The regenerative mechanisms of platelet-rich plasma: A review

Santos, Rafael Gonzalez dos; Santos, Gabriel Silva; Alkass, Natasha; Chiesa, Tania Liana; Azzini, Gabriel Ohana Marques; Fonseca, Lucas Furtado da; Santos, Antonio Fernando dos; Rodrigues, Bruno; Mosaner, Tomas; Lana, José Fábio Santos Duarte

doi:10.1016/j.cyto.2021.155560

Cited by 66 publications

(65 citation statements)

References 87 publications

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“…This process has been known for more than 50 years, and has previously demonstrated a certain degree of efficacy in some health conditions requiring tissue healing and regeneration, notably in orthopedics, cardiothoracic surgery, plastic surgery, dermatology, dentistry, and diabetic wound healing [ 6 ]. The mechanism of action of PRP is complex and remains incompletely understood: after activation, platelets release a series of cytokines, growth factors, and hormones, capable, among other actions, of attracting stem cells, enhancing angiogenesis, and activating cellular differentiation and proliferation [ 7 ]. Surprisingly, very few attempts at using PRP have been undertaken in the gynecological field until recently, when it was suggested as a means to improve pregnancy rates in some women with thin endometrial lining and recurrent implantation failures, and in some poor responders.…”

Section: Resultsmentioning

confidence: 99%

Restoration of Fertility in Patients with Spontaneous Premature Ovarian Insufficiency: New Techniques under the Microscope

Mawet¹,

d'HAUTERIVE

Henry³

et al. 2021

JCM

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Premature ovarian insufficiency (POI), a condition affecting up to 1% of women by the age of 40 years, is characterized by an extremely low chance of spontaneous pregnancy. Currently, fertility restoration options are virtually nonexistent for this population. To become pregnant, the only solution is egg donation. Interestingly, animal studies have provided encouraging results in terms of fertility restoration, and consequently, research has begun into the most promising approaches for women suffering from POI. The PubMed database was searched for studies in which techniques aiming at restoring fertility in women with spontaneous POI were tested. Although robust studies are lacking, the literature suggests a positive effect of certain techniques on fertility restoration in women with POI. The most promising approaches seem to be intraovarian injection of autologous platelet-rich plasma or of mesenchymal stem cells. In addition to these, in vitro and mechanical activation of dormant follicles and etiology-driven therapies have also been studied with mixed results. No safety concerns were raised in these studies. The absence of robust studies does not allow us to draw meaningful conclusions on the efficacy or superiority of any single technique at this stage, and so research in this area should continue using robust study designs, i.e., multicenter randomized controlled trials including sufficient subjects to achieve statistical power.

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Section: Resultsmentioning

confidence: 99%

Restoration of Fertility in Patients with Spontaneous Premature Ovarian Insufficiency: New Techniques under the Microscope

Mawet¹,

d'HAUTERIVE

Henry³

et al. 2021

JCM

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“…Upon activation of PRP, numerous pockets of growth factors and cytokines release in the desired site and exert anabolic and anti-inflammatory actions by potentiating various cells and their secretomes as shown in Figure 3 [108]. PRP potentiated the differentiation of TSCs to mature tenocyte by increasing the proliferation and collagen production [109].…”

Section: Platelet-rich Plasma (Prp)mentioning

confidence: 99%

“…The administration of PRP accelerates and hastens neovascularization and stimulates the potentiation of the resident stem cells and the subsequent restoration of injured tissue. Upon activation of PRP, numerous pockets of growth factors and cytokines release in the desired site and exert anabolic and anti-inflammatory actions by potentiating various cells and their secretomes as shown in Figure 3 [ 108 ]. PRP potentiated the differentiation of TSCs to mature tenocyte by increasing the proliferation and collagen production [ 109 ].…”

Section: Orthobiologics In Atmentioning

confidence: 99%

Application of Orthobiologics in Achilles Tendinopathy: A Review

Ramires

Jeyaraman

Muthu

et al. 2022

Life

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Orthobiologics are biological materials that are intended for the regeneration of bone, cartilage, and soft tissues. In this review, we discuss the application of orthobiologics in Achilles tendinopathy, more specifically. We explain the concepts and definitions of each orthobiologic and the literature regarding its use in tendon disorders. The biological potential of these materials can be harnessed and administered into injured tissues, particularly in areas where standard healing is disrupted, a typical feature of Achilles tendinopathy. These products contain a wide variety of cell populations, cytokines, and growth factors, which have been shown to modulate many other cells at local and distal sites in the body. Collectively, they can shift the state of escalated inflammation and degeneration to reestablish tissue homeostasis. The typical features of Achilles tendinopathy are failed healing responses, persistent inflammation, and predominant catabolic reactions. Therefore, the application of orthobiologic tools represents a viable solution, considering their demonstrated efficacy, safety, and relatively easy manipulation. Perhaps a synergistic approach regarding the combination of these orthobiologics may promote more significant clinical outcomes rather than individual application. Although numerous optimistic results have been registered in the literature, additional studies and clinical trials are still highly desired to further illuminate the clinical utility and efficacy of these therapeutic strategies in the management of tendinopathies.

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“…The components of PRP enable the accelerated growth of various tissues with minimal side effects. The local release of growth factors and cytokines stimulates wound healing [118]. A recent systematic review revealed that PRP application can accelerate wound closure.…”

Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

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The regenerative mechanisms of platelet-rich plasma: A review

Cited by 66 publications

References 87 publications

Restoration of Fertility in Patients with Spontaneous Premature Ovarian Insufficiency: New Techniques under the Microscope

Restoration of Fertility in Patients with Spontaneous Premature Ovarian Insufficiency: New Techniques under the Microscope

Application of Orthobiologics in Achilles Tendinopathy: A Review

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

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