The Reference Intervals of Whole Blood Copper, Zinc, Calcium, Magnesium, and Iron in Infants Under 1 Year Old

Ha, Feizai; Wu, Yonghua; Wang, Haining; Wang, Tiancheng

doi:10.1007/s12011-021-02620-6

Cited by 7 publications

(1 citation statement)

References 43 publications

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“…A large study by Ha et al 31 reported gender and age specific paediatric reference intervals for whole blood trace element levels in infants under 1 year. Samples were collected from 13 446 infants attending routine outpatient assessments between 2007 and 2019 (7206 boys, 6240 girls).…”

Section: Metrology Interlaboratory Studies Reference Materials and Re...mentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca

Barlow

Cross³

et al. 2022

J. Anal. At. Spectrom.

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Section: Metrology Interlaboratory Studies Reference Materials and Re...mentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca

Barlow

Cross³

et al. 2022

J. Anal. At. Spectrom.

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Data Mining in Establishing the Indirect Reference Intervals of Biochemical and Haematological Assays in the Paediatric Population: A Review

Nasuruddin,

Salwana,

Sarker

et al. 2023

Lecture Notes in Computer Science

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Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

Feng

Yang

Zhao

et al. 2022

npj Biofilms Microbiomes

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Exposure to heavy metals (HMs) is a threat to human health. Although probiotics can detoxify HMs in animals, their effectiveness and mechanism of action in humans have not been studied well. Therefore, we conducted this randomized, double-blind, controlled trial on 152 occupational workers from the metal industry, an at-risk human population, to explore the effectiveness of probiotic yogurt in reducing HM levels. Participants were randomly assigned to two groups: one consumed probiotic yogurt containing the HM-resistant strain Pediococcus acidilactici GR-1 and the other consumed conventional yogurt for 12 weeks. Analysis of metal contents in the blood revealed that the consumption of probiotic yogurt resulted in a higher and faster decrease in copper (34.45%) and nickel (38.34%) levels in the blood than the consumption of conventional yogurt (16.41% and 27.57%, respectively). Metagenomic and metabolomic studies identified a close correlation between gut microbiota (GM) and host metabolism. Significantly enriched members of Blautia and Bifidobacterium correlated positively with the antioxidant capacities of GM and host. Further murine experiments confirmed the essential role of GM and protective effect of GR-1 on the antioxidative role of the intestine against copper. Thus, the use of probiotic yogurt may be an effective and affordable approach for combating toxic metal exposure through the protection of indigenous GM in humans.ClinicalTrials.gov identifier: ChiCTR2100053222

show abstract

The Reference Intervals of Whole Blood Copper, Zinc, Calcium, Magnesium, and Iron in Infants Under 1 Year Old

Cited by 7 publications

References 43 publications

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Data Mining in Establishing the Indirect Reference Intervals of Biochemical and Haematological Assays in the Paediatric Population: A Review

Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

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