The reference method influence on the sensitivity of the Clostridium difficile enzyme immunoassays: A meta analysis

Martins, João Paulo; Felgueiras, Miguel; Santos, Rui

doi:10.1016/j.mimet.2020.105912

Cited by 1 publication

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“…Despite its low sensitivity (58.8 %), EIA presents high specificity (reaching almost 100%), and it is a common procedure used for the detection of C. difficile. Moreover, the optimal approach for the detection of C. difficile infection is still a matter of debate [38,39].…”

Section: Discussionmentioning

confidence: 99%

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Implication of COVID-19 pandemic on the incidence of Clostridioides difficile infection in a Greek tertiary hospital

Κarampatakis

Tsergouli

Kandilioti

et al. 2023

Journal of Medical Microbiology

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Introduction. C. difficile infection (CDI) represents an important global threat. In the COVID-19 era, the multifactorial nature of CDI has emerged. Hypothesis – Aim. The aim was to assess the impact of COVID-19 pandemic on the incidence of CDI in a Greek hospital. Methodology. A retrospective study was performed throughout a 51 month period (January 2018 to March 2022), divided into two periods: pre-pandemic (January 2018 to February 2020) and COVID-19 pandemic (March 2020 to March 2022). The effects of the pandemic compared to the pre-pandemic period on the incidence of CDI [expressed as infections per 10 000 bed days (IBD)] were studied using interrupted time-series analysis. Results. Throughout the study, there was an increase in the monthly CDI incidence from 0.00 to 11.77 IBD (P<0.001). Interrupted time-series disclosed an increase in CDI incidence during the pre-pandemic period from 0.00 to 3.36 IBD (P<0.001). During the COVID-19 pandemic period the linear trend for monthly CDI rose from 2.65 to 13.93 IBD (P<0.001). The increase rate was higher during the COVID-19 pandemic period (r2 = +0.47) compared to the pre-pandemic period (r1 = +0.16). Conclusion. A significant increase of CDI incidence was observed, with the rate of the rise being more intense during the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, the optimal approach for the detection of C. difficile infection is still a matter of debate [38, 39].…”

Section: Discussionmentioning

confidence: 99%

Implication of COVID-19 pandemic on the incidence of Clostridioides difficile infection in a Greek tertiary hospital

Κarampatakis

Tsergouli

Kandilioti

et al. 2023

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

The reference method influence on the sensitivity of the Clostridium difficile enzyme immunoassays: A meta analysis

Cited by 1 publication

References 75 publications

Implication of COVID-19 pandemic on the incidence of Clostridioides difficile infection in a Greek tertiary hospital

Implication of COVID-19 pandemic on the incidence of Clostridioides difficile infection in a Greek tertiary hospital

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