The Regulation Mechanisms and Clinical Application of MicroRNAs in Myocardial Infarction: A Review of the Recent 5 Years

Wu, Chan; Liu, Bing-Hong; Wang, Ruiying; Li, Gang

doi:10.3389/fcvm.2021.809580

Cited by 13 publications

(12 citation statements)

References 151 publications

(136 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR-548 downregulated HMGB1 in human amniotic epithelial cells ( 68 ) and activation of HMGB1 in bone marrow stem cells stimulates proliferation and angiogenesis ( 69 ). Therefore, delivery of miR-548 to recipient HCAEC may engage the HMGB1 pathways and therefore reduce proliferation and tube formation, Our results also indicate that all of the miRNAs that were reported to induce angiogenesis in coronary endothelium post-ischemia ( 14 ) are, in fact, not detectable in our EV populations and perhaps it is not surprising that the functional miRNA cargo in our vesicles do not support pro-angiogenic mechanisms ( Figure 7 ). Future studies are granted to validate the role of miRNA EVs in coronary angiogenesis and to identify potential therapeutic targets.…”

Section: Discussionmentioning

confidence: 72%

Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells

Carter

Mathiesen

Miller

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the most prominent cause of death of adults in the United States with coronary artery disease being the most common type of CVD. Following a myocardial event, the coronary endothelium plays an important role in the recovery of the ischemic myocardium. Specifically, endothelial cells (EC) must be able to elicit a robust angiogenic response necessary for tissue revascularization and repair. However, local or distant cues may prevent effective revascularization. Extracellular vesicles (EV) are produced by all cells and endothelium is a rich source of EVs that have access to the main circulation thereby potentially impacting local and distant tissue function. Systemic inflammation associated with conditions such as obesity as well as the acute inflammatory response elicited by a cardiac event can significantly increase the EV release by endothelium and alter their miRNA, protein or lipid cargo. Our laboratory has previously shown that EVs released by adipose tissue endothelial cells exposed to chronic inflammation have angiostatic effects on naïve adipose tissue EC in vitro. Whether the observed effect is specific to EVs from adipose tissue endothelium or is a more general feature of the endothelial EVs exposed to pro-inflammatory cues is currently unclear. The objective of this study was to investigate the angiostatic effects of EVs produced by EC from the coronary artery and adipose microvasculature exposed to pro-inflammatory cytokines (PIC) on naïve coronary artery EC. We have found that EVs from both EC sources have angiostatic effects on the coronary endothelium. EVs produced by cells in a pro-inflammatory environment reduced proliferation and barrier function of EC without impacting cellular senescence. Some of these functional effects could be attributed to the miRNA cargo of EVs. Several miRNAs such as miR-451, let-7, or miR-23a impact on multiple pathways responsible for proliferation, cellular permeability and angiogenesis. Collectively, our data suggests that EVs may compete with pro-angiogenic cues in the ischemic myocardium therefore slowing down the repair response. Acute treatments with inhibitors that prevent endogenous EV release immediately after an ischemic event may contribute to better efficacy of therapeutic approaches using functionalized exogenous EVs or other pro-angiogenic approaches.

show abstract

Section: Discussionmentioning

confidence: 72%

Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells

Carter

Mathiesen

Miller

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Jaguszewski et al ( 22 ) reported a signature of four circulating miRs as a robust biomarker to distinguish tako-tsubo syndrome from patients with AMI, which highlighted distinct characteristics of the miR profile in clinically indistinguishable cardiovascular diseases. Various miRs have been widely studied for their modulation of cardiomyocyte apoptosis, inflammation, angiogenesis, and fibrosis of AMI ( 23 ). Of these, miR-214 is highly expressed in the sera of elderly patients with AMI and may inhibit myocardial cell apoptosis by inhibiting the expression of miR-214 target genes, including the p53-upregulated modulator of apoptosis, PTEN, Bcl-2-associated X, and caspase 7 ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of circulating microRNA-21-5p and microRNA-126 in patients with acute myocardial infarction and infarct-related artery total occlusion

