The regenerative role of mast cells and mesenchymal stem cells in histopathology of sciatic nerve and tibialis cranialis muscle, following denervation in rats
Abstract:Atrophy of the leg muscles following sciatic nerve transection can lead to the death of myofibers. The aim of this study was to evaluate the process of nerve and muscle regeneration using mast cells and mesenchymal stem cells.
In this study, 90 adult male Wistar rats weighing 150-200g were randomly divided into six main groups (n=15) and each group into three subgroups (2, 4 and 8 weeks, n=5). Groups: control; without surgery, transection (Tr); Fixing the two ends of the transected sciatic nerve (8 mm gap) in… Show more
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