The regeneration of lenses in eyes with intact and regenerating retina in adult Triturus. v. viridescens

Stone, L. S.; Steinitz, H.

doi:10.1002/jez.1401240304

Cited by 76 publications

(9 citation statements)

References 23 publications

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“…Degeneration of retina (by loss of blood supply) resulted in inhibition of lens regeneration (Stone, 1966). Similarly, when the lens was regenerating together with the retina, lens regeneration was delayed and the final regenerated lenses were smaller and cataractous (Stone and Steinitz, 1953). Other cytochemical studies have shown that activity of alkaline phosphatase changes in the retina after lentectomy, reaching a peak at day 14 (Posalaky et al, 1951).…”

Section: Discussionmentioning

confidence: 94%

Regulation of Homeobox-containing Genes during Lens Regeneration

Jung

Rio‐Tsonis

Tsonis

1998

Experimental Eye Research

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Section: Discussionmentioning

confidence: 94%

Regulation of Homeobox-containing Genes during Lens Regeneration

Jung

Rio‐Tsonis

Tsonis

1998

Experimental Eye Research

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“…6C is that it is vacuolated. These vacuoles are signs of cataractous lens and have been observed mostly when lens regenerates concomitantly with retina in newt eyes where both the neural retina as well as the lens have been removed (26).…”

Section: Resultsmentioning

confidence: 99%

Conservation of fibroblast growth factor function in lens regeneration

Rio‐Tsonis

Jung

Chiu

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

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In urodele amphibians, lens induction during development and regeneration occurs through different pathways. During development, the lens is induced from the mutual interaction of the ectoderm and the optic vesicle, whereas after lentectomy the lens is regenerated through the transdifferentiation of the iris-pigmented epithelial cells. Given the known role of fibroblast growth factors (FGFs) during lens development, we examined whether or not the expression and the effects of exogenous FGF during urodele lens regeneration were conserved. In this paper, we describe expression of FGF-1 and its receptors, FGFR-2 (KGFR and bek variants) and FGFR-3, in newts during lens regeneration. Expression of these genes was readily observed in the dedifferentiating pigmented epithelial cells, and the levels of expression were high in the lens epithelium and the differentiating fibers and lower in the retina. These patterns of expression implied involvement of FGFs in lens regeneration. To further elucidate this function, we examined the effects of exogenous FGF-1 and FGF-4 during lens regeneration. FGF-1 or FGF-4 treatment in lentectomized eyes resulted in the induction of abnormalities reminiscent to the ones induced during lens development in transgenic mice. Effects included transformation of epithelial cells to fiber cells, double lens regeneration, and lenses with abnormal polarity. These results establish that FGF molecules are key factors in fiber differentiation, polarity, and morphogenesis of the lens during regeneration even though the regenerating lens is induced by a different mechanism than in lens development. In this sense, FGF function in lens regeneration and development should be regarded as conserved. Such conservation should help elucidate the mechanisms of lens regeneration in urodeles and its absence in higher vertebrates.

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“…In the lens of adult rabbits, rats, monkeys, and of Morphologically, no significant difference in the rate of lens regeneration is considcrcd between T. pyrrhoguster (SATO 1940) and l'. viridescens (STONE and STEINITZ 1953). calves, WANKO and GAVIN ( 1959) found that mitochondria1 profiles show some clear differences among stages of lens fibers.…”

Section: Cytodiferentintion and Ocular Environmentmentioning

confidence: 97%

“…Histological investigations (STONE andSTEINITZ 1953, for review see REYER 1954) show that mitotic figures are found at the late stage of the depigmentation. The same is reported by YAMADA and KARASAKI (1963).…”

Section: In T (Diemyctylus) Uiridescensmentioning

confidence: 99%

Electron Microscopic Studies on Lens Regeneration

Eguchi

1964

Embryologia

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The regeneration of lenses in eyes with intact and regenerating retina in adult Triturus. v. viridescens

Cited by 76 publications

References 23 publications

Regulation of Homeobox-containing Genes during Lens Regeneration

Regulation of Homeobox-containing Genes during Lens Regeneration

Conservation of fibroblast growth factor function in lens regeneration

Electron Microscopic Studies on Lens Regeneration

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