The regularity of smoked marijuana self-administration

Foltin, Richard W.; Fischman, Marian W.; Brady, Joseph V.; Capriotti, Richard M.; Emurian, Cleeve S.

doi:10.1016/0091-3057(89)90184-6

Cited by 11 publications

(11 citation statements)

References 10 publications

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“…Indeed, subjective-effect ratings provide some support for this perspective, as ratings of "Friendly" and "Social" were significantly increased by the 20-mg Δ 9 -THC dose. This observation is congruent with other data that suggest drug self-administration is influenced by social factors that are difficult to establish in traditional laboratories (Foltin et al 1989;Doty and de Wit 1995). While some social factors may have influenced Δ 9 -THC choice behavior, it is important to note that participants' choice behavior was not influenced by choice selections of their fellow participants, as no group differences in choice behavior was observed.…”

Section: Discussionsupporting

confidence: 88%

“…Consistent with this, findings from several controlled laboratory studies employing human participants indicate that marijuana serves as a reinforcer (e.g., Mendelson and Mello 1984;Foltin et al 1989;Chait and Zacny 1992). Although smoked marijuana contains over 400 other chemicals (∼60 are cannabinoids), its reinforcing effects are known to be due to Delta-9-tetrahydrocannabinol (Δ 9 -THC; Chait and Burke 1994;Kelly et al 1994Kelly et al , 1997.…”

Section: Introductionmentioning

confidence: 73%

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Reinforcing effects of oral Δ9-THC in male marijuana smokers in a laboratory choice procedure

et al. 2005

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 73%

Reinforcing effects of oral Δ9-THC in male marijuana smokers in a laboratory choice procedure

et al. 2005

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“…Cannabinoids stimulate appetite in human volunteers89 and AIDS patients,90 but not in patients with advanced cancer 91…”

Section: Potential Therapeutic Applications In the Gutmentioning

confidence: 99%

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects

Izzo

Camilleri

2008

Gut

187

171

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A multitude of physiological effects and putative pathophysiological roles have been proposed for the endogenous cannabinoid system in the gastrointestinal tract, liver and pancreas. These range from effects on epithelial growth and regeneration, immune function, motor function, appetite control, fibrogenesis and secretion. Cannabinoids have the potential for therapeutic application in gut and liver diseases. Two exciting therapeutic applications in the area of reversing hepatic fibrosis as well as antineoplastic effects may have a significant impact in these diseases. This review critically appraises the experimental and clinical evidence supporting the clinical application of cannabinoid receptor-based drugs in gastrointestinal, liver and pancreatic diseases. Application of modern pharmacological principles will most probably expand the selective modulation of the cannabinoid system peripherally in humans. We anticipate that, in addition to the approval in several countries of the CB(1) antagonist, rimonabant, for the treatment of obesity and associated metabolic dysfunctions, other cannabinoid modulators are likely to have an impact on human disease in the future, including hepatic fibrosis and neoplasia.

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“…The potential importance of these factors is provided by studies that suggest that the reinforcing properties of drugs, including marijuana, are influenced by social factors that are challenging to replicate in a laboratory setting (Doty & de Wit, 1995; Foltin et al, 1989). For example, tobacco smoking is legal and smoked in somewhat different situations than marijuana.…”

Section: Discussionmentioning

confidence: 99%

Marijuana and tobacco exposure predict affect-regulation expectancies in dual users

Martens

Gilbert

2008

Addictive Behaviors

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In order to better compare affect-related expectancies for tobacco and marijuana smoking, associations of marijuana and tobacco exposure to negative affect reduction (NAR), positive affect enhancement (PAE), and related smoking outcome expectancies were assessed in young individuals who reported smoking both marijuana and tobacco on a regular basis (dual users). More frequent smoking of a given substance was associated with expectations of greater NAR and PAE by that substance while duration of exposure did not reliably predict NAR or PAE drug expectancies. Contrary to expectations, individuals anticipating greater NAR and/or PAE for one substance did not exhibit corresponding expectancies for the other drug. These findings suggest that exposure duration may be less important than current usage levels in influencing affect expectancies and that the affect-related expectancies for tobacco and marijuana are largely independent of each other.

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The regularity of smoked marijuana self-administration

Cited by 11 publications

References 10 publications

Reinforcing effects of oral Δ9-THC in male marijuana smokers in a laboratory choice procedure

Reinforcing effects of oral Δ9-THC in male marijuana smokers in a laboratory choice procedure

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects

Marijuana and tobacco exposure predict affect-regulation expectancies in dual users

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