Gao

Hao

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundCardiovascular disease, including acute myocardial infarction (AMI), is a major global cause of mortality and morbidity. Specificity and sensitivity limit the utility of classic diagnostic biomarkers for AMI. Therefore, it is critical to identify novel biomarkers for its accurate diagnosis. Cumulative studies have demonstrated that circulating microRNAs (miRs) participate in the pathophysiological processes of AMI and are promising diagnostic biomarkers for the condition. This study aimed to ascertain the diagnostic accuracy of circulating miR-21-5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).MethodsThe expression of miR-21-5p and miR-126 was examined separately in 50 healthy subjects, 51 patients with IR-ATO AMI, and 49 patients with IR-BVR AMI using quantitative real-time polymerase chain reaction.ResultsWhen compared with the control group, the IR-ATO AMI group exhibited increased miR-21-5p (p < 0.0001) and miR-126 (p < 0.0001), and the IR-BVR AMI group exhibited increased miR-21-5p (p < 0.0001). However, there was no significant difference in miR-126 between the IR-BVR AMI and the control groups. A Spearman's correlation coefficient showed a strong correlation was found between miR-21-5p, miR-126, cardiac troponin-I, and creatine kinase isoenzyme in all three groups, while a receiver operating characteristic analysis revealed that miR-21-5p and miR-126 exhibited considerable diagnostic accuracy for IR-ATO AMI.ConclusionCirculating miR-21-5p and miR-126 may be promising prognostic biomarkers for patients with AMI and IR-ATO.

show abstract

“…ncRNAs play a significant role in the development of cardiovascular disease by exerting essential functions in the regulation of gene expression at both the transcriptional and posttranscriptional levels. miRNAs offer a flexible means of gene control and have a role in several cardiovascular processes 86 . For example, miRNAs play a crucial role in modulating gene expression through posttranscriptional mechanisms.…”

Section: Noncoding Rnas In Cardiomyopathiesmentioning

confidence: 99%

Crosstalk of NLRP3 inflammasome and noncoding RNAs in cardiomyopathies

Jafari,

Shahabi Rabori,

Zolfi Gol

et al. 2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) identified as a serious public health problem. Although there is a lot of evidence that inflammatory processes play a significant role in the progression of CVDs, however, the precise mechanism is not fully understood. Nevertheless, recent studies have focused on inflammation and its related agents. Nucleotide oligomerization domain‐, leucine‐rich repeat‐, and pyrin domain‐containing protein 3 (NLRP3) is a type of pattern recognition receptor (PRR) that can recognize pathogen‐associated molecular patterns and trigger innate immune response. NLRP3 is a component of the NOD‐like receptor (NLR) family and have a pivotal role in detecting damage to cardiovascular tissue. It is suggested that activation of NLRP3 inflammasome leads to initiating and propagating the inflammatory response in cardiomyopathy. So, late investigations have highlighted the NLRP3 inflammasome activation in various forms of cardiomyopathy. On the other side, it was shown that noncoding RNAs (ncRNAs), particularly, microRNAs, lncRNAs, and circRNAs possess a regulatory function in the immune system's inflammatory response, implicating their involvement in various inflammatory disorders. In addition, their role in different cardiomyopathies was indicated in recent studies. This review article provides a summary of recent advancements focusing on the function of the NLRP3 inflammasome in common CVDs, especially cardiomyopathy, while also discussing the therapeutic potential of inhibiting the NLRP3 inflammasome regulated by ncRNAs.

show abstract

The Regulation Mechanisms and Clinical Application of MicroRNAs in Myocardial Infarction: A Review of the Recent 5 Years

Cited by 13 publications

References 151 publications

Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells

Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells

Prognostic value of circulating microRNA-21-5p and microRNA-126 in patients with acute myocardial infarction and infarct-related artery total occlusion

Crosstalk of NLRP3 inflammasome and noncoding RNAs in cardiomyopathies

Contact Info

Product

Resources

About