The regional neuronal activity in left posterior middle temporal gyrus is correlated with the severity of chronic aphasia

Li, Jianlin; Du, Dunren; Gao, Wei; Sun, Xichun; Xie, Haizhu; Zhang, Gang; Li, Jian; Li, Honglun; Li, Kefeng

doi:10.2147/ndt.s140091

Cited by 12 publications

(6 citation statements)

References 41 publications

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“… 25 When positron emission technology was used to analyze the semantic processing of words, the ITG showed obvious activation. 26 Correspondingly, when the ITG is damaged in patients with aphasia, there are often semantic defects, 27 and some studies have observed ITG atrophy in semantic dementia, 28 which supports their participation in semantic language understanding. Through meta-analysis connectivity research of the ITG, it was found that, although the ITG participates in language processing, it cannot be considered as the core language processing area, and it can be understood as a kind of language processing edge area.…”

Section: Discussionmentioning

confidence: 91%

Investigation of Changes in Retinal Detachment-Related Brain Region Activities and Functions Using the Percent Amplitude of Fluctuation Method: A Resting-State Functional Magnetic Resonance Imaging Study

Yang¹,

Chen

et al. 2021

NDT

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Purpose The percent amplitude of fluctuation (PerAF) method was used to study the changes in neural activities and functions in specific brain regions of patients with a retinal detachment (RD). Patients and Methods In this study, we recruited 15 RD patients (nine males and six females) and 15 healthy controls (HCs) matched for gender, age, and weight. All participants were scanned with resting functional magnetic resonance imaging (rs-fMRI). The PerAF method was then used for data analysis to evaluate and detect changes in neural activity in relevant brain regions. Receiver operating characteristic (ROC) curve analysis was used to evaluate the two groups. Results The PerAF signal values of the right fusiform gyrus and the left inferior temporal gyrus of RD patients were significantly higher than those of HCs. This may indicate changes in neural activity and function in the related brain regions. The anxiety and depression scores of hospital anxiety and depression scale (HADS) and the durations in RD patients were positively correlated with the PerAF values of the left inferior temporal gyrus. Conclusion In this study, we demonstrated that there were significant changes in the PerAF values in specific areas of the brain in patients with RD. The change of PerAF values represent the changes of BOLD signal intensity, which reflect the hyperactivity or weakening of specific brain regions in RD patients, which are helpful to predict the development and prognosis of RD patients, and play an important role in the early diagnosis of RD. In addition, according to the results, changes in neural activity in specific brain regions of RD patients increase the risk of brain dysfunction related diseases, which may help to understand the pathological mechanism of vision loss in RD patients.

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Section: Discussionmentioning

confidence: 91%

Investigation of Changes in Retinal Detachment-Related Brain Region Activities and Functions Using the Percent Amplitude of Fluctuation Method: A Resting-State Functional Magnetic Resonance Imaging Study

Yang¹,

Chen

et al. 2021

NDT

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“…Brodmann area 21 [middle temporal gyrus (MTG)] is implicated in sound recognition as well as word and picture semantic processing 74 , language processing 75 , decoding gaze direction, deductive reasoning 76 plus intelligible speech and processing of verbal mental arithmetic 77 . Brodmann area 40 (supramarginal gyrus) plays a role in visual word recognition, auditory memory processing, and emotion recognition 78 – 80 .…”

Section: Resultsmentioning

confidence: 99%

Effect of berry-based supplements and foods on cognitive function: a systematic review

