The regulation and function of micrornas in kidney diseases

Wei, Qingqing; Mi, Qing Sheng; Dong, Zheng

doi:10.1002/iub.1174

Cited by 90 publications

(80 citation statements)

References 146 publications

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“…Recent studies have revealed the critical role played by miRNAs in modulating multiple cellular and molecular pathways that contribute to AKI (159). In one of the initial studies (158) examining the functional role of miRNAs in AKI, it was found that global miRNA depletion by conditional Dicer ablation in renal tubular cells provides significant protection from ischemic AKI.…”

Section: Acute Kidney Injurymentioning

confidence: 99%

“…Although, extensive human studies are still required, initial steps have been taken to demonstrate the potential utility of miRNAs, especially in the urine, for assessing AKI. Multiple studies (90,96,104,113,124,155,159,160) in humans and animal models have identified specific miRNAs as potential diagnostic markers for the early detection of AKI. Such approaches would be of tremendous clinical value to prevent progression from AKI to renal failure.…”

Section: Acute Kidney Injurymentioning

confidence: 99%

“…Along with the above-mentioned renal diseases, miRNAs have also been studied in lupus nephritis, acute allograft rejection, hypertensive nephropathy, and other disorders (141,159). Altered expression of several miRNAs has been demonstrated in lupus nephritis (131,132,141).…”

Section: Other Renal Diseases and Conditionsmentioning

confidence: 99%

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Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases

Bhatt

Kato

Natarajan

2016

American Journal of Physiology-Renal Physiology

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MicroRNAs (miRNA) are endogenously produced short noncoding regulatory RNAs that can repress gene expression by posttranscriptional mechanisms. They can therefore influence both normal and pathological conditions in diverse biological systems. Several miRNAs have been detected in kidneys, where they have been found to be crucial for renal development and normal physiological functions as well as significant contributors to the pathogenesis of renal disorders such as diabetic nephropathy, acute kidney injury, lupus nephritis, polycystic kidney disease, and others, due to their effects on key genes involved in these disease processes. miRNAs have also emerged as novel biomarkers in these renal disorders. Due to increasing evidence of their actions in various kidney segments, in this mini-review we discuss the functional significance of altered miRNA expression during the development of renal pathologies and highlight emerging miRNA-based therapeutics and diagnostic strategies for early detection and treatment of kidney diseases.

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Section: Acute Kidney Injurymentioning

confidence: 99%

Section: Acute Kidney Injurymentioning

confidence: 99%

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Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases

Bhatt

Kato

Natarajan

2016

American Journal of Physiology-Renal Physiology

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“…In kidneys, a number of microRNAs have been identified to be essential for renal development and function. Moreover, specific microRNAs have been implicated in the pathogenesis of both acute and chronic kidney diseases (12)(13)(14)(15).…”

mentioning

confidence: 99%

MicroRNA-375 Is Induced in Cisplatin Nephrotoxicity to Repress Hepatocyte Nuclear Factor 1-β

Hao

Lou

Wei

et al. 2017

Journal of Biological Chemistry

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Edited by Joel GottesfeldNephrotoxicity is a major adverse effect of cisplatin-mediated chemotherapy in cancer patients. The pathogenesis of cisplatininduced nephrotoxicity remains largely unclear, making it difficult to design effective renoprotective approaches. Here, we have examined the role of microRNAs (miRNAs) in cisplatininduced nephrotoxicity. We show that cisplatin nephrotoxicity was not affected by overall depletion of both beneficial and detrimental miRNAs from kidney proximal tubular cells in mice in which the miRNA-generating enzyme Dicer had been conditionally knocked out. To identify miRNAs involved in cisplatin nephrotoxicity, we used microarray analysis to profile miRNA expression and identified 47 up-regulated microRNAs and 20 down-regulated microRNAs in kidney cortical tissues. One upregulated miRNA was miR-375, whose expression was also induced in cisplatin-treated renal tubular cells. Interestingly, inhibition of miR-375 decreased cisplatin-induced apoptosis, suggesting that miR-375 is a cell-damaging or pro-apoptotic agent. Blockade of P53 or NF-B attenuated cisplatin-induced miR-375 expression, supporting a role of P53 and NF-B in miR-375 induction. We also identified hepatocyte nuclear factor 1 homeobox B (HNF-1␤) as a key downstream target of miR-375. Of note, we further demonstrated that HNF-1␤ protected renal cells against cisplatin-induced apoptosis. Together, these results suggest that upon cisplatin exposure, P53 and NF-B collaboratively induce miR-375 expression, which, in turn, represses HNF-1␤ activity, resulting in renal tubular cell apoptosis and nephrotoxicity.

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“…Other observations have been supporting the hypothesis of active sorting; high EVs miR-NA level than that contained in the parental cells which may be explained by the observation that certain miRNAs can be lost during extraction from samples [66]. The differences in the blood collection protocols willimpact the comparison between extracellular versus intracellular miRNA profiles expressed in different cell types [67]- [71].…”

Section: Mirna Release: Active Sorting or Byproduct Of Cell Activity!mentioning

confidence: 78%

Extracellular Micro-RNAs in Health and Disease: Basic Science, Biogenesis and Release

Nassar¹,

El-Ansary²,

Fayyad³

et al. 2016

AJMB

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The regulation and function of micrornas in kidney diseases

Cited by 90 publications

References 146 publications

Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases

Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases

MicroRNA-375 Is Induced in Cisplatin Nephrotoxicity to Repress Hepatocyte Nuclear Factor 1-β

Extracellular Micro-RNAs in Health and Disease: Basic Science, Biogenesis and Release

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