via the systems for maintenance of genetic stability and involve the same mechanisms as at spontaneous mutagenesis but with participation of alien genetic materials [69,70].…”

“…2). The early E1 area revealed the maximal mutagenic [7,42,43,69,70] and transforming activity [71,76]. The function of proteins of E1A operon consists, mainly, in immortalization of primary mammalian cells, and the proteins encoded by E1B operon are necessary for both induction, and maintenance of transformed state [76].…”

“…1). The remote mutagenic effect was synchronized with the maximum of tumors induced by oncovirus [7,52,53,69,70].…”