Bonyadi

Dolatkhah

Salekzamani

et al. 2022

Sci Rep

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In the current decade, a growing body of evidence has proposed the correlation between diet and cognitive function or dementia in the ageing population. This study was designed to appraise discoveries from the randomized controlled trials to confirm the effects of berry-based supplements or foods on cognitive function in older adults. PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, EMBASE, Google Scholar, and ProQuest as well as SID, Magiran, and Iranmedex electronic databases were explored for human interventional studies up to March 2021. In total, eleven articles were identified using frozen blueberry (n = 4 studies), blueberry concentrate (n = 2), beverage (n = 3), capsule (n = 1), extract and powder (n = 1). These studies had been performed among older people with no recognized cognitive impairment or mild cognitive impairment (MCI). The primary outcomes included global cognitive function, psychomotor function, learning and memory, working memory capacity, executive functions, and brain perfusion/activity. To our knowledge, this is the first systematic review of available clinical trials on the effects of berry-based supplements and foods on cognitive performances as well as brain perfusion parameters among the elderly with normal cognition or MCI. Existing evidence concludes that berry-based supplements and foods have beneficial effects on resting brain perfusion, cognitive function, memory performance, executive functioning, processing speed, and attention indices.

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“…The temporal lobe has always been considered as an important region for semantic processing and sentence production, and comprehension defificits were associated with lesions in the temporal lobe, including the anterior and posterior superior temporal gyri (aSTG, pSTG), the anterior and posterior middle temporal gyri (aMTG, pMTG), the auditory association areas [planum temporale (PT) and planum polare (PP)], the temporal pole (TP), the MTG temporooccipital (toMTG) regions, superior marginal gyrus (SMG), angular gyrus (AG), CO and PO. Li et al (45) found that the regional neuronal activity in left pMTG was correlated with the severity of chronic aphasia. Sebastian and his colleagues (46) observed four aphasia patients due to posterior cerebral artery stroke and found that improved naming skills were associated with increased FC within and between the left and right hemispheres language regions (IFG, STG, MTG, inferior temporal gyrus (ITG), SMG and AG), while the patients of whom the language function did not improve showed an opposite pattern.…”

Section: Discussionmentioning

confidence: 99%

Exploring the functional connectivity characteristics of brain networks in post-stroke patients with global aphasia: a healthy control based resting-state fMRI study

Xu¹,

Ren²,

Fang³

et al. 2021

Ann Palliat Med

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Background: In this study, resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the characteristics of functional connectivity of brain networks in patients with post-stroke global aphasia (PGA).Methods: PGA patients hospitalized in Wuxi Tongren Rehabilitation Hospital during their subacute stage were selected as a case group, and healthy volunteers with matching age, sex, and education level were selected as healthy controls (HCs). rs-fMRI scans were performed to compare the differences of functional connectivity in resting-state networks (RSNs) and in the whole brain between the two groups.Results: A total of 11 patients with PGA and 11 HCs were included in this study. PGA patients showed decreased inter-hemispheric connectivity of homologs within the sensorimotor network (SMN), salience network, and language network. In the analysis of the whole brain functional connections, PGA patients exhibited both inter-hemispheric and intra-hemispheric hypoconnectivity when compared with HCs. However, they exhibited some stronger connections than HCs between the language network and cerebellar network, which may indicate compensatory mechanisms.Conclusions: Using rs-fMRI to research differences in the functional connectivity of brain networks in post-stroke global aphasia will help us further understand it's neurological mechanism and provide an important basis for the accurate selection of therapeutic targets in the future to promote better recovery of language function.

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The regional neuronal activity in left posterior middle temporal gyrus is correlated with the severity of chronic aphasia

Cited by 12 publications

References 41 publications

Investigation of Changes in Retinal Detachment-Related Brain Region Activities and Functions Using the Percent Amplitude of Fluctuation Method: A Resting-State Functional Magnetic Resonance Imaging Study

Investigation of Changes in Retinal Detachment-Related Brain Region Activities and Functions Using the Percent Amplitude of Fluctuation Method: A Resting-State Functional Magnetic Resonance Imaging Study

Effect of berry-based supplements and foods on cognitive function: a systematic review

Exploring the functional connectivity characteristics of brain networks in post-stroke patients with global aphasia: a healthy control based resting-state fMRI study

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